Prevention of experimental oral cancer by extracts of Spirulina‐Dunaliella algae

Abstract

An extract of Spirulina-Dunaliella algae was shown to prevent tumor development in hamster buccal pouch when a 0.1% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in mineral oil was applied topically three times weekly for 28 weeks. The algae extract was delivered by mouth in continued dosages of 140 micrograms in 0.4 ml mineral oil three times per week. After 28 weeks, the animals given vehicle and untreated controls all presented gross tumors of the right buccal pouch. Animals fed canthaxanthin presented a notably and statistically significant reduction in tumor number and size compared with controls. Animals fed beta-carotene demonstrated a smaller but statistically significant reduction in tumor number and size. The algae animals presented a complete absence of gross tumors. However, microscopic sections of the buccal pouch in the algae group showed localized areas of dysplasia and early carcinoma-in-situ undergoing destruction.

Influence de la température, de l'intensité lumineuse et du stade de croissance sur la composition biochimique deChlorella sorokinianaShihira & Krauss

“…A ce titre, les possibilités de valorisation de cette richesse naturelle apparaissent donc très importantes. De nombreux produits intéressant les industries chimiques, agroalimentaires, pharmaceutiques, cosmétiques et autres peuvent être extraits de bio-masses d'algues (Debro & Ward 1979, Leavitt 1983, Fattom & Shilo 1984, Moulton et al 1987, Borowitzka 1988a, Cannell et al 1988, Schwartz et al 1988, Gromov et al 1991. Par ailleurs, leur composition biochimique, particulièrement intéressante (teneur élevée en protéines, bonne composition en acides gras et acides aminés), en fait une source alimentaire de bonne qualité tant pour les animaux que pour les humains (Becker 1988).…”

Investigation on the Counteracting Effect of Spirulina Against Potentated Sulfonamide’s (Cotrim Ds®) Side Effects in Rat

“…It also improves immune function (Pugh et al, 2001), increases absorption of nutrients from foods and helps to protect against infection (Ozdemir et al, 2004). Spirulina reduces kidney toxicity caused by the heavy metal mercury and several pharmaceutical drugs (Mohan et al, 2006) also helps to fight against cancer (Schwartz et al, 1988) by promoting the release of tumor necrosis factor alpha, a chemical in the body that attacks tumor cells. It appears to increase production of anti-inflammatory chemicals known as interferons and interleukins (Lee and Werth, 2004).…”

Antilithiatic Influence of Spirulina on Ethylene Glycol-Induced Nephrolithiasis in Male Rats

“…The United Nations World Food Conference declared spirulina as "the best for tomorrow" and it is gaining popularity in recent years as a food supplement (Kapoor and Mehta, 1993). The spirulina ability as a potent anti-viral (Gustafson et al, 1989;Hayashi et al, 1993;Patterson et al, 1993;Hayashi et al, 1996;Shih et al, 2003), anti-cancer (Suda et al, 1986;Pang et al, 1988;Schwartz et al, 1988;Lisheng et al, 1991;Mathew et al, 1995;Ismail et al, 2009), hypocholesterolemic and hypolipidemic (Devi and Venkataraman, 1983;Becker et al, 1986;Nakaya et al, 1988;Iwate et al, 1990;Nagaoka et al, 2005;Colla et al, 2008), antidiabetic (Parikh et al, 2001;Muthuraman et al, 2009) and health improvement (Annapurna et al, 1991) agent is gaining attention as a nutraceutical and a source of potential pharmaceutical. Despite considerable progress in medical therapy, there is no satisfactory drug to treat kidney stones.…”