Prevention of deep vein thrombosis after hip replacement: randomised comparison between unfractionated heparin and low molecular weight heparin.

Leyvraz, P. F.; Bachmann, Fédor; Hoek, J A; Büller, H. R.; Postel, Marloes G.; Samama, M; Vandenbroek, M D

doi:10.1136/bmj.303.6802.543

Cited by 235 publications

(94 citation statements)

References 36 publications

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“…These results are consistent with previous studies in international literature, in which platelet counts have been monitored in several large clinical trials that compared UFH with LMWH as antithrombotic prophylaxis after hip surgery or for the treatment of deep venous thrombosis [16]. The investigators found that HIT occurred in 2 out of 199 patients (1.0%) who received UFH after hip-replacement surgery, as compared with none of 198 patients who received LMWH; both patients with thrombocytopenia also had proximal deep venous thrombosis [17].…”

Section: Discussionsupporting

confidence: 83%

The Incidence of Heparin Induced Thrombocytopenia in Orthopedic Surgery Patients in Khartoum, Sudan

2017

IJCRR

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Aim: The aim of this study was to determine the incidence of low molecular weight heparin (LMWH) induced thrombocytopenia in patients undergoing orthopedic surgery in Khartoum Teaching Hospital. Heparin induced thrombocytopenia (HIT) is a complication of heparin therapy in which the platelet count falls by 50% or more of the baseline value, or falls to below 150×10 9 /L.Methodology: This is a prospective cross sectional study carried out in Khartoum Teaching Hospital, Department of Orthopedic Surgery in the period between April-July 2013.Results: Seventy three patients were included, forty nine (67.1%) were males and 24 (32.9%) were females. Most of the patients were between 40-59 years of age (50.7%). Sixty nine (94.52%) of the patients were not exposed to heparin before. All patients received LMWH as prophylaxis except 2 patients who received it for treatment. Fifty patients (68.49%) received LMWH in a dose of 3500 (IU) per day while 23 patients (31.51%) received it in a dose of 4500 IU. Fifty six of the patients received LMWH for 2 weeks, 15 patients for less than 2 weeks while 2 patients for more than 2 weeks. All patients had a baseline platelet count equal or more than 150×10 9 /L. On day 14, none of the patients had 50% reduction or more in the platelet count from the baseline or a platelet count of less than 150×10 9 /L. Conclusion:The study found that no patient treated with LMWH had significant HIT.

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Section: Discussionsupporting

confidence: 83%

The Incidence of Heparin Induced Thrombocytopenia in Orthopedic Surgery Patients in Khartoum, Sudan

2017

IJCRR

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“…Fifteen articles were eligible for analysis (Table 1) and were grouped into 3 categories, as follows: 2 RCTs measuring HIT as an outcome 3,11 ; 3 nonrandomized prospective studies with a comparison group (concurrent or sequential control group) and measuring HIT as an outcome 12-14 ; 10 RCTs not measuring HIT but appropriately monitoring thrombocytopenia as an outcome. [15][16][17][18][19][20][21][22][23][24] We performed 3 different analyses.…”

Section: Resultsmentioning

confidence: 99%

Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis

Martel

Lee

Wells

2005

Blood

768

443

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“…In our study the ratio of proximal to calf DVT in the placebo group was 1 : 1.6. By contrast, in European and North American studies the ratio was 1 : 4 in patients receiving LMWH prophylaxis [3,7].…”

Section: Discussionmentioning

confidence: 86%

“…From the 4th to the 10th days after operation the dosage was increased to 62 IU/kg per single subcutaneous injection. This regime is similar to that used by Leyvraz et al [7], and is the dose recommended by the manufacturer.…”

Section: Methodsmentioning

confidence: 86%

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A prospective randomized study on the use of nadroparin calcium in the prophylaxis of thromboembolism in Korean patients undergoing elective total hip replacement

Yoo

Kang

Kim

et al. 1998

International Orthopaedics

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Prevention of deep vein thrombosis after hip replacement: randomised comparison between unfractionated heparin and low molecular weight heparin.

Cited by 235 publications

References 36 publications

The Incidence of Heparin Induced Thrombocytopenia in Orthopedic Surgery Patients in Khartoum, Sudan

The Incidence of Heparin Induced Thrombocytopenia in Orthopedic Surgery Patients in Khartoum, Sudan

Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis

A prospective randomized study on the use of nadroparin calcium in the prophylaxis of thromboembolism in Korean patients undergoing elective total hip replacement

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