Prevention of Frey Syndrome During Parotidectomy

Dulguerov, Pavel; Quinodoz, Didier; Cosendai, Gregoire; Piletta, Pierre; Marchal, Francis; Lehmann, Willy

doi:10.1001/archotol.125.8.833

Cited by 120 publications

(115 citation statements)

References 25 publications

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“…1,11 So far, the available treatments have either been of temporary benefit or are associated with potential side effects that are more important than the symptoms to be treated. The treatment of Frey syndrome with botulinum toxin injection, following a suggestion of Drobik and Laskawi, 24 appears an attractive option.…”

Section: Discussionmentioning

confidence: 99%

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Frey syndrome treatment with botulinum toxin☆

Dulguerov¹,

QUINODOZ²,

COSENDAI³

et al. 2000

Otolaryngology - Head and Neck Surgery

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The goal of this work is to present our results of the intradermic infiltration with botulinum toxin in patients with Frey syndrome. Sixteen hemifaces in 15 patients were studied. Gustatory stimulation was evoked by sucking on a slice of lemon while measurements were done on both hemifaces, with the normal side being used as a control. Skin temperature and color (erythema) were measured with a digital surface thermometer and a skin chromameter, respectively. Sweat quantity and surface were measured by using the previously described blotting paper and iodine-sublimated paper histogram methods, respectively. Testing was repeated 2 weeks after skin infiltration with botulinum toxin (dilution of 50 U/mL). The interinjection distances were 1 cm, and 0.1 mL (5 U) was infiltrated at each injection site. Frey syndrome complaints disappeared in all patients. Small residual amounts of sweat were measurable. The difference in sweat quantity before and after botulinum toxin infiltration was significant in every patient (P < 0.001). Skin temperature and color measurement gave inconclusive results. In conclusion, Frey syndrome treatment with botulinum toxin is an efficient and welltolerated technique. Further work should address the optimal injection parameters.

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Section: Discussionmentioning

confidence: 99%

“…9,10 Once present, Frey syndrome continues unabated without treatment. 1,2 Although Frey syndrome is probably an unavoidable aftereffect of parotidectomy, 1,11 only about half of the patients are symptomatic. 1,11 Among symptomatic patients, about half judge their symptoms as "important or embarrassing."…”

mentioning

confidence: 99%

Frey syndrome treatment with botulinum toxin☆

Dulguerov¹,

QUINODOZ²,

COSENDAI³

et al. 2000

Otolaryngology - Head and Neck Surgery

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“…Techniques such as sternocleidomastoid (SCM) muscle flaps, superficial musculoaponeurotic system (SMAS) interposition, and artificial implants have been described with varying degrees of success. [4][5][6] This work is a metaanalysis of published studies of proposed methods for minimizing facial contour defects and Frey syndrome after superficial parotidectomy.…”

Section: Arch Facial Plast Surg 2009;11(5):327-331mentioning

confidence: 99%

“…Dulguerov et al 6 and others have reviewed their experience with various implants, including expanded polytetrafluoroethylene, polygalactin-910 mesh, lyophilized dura, and acellular human dermis. Wound complications may be more frequent with implants; for example, with acellular dermis (Alloderm; LifeCell Corp, Woodlands, Texas) local complications were reported in approximately 25%.…”

Section: Commentmentioning

confidence: 99%

Meta-analysis of Surgical Techniques for Preventing Parotidectomy Sequelae

Curry¹,

King²,

Reiter³

et al. 2009

Arch Facial Plast Surg

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“…8 Therapy using intradermic botulinum toxin type A is currently growing in importance. 6,8 If 9,11,[13][14][15] One is the preservation and raising of a superficial musculoaponeurotic system SMAS flap. [16][17][18][19][20][21][22] If carried out by a surgeon with experience, the surgical act will be extended slightly 16 16 …”

Section: Discussionmentioning

confidence: 99%