The primary aim of the present article was to review the effect and the clinical significance of abutment dis-and reconnection on the peri-implant marginal bone levels.Materials and methods: English articles published from 2009 to April 2019 were identified on the MED-LINE, Cochrane Library, and PubMed databases, according to the PRISMA guidelines. Comparative in vivo studies on humans were included.Results: A total of 4 studies with different levels of bias were included in this review. A significant heterogeneity of the reported data was observed, which limited the compar-ison of the findings. The only parameter that was homogenous throughout all 4 studies was the marginal bone level measurement.Conclusion: Within the limitations of the present review, it can be suggested that minimizing the number of abutment dis-and reconnections would be beneficial to ensure minimal disruption to the peri-implant tissue and marginal bone level. However, the clinical significance of the marginal bone level changes is still inconclusive.