Prevention of encrustation and blockage of urinary catheters by Proteus mirabilis via pH-triggered release of bacteriophage

Milo, Scarlet; Hathaway, Hollie; Nzakizwanayo, Jonathan; Alves, Diana R.; Esteban, Patricia Perez; Jones, Brian V.; Jenkins, A. Toby A.

doi:10.1039/c7tb01302g

Cited by 54 publications

(61 citation statements)

References 61 publications

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“…68 Moreover, Milo et al prepared an infection-responsive surface coating for urinary catheters, which releases a therapeutic dose of bacteriophage in response to elevated urinary pH and delay catheter blockage. 69 These coatings were stable both in the absence of infection, and in the presence of urease negative bacteria. Quantitative and visual analysis of crystalline biofilm reduction show that bacteriophage constitute a promising strategy for the prevention of catheter blockage (Fig.…”

Section: Bactericidal Coatingsmentioning

confidence: 95%

“…Recent studies reported a method by using bacteriophage cocktail to modify silicone catheter with broad bactericidal efficacy . Moreover, Milo et al prepared an infection‐responsive surface coating for urinary catheters, which releases a therapeutic dose of bacteriophage in response to elevated urinary pH and delay catheter blockage . These coatings were stable both in the absence of infection, and in the presence of urease negative bacteria.…”

Section: Antimicrobial Strategies For Urinary Cathetersmentioning

confidence: 99%

Section: Antimicrobial Strategies For Urinary Cathetersmentioning

confidence: 99%

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Antimicrobial strategies for urinary catheters

Zhu

Wang

et al. 2018

J Biomedical Materials Res

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Over 75% of hospital‐acquired or nosocomial urinary tract infections are initiated by urinary catheters, which are used during the treatment of 16% of hospitalized patients. Taking the United States as an example, the costs of catheter‐associated urinary tract infections (CAUTI) are in excess of $451 million dollars/year. The biofilm formation by pathogenic microbes that protects pathogens from host immune defense and antimicrobial agents is the leading cause for CAUTI. Thus, tremendous efforts have been devoted to antimicrobial coating for urinary catheters in the past few decades, and it has been demonstrated to be one of the most direct and efficient strategies to reduce infections. In this article, we briefly summarize the current methods for preparation of antimicrobial coatings based on different stages in the biofilm formation, highlight recent progress in the urinary catheter coating material design and selection, discuss approaches to improving their long‐term antimicrobial efficacy, biocompatibility, multidrug resistance and recurrent infections, and finally outline future requirements and prospects in antimicrobial coating material design. The scope of the works surveyed is confined to antimicrobial urinary catheters. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 445–467, 2019.

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Section: Bactericidal Coatingsmentioning

confidence: 95%

Section: Antimicrobial Strategies For Urinary Cathetersmentioning

confidence: 99%

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Antimicrobial strategies for urinary catheters

Zhu

Wang

et al. 2018

J Biomedical Materials Res

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“…In many clinical trials, hydrogel catheters are used as the control or the standard of care catheter presumably because that was the type of catheter the hospital was using at that time [27,28]. Hydrogel catheters have being impregnated with silver molecules, bacteriophages, liposomes containing antibiotics, among others [27,60,61,[68][69][70][71]. Furthermore, hydrogel silver-coated catheters have been commonly used in hospital settings [28] but like many of the coatings discussed in this review, evidence for their efficacy is uncertain.…”

Section: Exopolysaccharide-specific Glycoside Hydrolasementioning

confidence: 99%

“…It is estimated that phage predation reduces the global bacterial population by half every 48 h [135]. Bacteriophages are argued to be a good option for catheter coatings as: 1) they have potential as biofilm control agents because their specificities can be tailored to target certain pathogens; 2) they are self-replicating in the presence of their host cells and are eliminated by the body in the absence of host cells; 3) they can be used effectively against multidrug-resistant bacteria; and 4) multiple phages can be combined to broaden the effective range of the treatment [68,69,135]. Although, the full timeline of phage activity is still unknown, there is evidence that bacteriophages only delay bacterial biofilm formation [68].…”

Section: Bacteriophagesmentioning

confidence: 99%

Urinary Catheter Coating Modifications: The Race against Catheter-Associated Infections

Andersen

Flores-Mireles

2019

Coatings

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Urinary catheters are common medical devices, whose main function is to drain the bladder. Although they improve patients' quality of life, catheter placement predisposes the patient to develop a catheter-associated urinary tract infection (CAUTI). The catheter is used by pathogens as a platform for colonization and biofilm formation, leading to bacteriuria and increasing the risk of developing secondary bloodstream infections. In an effort to prevent microbial colonization, several catheter modifications have been made ranging from introduction of antimicrobial compounds to antifouling coatings. In this review, we discuss the effectiveness of different coatings in preventing catheter colonization in vitro and in vivo, the challenges in fighting CAUTIs, and novel approaches targeting host-catheter-microbe interactions.

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Phage engineering and phage‐assisted CRISPR‐Cas delivery to combat multidrug‐resistant pathogens

Khambhati

Bhattacharjee

Gohil

et al. 2022

Bioengineering & Transla Med

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Antibiotic resistance ranks among the top threats to humanity. Due to the frequent use of antibiotics, society is facing a high prevalence of multidrug resistant pathogens, which have managed to evolve mechanisms that help them evade the last line of therapeutics. An alternative to antibiotics could involve the use of bacteriophages (phages), which are the natural predators of bacterial cells. In earlier times, phages were implemented as therapeutic agents for a century but were mainly replaced with antibiotics, and considering the menace of antimicrobial resistance, it might again become of interest due to the increasing threat of antibiotic resistance among pathogens. The current understanding of phage biology and clustered regularly interspaced short palindromic repeats (CRISPR) assisted phage genome engineering techniques have facilitated to generate phage variants with unique therapeutic values. In this review, we briefly explain strategies to engineer bacteriophages. Next, we highlight the literature supporting CRISPR-Cas9-assisted phage engineering for effective and more specific targeting of bacterial pathogens. Lastly, we discuss techniques that either help to increase the fitness, specificity, or lytic ability of bacteriophages to control an infection.

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Prevention of encrustation and blockage of urinary catheters by Proteus mirabilis via pH-triggered release of bacteriophage

Abstract: The crystalline biofilms of Proteus mirabilis can seriously complicate the care of patients undergoing long-term indwelling urinary catheterisation.

Cited by 54 publications

References 61 publications

Antimicrobial strategies for urinary catheters

Antimicrobial strategies for urinary catheters

Urinary Catheter Coating Modifications: The Race against Catheter-Associated Infections

Phage engineering and phage‐assisted CRISPR‐Cas delivery to combat multidrug‐resistant pathogens

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