Prevention of Exudative Diathesis in Chicks by Factor 3 and Selenium

Schwarz, Klaus; Bieri, John G.; Briggs, George M.; Scott, M. L.

doi:10.3181/00379727-95-23308

Cited by 170 publications

(36 citation statements)

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“…Interference of any one recognizable stage during this complex and intricate phenomenon could disrupt the entire process as a whole. Four decades ago, selenium (Se) was recognized as an essential nutrient on the basis of its ability to serve interchangeably with vitamin E in the prevention of vascular or muscular signs in experimental animals [2]. The metabolic basis of this nutrient remained unclear, however, until it was discovered that the enzyme glutathione peroxidase contained selenium as an essential component at its catalytic site [3].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of Selenium on N-Nitrosodiethylamine and Phenobarbital-Promoted Rat Liver Carcinogenesis.

Thirunavukkarasu

Jagadeeswaran

Babu

et al. 2000

J. Clin. Biochem. Nutr.

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SummaryThe chemoprotective efficacy of selenium, a dietary micronutrient, against chemically-induced hepatocarcinogenesis in rats was investigated. Carcinogenesis was performed by a single intraperitoneal injection of N-nitrosodiethylamine (DEN, 200 mg/kg body weight) with phenobarbital (0.05%) as a promoter in rats. When selenium-supplemented (4 ppm) drinking water was provided ad libitum throughout the experimental period, before the initiation, or during the promotion period it was found to be effective in elevating hepatic glutathione peroxidase activity to a statistically significant level measured either in hyperplastic nodules or in the non-nodular surrounding tissue compared with the level of the carcinogen control. Selenium treatment also increased the activity of this enzyme in kidney, lung, and erythrocytes to a significant level compared with the tissue or cell levels of the carcinogen control rats. A decrease in the number and size of hyperplastic nodules was observed in the selenium-treated groups. Hence, a direct correlation may be made between the hepatic selenium content with the formation of hyperplastic nodules and non-nodular surrounding liver tissues. Our results further confirm the fact that selenium is particularly protective in limiting the action of DEN during the initiation phase of hepatocarcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of Selenium on N-Nitrosodiethylamine and Phenobarbital-Promoted Rat Liver Carcinogenesis.

Thirunavukkarasu

Jagadeeswaran

Babu

et al. 2000

J. Clin. Biochem. Nutr.

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“…3 Numerous reports were published during the 1930s and 1940s as a result of these investigations. However, after the essential nature of Se was demonstrated, 11 the focus of most research efforts shifted to Se deficiency. Extensive mortality and teratogenesis among wild waterfowl at the Kesterson Wildlife Refuge in California recently rekindled interest in Se toxicity, especially in the popular press.…”

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confidence: 99%

Naturally Occurring Selenosis in Wyoming

et al. 1993

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Abstract.A review of Wyoming State Veterinary Laboratory records for 1947-1987 revealed no substantiated cases of naturally occurring selenosis. However, older reports attributed thousands of animal deaths to selenium each year in this area. Beginning in August 1988, cases of suspected selenosis and selenium deficiency were solicited from veterinarians and producers by announcements in various statewide livestock publications. As of August 1991, 4 cases (all horses) of naturally occurring selenosis have been confirmed. Clinical signs were most often referable to epithelial damage, e.g., hoof lesions and loss of mane and tail. None involved neurologic signs. Sources of selenium included native range and grass hay.

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“…The Patterson and Schwartz groups published the results in the same issue of the Proceedings of the Society for Experimental Biology and Medicine in September of 1957 (25,26). The data from my experiment with the Schwartz material are included in the Schwartz paper.…”

Section: Animal Nutrition Yearsmentioning

confidence: 79%

An Unexpected Life in Nutrition

Nesheim

2012

Annu. Rev. Nutr.

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In this biographical article, I describe the evolution of my career in nutrition from an early period as an animal nutritionist interested in amino acid metabolism and genetic variation in nutrient requirements to an involvement in human nutrition and international public health. The career changes were in some respects a mirror of the evolution of nutritional science in my lifetime. I spent my entire career at Cornell University in what I think of as three distinct phases. As a researcher and teacher in the Poultry Science Department, I was able to do research in animal nutrition and witness the rapid industrialization of the production of poultry meat and eggs, helped by the findings of the era of nutrient discovery in nutritional science. Later I had the opportunity to lead the reorganization of human nutrition at Cornell during a period when research in nutritional science turned away from identifying new nutrients and became increasingly concerned with the roles of diet and chronic disease. During this period my research focus evolved as I became interested in aspects of international nutrition problems, particularly the influence of parasitic infections on child health and nutrition.

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Prevention of Exudative Diathesis in Chicks by Factor 3 and Selenium

Cited by 170 publications

References 0 publications

Inhibitory Effect of Selenium on N-Nitrosodiethylamine and Phenobarbital-Promoted Rat Liver Carcinogenesis.

Inhibitory Effect of Selenium on N-Nitrosodiethylamine and Phenobarbital-Promoted Rat Liver Carcinogenesis.

Naturally Occurring Selenosis in Wyoming

An Unexpected Life in Nutrition

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