Prevention of Cutaneous Damages Induced by Radiotherapy in Breast Cancer: An Institutional Experience

Ravo, Vincenzo; Calvanese, Maria Grazia; Franco, Rossella Di; Crisci, Vincenzina; Murino, Paola; Manzo, Roberto; Morra, Anna; Cammarota, Francesca; Muto, Paolo

doi:10.1177/030089161109700609

Cited by 13 publications

(6 citation statements)

References 17 publications

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“…published that topical sodium hyaluronate did not reduce the development of ≥grade 2.0 radiation dermatitis severity, whereas Ravo et al . published that patients using sodium hyaluronate did not develop dermatitis >grade 2.0 severity (32, 33). Clearly, identification of effective topical or systemic treatment for radiation dermatitis is still necessary.…”

Section: Discussionmentioning

confidence: 99%

Curcumin for Radiation Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Thirty Breast Cancer Patients

et al. 2013

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Radiation dermatitis occurs in approximately 95% of patients receiving radiotherapy (RT) for breast cancer. We conducted a randomized, double-blind, placebo-controlled clinical trial to assess the ability of curcumin to reduce radiation dermatitis severity in 30 breast cancer patients. Eligible patients were adult females with noninflammatory breast cancer or carcinoma in situ prescribed RT without concurrent chemotherapy. Randomized patients took 2.0 grams of curcumin or placebo orally three times per day (i.e., 6.0 grams daily) throughout their course of RT. Weekly assessments included Radiation Dermatitis Severity (RDS) score, presence of moist desquamation, redness measurement, McGill Pain Questionnaire-Short Form and Symptom Inventory questionnaire. The 30 evaluable patients were primarily white (90%) and had a mean age of 58.1 years. Standard pooled variances t test showed that curcumin reduced RDS at end of treatment compared to placebo (mean RDS =2.6 vs. 3.4; P =0.008). Fisher’s exact test revealed that fewer curcumin-treated patients had moist desquamation (28.6% vs. 87.5%; P =0.002). No significant differences were observed between arms for demographics, compliance, radiation skin dose, redness, pain or symptoms. In conclusion, oral curcumin, 6.0 g daily during radiotherapy, reduced the severity of radiation dermatitis in breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Curcumin for Radiation Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Thirty Breast Cancer Patients

et al. 2013

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“…In clinical studies, a topical formulation of V. vinifera A. s-I-M.t-O.dij (Ixoderm®) has shown protection against the destructive effects of radiotherapy on skin in patients with breast cancer. This study recommends hydration of the skin with a moisturizing agent such as grape as this could protect skin from the cutaneous damage caused by radiotherapy (Ravo et al, 2011). Some clinical effects of grape and its active constituents are summarized in Table 6.…”

Section: Clinical Studiesmentioning

confidence: 99%

Review of the Pharmacological Effects ofVitis vinifera(Grape) and its Bioactive Constituents: An Update

2016

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Vitis vinifera fruit (grape) contains various phenolic compounds, flavonoids and stilbenes. In recent years, active constituents found in the fruits, seeds, stems, skin and pomaces of grapes have been identified and some have been studied. In this review, we summarize the active constituents of different parts of V. vinifera and their pharmacological effects including skin protection, antioxidant, antibacterial, anticancer, antiinflammatory and antidiabetic activities, as well as hepatoprotective, cardioprotective and neuroprotective effects in experimental studies published after our 2009 review. Clinical and toxicity studies have also been examined. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Omega-3,6,9 (Quinovit ® ) M.t-O.dij (Ixoderm ® ) among those used, determined the best results to prevent cutaneous radio-induced damage. Moreover, from our results, neither taxanes and/or anthracyclines based chemotherapy nor hormonal therapy increase breast cutaneous toxicity induced by radiotherapy [23]. About the second subgroup correlating breast volume with the use of Ixor ® , the first relationship that we made regarded acute skin toxicity, PTV and Chemotherapy ( Table 4).…”

Section: Cream Anthracycline Taxane Hormonementioning

confidence: 68%

Prevention and Treatment of Radiation Induced Skin Damage in Breast Cancer

Franco¹,

Ravo²,

Falivene³

et al. 2014

JCDSA

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Introduction: Skin toxicity is a frequent side effect of radio and chemo-treatments in patients treated for breast cancer after conservative surgery. The aim of this paper is to report our experience in the management of skin toxicity evaluating radiotherapy planning and using preventive local aids. Materials and Methods: We have observed 300 patients undergoing radiotherapy. All received the prescription of a prophylactic moisturizing cream. Skin toxicity was valuated according to Acute Radiation Morbidity Scoring Criteria of the RTOG. Moreover, in a subgroup of 100 patients, we correlated the study of breast volume and features of treatment plans, with the addition of topic prophylactic treatment, using an oral therapy based on Resveratrol, Lycopene, Vitamin C and Anthocyanins (Ixor ® ). In another subgroup, 100 patients were subjected to corneometry assessing numerically skin hydration before, during and after radiotherapy. Results: In all patients, we related skin toxicity and the type of cream used. All patients completed the radiotherapy treatment, and G4 cutaneous toxicity was not observed in any of them. In patients treated with topic treatment and therapy based on Resveratrol, Lycopene, Vitamin C and Anthocyanins (Ixor ® ), the protective effect of (Ixor ® ) is more detected in patients with PTV (Planning Target Volume) <500 ml, when Dmax reaches values lower or equal to 107%, but not exceeding 110% of the prescribed dose, and in patients undergoing adjuvant chemotherapy with anthracyclines and taxanes. The values of corneometry allow us to evaluate the moisturizing effect for products used, and identify cases of skin toxicity in a first phase. Conclusions: Our study confirms the value of moisturizers in the prevention and resolution of radiotherapy-induced skin damage. An instrumental assessment of skin hydration with corneometry can help the radiation oncologist to use strategies that prevent the onset of toxicity of high degree.

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Prevention of Cutaneous Damages Induced by Radiotherapy in Breast Cancer: An Institutional Experience

Cited by 13 publications

References 17 publications

Curcumin for Radiation Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Thirty Breast Cancer Patients

Curcumin for Radiation Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Thirty Breast Cancer Patients

Review of the Pharmacological Effects ofVitis vinifera(Grape) and its Bioactive Constituents: An Update

Prevention and Treatment of Radiation Induced Skin Damage in Breast Cancer

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