Prevention of Experimental Peritoneal Adhesions by Dextran

Choate, William H.; Just-Viera, Jorge O.; Yeager, George H.

doi:10.1001/archsurg.1964.01310200087019

Cited by 31 publications

(8 citation statements)

References 2 publications

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“…In the present study a promising effect of dextran was noted in minimizing the for mation of adhesions. In previous experimen tal models it also has been found that dextran significantly prevents adhesions following in testinal anastomosis or abrasions of the intes tinal serosa [3,11,12,19].…”

Section: Discussionmentioning

confidence: 95%

“…The fibrin net formed in the presence of dextran is coarse. This effect can be reversed by administration of factor VIII concentrate, and, therefore, may be caused by interference of dextran with factor VIII [1], Furthermore, dextran may act by reducing the contact be tween inflamed tissue surfaces, either by a 'sil iconizing' effect of the molecules [3,14], or by inducing a colloid osmotic mobilization of fluid into the peritoneal cavity [7].…”

Section: Discussionmentioning

confidence: 99%

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Use of Dextran to Prevent Intraperitoneal Adhesions Caused by Maize Starch Powder

Reikerås¹,

Nordstrand²

1985

Eur Surg Res

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Use of Dextran to Prevent Intraperitoneal Adhesions Caused by Maize Starch Powder

Reikerås¹,

Nordstrand²

1985

Eur Surg Res

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“…Dextran alters the fibrin structure making it more susceptible to plasmin digestion [17,25]. Dextran has also been reported to act as a lubricant [7], partly by inducing a colloid osmotic mobilization of fluid into the abdominal cavity [10]. It is probable that SAG acts along similar mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Semisoluble aminated glucan: Long-term efficacy against an intraperitonealE. coli challenge and its effect on formation of abdominal adhesions

Seljelid

1987

Res. Exp. Med.

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The first part of this study in the rat was designed to assess the immediate and, in particular, the long-term effects of semisoluble aminated glucan (SAG) with regard to an intraperitoneal (i.p.) E. coli challenge and side-effects. The severity of the E. coli peritonitis was evaluated by quantification of the concomitant bacteremia. The animals randomly received either 10 ml normal saline i.p. (controls) or 10 ml (50 mg) SAG i.p. (experimental groups). It was found that SAG had no immediate protective effect against the infectious challenge as no difference was detected in the bacterial clearance between saline- and SAG-treated rats at day 0. However, 2 days after injection of saline/SAG a substantial protection of SAG was noted as no blood-borne bacteria could be detected at 1, 2, 3, 4 and 5 h after the E. coli challenge in SAG-treated animals, whereas by contrast matching blood cultures were positive in all controls. A likewise protective effect against E. coli bacteremia of a single i.p. injection of SAG was demonstrated at 7, 21, and 49 days after the administration of the compound. During the 7-week experimental period no clinical side-effects of SAG were observed. At autopsy (days 0, 2, 7, 21, and 49, respectively) no gross pathologic conditions were found. Lung, spleen, and kidney sections from SAG-treated rats were normal, whereas tiny granulomas were exhibited in liver sections, possibly related to the hyperfunctional macrophage state which SAG induced. The second main object of the study was to evaluate SAG's effect on adhesion formation.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…In the event, dextran prophylaxis was without effect, and it could be concluded that in our experiments the stimulation to fibrin formation was too strong to be overcome by unstimulated fibrinolytic activity. Using more aggres sive methods for adhesion formation, some authors have observed an ef fect of dextran prophylaxis [4,7,12],…”

Section: Discussionmentioning

confidence: 99%

Effect of Dextran and Hyaluronic Acid on the Development of Postoperative Peritoneal Adhesions in Experimental Animals

Bergqvist¹,

Arfors²

1977

Eur Surg Res

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The development of postoperative peritoneal adhesions was studied in rats and rabbits, the frequency of adhesions in the experimental model used being very high. In the development of an adhesion, fibrin seems to be an important contributor to the bridge between different tissues. Dextran, which modifies the fibrin network and makes it more susceptible to lysis, was used as a possible prophylactic agent, but we found no difference between treated and control groups. It is concluded that the stimulus for fibrin formation in the peritoneal adhesions using this atraumatic model was too strong to be overcome by the normal fibrinolytic system. The anti-inflammatory reaction of hyaluronic acid did not diminish the frequency or degree of adhesions.

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Prevention of Experimental Peritoneal Adhesions by Dextran

Cited by 31 publications

References 2 publications

Use of Dextran to Prevent Intraperitoneal Adhesions Caused by Maize Starch Powder

Use of Dextran to Prevent Intraperitoneal Adhesions Caused by Maize Starch Powder

Semisoluble aminated glucan: Long-term efficacy against an intraperitonealE. coli challenge and its effect on formation of abdominal adhesions

Effect of Dextran and Hyaluronic Acid on the Development of Postoperative Peritoneal Adhesions in Experimental Animals

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