Prevention of exercise-induced asthma by a natural isomer mixture of β-carotene

Neuman, I; Nahum, Hermona; Ben‐Amotz, Ami

doi:10.1016/s1081-1206(10)63165-1

Cited by 58 publications

(35 citation statements)

References 39 publications

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“…Case selection was based on clinical criteria, including those with mild-to-moderate asthma, although no physiological measurements of asthma were obtained. No data on antioxidant supplements or other dietary antioxidants, such as carotenoids, were available, and these cannot be excluded as potential confounding factors, as they may modulate asthma activity [25,26].…”

Section: Discussionmentioning

confidence: 99%

Amino acids and asthma: a case-control study

Fogarty¹,

Broadfield²,

Lewis³

et al. 2004

Eur Respir J

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Amino acids contribute to various anti-oxidant and immunological activities relevant to asthma pathogenesis, raising the possibility that differences in amino acids may be involved in asthma aetiology. The authors hypothesised that cystine reduces the risk of asthma via glutathione metabolism. Methionine, glutamine, glutamic acid and glycine may have potential protective effects, whilst arginine, phenylalanine and tryptophan may have adverse effects in asthma.Fasting plasma levels of amino acids were compared in a case-control study. A total of 89 adults, aged 18-65 yrs, with asthma controlled by inhaled corticosteroids, were recruited from a volunteer database and local primary care registers, and compared with 89 controls individually matched for age, sex and primary care centre.Contrary to the primary hypothesis, cases had higher fasting plasma cystine levels than controls, and there was no difference between cases and controls in any of the other amino acids tested, with the exception of plasma glycine, which was associated with a strongly reduced risk of asthma (odds ratio for the highest tertile compared to lowest 0.30 (95% confidence interval (0.11-0.82)).This study negates the hypothesis that higher fasting plasma cystine levels have a protective effect on the risk of asthma, although the inverse correlation with plasma glycine deserves further investigation.

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Section: Discussionmentioning

confidence: 99%

Amino acids and asthma: a case-control study

Fogarty¹,

Broadfield²,

Lewis³

et al. 2004

Eur Respir J

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“…Two previous supplementation studies have used carotenoids to affect asthma outcomes. Oral administration of 30 mg/day lycopene [46] and 64 mg/day ␤-carotene [47] were both effective in reducing exercise induced bronchospasm in asthmatics. It is speculated that these results were due to the antioxidant actions of these carotenoids, however the mechanism was not investigated.…”

Section: Airway and Systemic Carotenoidsmentioning

confidence: 95%

Airway and Circulating Levels of Carotenoids in Asthma and Healthy Controls

Wood

Garg

Blake

et al. 2005

Journal of the American College of Nutrition

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“…Using either a dry powder of the b-carotene enriched alga Dunaliella bardawil (Neuman et al, 1999) or a tomato oleoresin product containing 6% lycopene, but with other carotenoids and phytochemicals (Neuman et al, 2000), all subjects receiving the carotenoid supplement showed a significant protection, as evaluated by measuring their post-exercise forced expiratory volume in 1 s (FEV 1 ). These authors conclude that they were observing an in vivo antioxidant action of the carotenoids, although they cannot exclude the possibility that the other components of these extracts were involved in their results (Neuman et al, 1999;Neuman et al, 2000).…”

Section: In Vivo Antioxidant Studiesmentioning

confidence: 99%