Prevention of early‐onset neonatal group B streptococcal disease with selective intrapartum chemoprophylaxis

Boyer, Kenneth M.; Gotoff, Samuel P.

doi:10.1016/0020-7292(87)90268-2

Cited by 85 publications

(129 citation statements)

References 0 publications

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…IPA has been shown to reduce the risk of EOS GBS disease in newborns [1,5]. On this basis, recommendations for IPA have progressively broadened over the past fifteen years [2][3][4].…”

Section: Discussionmentioning

confidence: 99%

“…Twenty-five years ago, Boyer and Gotoff [1] demonstrated that intra-partum antibiotic (IPA) treatment of mothers reduced the likelihood of early-onset sepsis (EOS) due to group B streptococci (GBS) in their newborn infants. These observations spurred two obvious questions-for whom should we administer IPA, and what would be the overall impact of our IPA administration strategy?…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Strep and the city: Unexpected persistence of early-onset GBS sepsis despite increased intra-partum antibiotic prophylaxis in an urban university hospital

Peev

Cadichon

Ranganathan

et al. 2006

International Congress Series

View full text Add to dashboard Cite

“…IPA has been shown to reduce the risk of EOS GBS disease in newborns [1,5]. On this basis, recommendations for IPA have progressively broadened over the past fifteen years [2][3][4].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Strep and the city: Unexpected persistence of early-onset GBS sepsis despite increased intra-partum antibiotic prophylaxis in an urban university hospital

Peev

Cadichon

Ranganathan

et al. 2006

International Congress Series

View full text Add to dashboard Cite

“…En 1986, Boyer et al rapportaient les premières séries mettant en évidence une corrélation positive entre antibioprophylaxie anti-SGB par ampicilline et la diminution de l'infection ou de la colonisation néonatale à SGB. Les mères relevant d'une antibioprophylaxie perpartum sont celles pour lesquelles il existe un facteur de risque d'infection néonatale (travail prématuré -ici, hors sujet -, rupture prolongée des membranes, fièvre maternelle per-partum) [16]. Notons que l'incidence des sepsis nénonataux était retrouvée à 4,5 % [16].…”

Section: Conséquences Foetalesunclassified

“…Les mères relevant d'une antibioprophylaxie perpartum sont celles pour lesquelles il existe un facteur de risque d'infection néonatale (travail prématuré -ici, hors sujet -, rupture prolongée des membranes, fièvre maternelle per-partum) [16]. Notons que l'incidence des sepsis nénonataux était retrouvée à 4,5 % [16]. En fait, la préva-lence des sepsis à SGB oscillait entre 0,76 La valeur prédictive positive du test de dépistage du SGB est de 91 % et la valeur prédictive négative de 89 % lorsqu'il est réalisé à 36 SA.…”

Section: Conséquences Foetalesunclassified

Antibiotiques en fin de grossesse. À propos de cinq réactions allergiques sévères

Sentilhes¹,

Hamou²,

Renoult-Litzler³

et al. 2007

Gynécologie Obstétrique & Fertilité

View full text Add to dashboard Cite

“…1 " 3 Several strategies based on maternal antenatal cultures have been proposed for the prevention of early-onset GBS infection, as most cases of neonatal sepsis occur by vertical transmission from the mother. 4 " 7 However, the majority of colonized women do not give birth to infected neonates and antenatal cultures do not necessarily predict which women will be colonized intrapartum. 8 " 10 Therefore, prevention strategies based solely on maternal colonization continue to be problematic.…”

mentioning

confidence: 99%

Intrapartum Chemoprophylaxis for Group B Streptococcus Infection to Prevent Neonatal Disease: Who Should be Treated?

Philipson¹,

Herson²

1996

Amer J Perinatol

View full text Add to dashboard Cite

The purpose of this study was to examine the maternal risk factors associated with early onset Group B streptococcus (GBS) sepsis and determine the potential impact of intrapartum chemoprophylaxis using these risk factors. Using a computerized perinatal database, 26,525 deliveries over a five-year period (1989 to 1994) were identified. Neonates with GBS-positive cultures were identified and the neonatal and maternal chart of each case was reviewed. Twenty-six neonates (1 of 1000) had GBS sepsis documented by blood or cerebrospinal fluid culture. Maternal risk factor(s) were identified in 13 (50%) cases: preterm labor (5), preterm premature rupture of the membranes (5), prolonged rupture of membranes (6), sibling affected by symptomatic GBS infection (2), or maternal fever during labor (5). There were four mothers whose neonates had GBS sepsis in spite of intrapartum antibiotics. Intrapartum chemoprophylaxis for GBS based on risk factors alone will identify only half of the neonates who develop disease. Extension of intrapartum chemoprophylaxis to patients with risk factors appears to be necessary to prevent early onset disease in the other half. Since 85.7% of our total obstetrical population has no risk factors, this policy would require treating 1749 women to prevent one case of GBS sepsis. Chemoprophylaxis could be more appropriately targeted if mothers colonized with GBS could be identified in early labor.

show abstract

Prevention of early‐onset neonatal group B streptococcal disease with selective intrapartum chemoprophylaxis

Cited by 85 publications

References 0 publications

Strep and the city: Unexpected persistence of early-onset GBS sepsis despite increased intra-partum antibiotic prophylaxis in an urban university hospital

Strep and the city: Unexpected persistence of early-onset GBS sepsis despite increased intra-partum antibiotic prophylaxis in an urban university hospital

Antibiotiques en fin de grossesse. À propos de cinq réactions allergiques sévères

Intrapartum Chemoprophylaxis for Group B Streptococcus Infection to Prevent Neonatal Disease: Who Should be Treated?

Contact Info

Product

Resources

About