Prevention of Corneal Ulceration in the Developing World

Crosslinked collagen–gelatin–hyaluronic acid biomimetic film for cornea tissue engineering applications

“…Corneal disease is a major cause of blindness worldwide. About 10 million people worldwide suffer from vision loss probably caused by corneal disease [2]. Corneal transplantation has been one even the only one of the effective methods to treat some corneal diseases.…”

A Viral Model for Corneal Scarring and Neovascularization Following Ocular Infection of Rabbits With a Herpes Simplex Virus Type 1 (HSV-1) Mutant

“…[26][27][28] Corneal diseases producing corneal scarring are a common cause of monocular and bilateral blindness in children and young adults. 29,30 Angiogenesis is a central feature of many important diseases, including cancer, rheumatoid arthritis, atherosclerosis, and ocular neovascularization. 31 Although several animal models have been used to investigate HSV-1 keratitis 32,33 and angiogenesis resulting in eye disease, 34-37 the current systems do not faithfully model the clinical corneal diseases.…”

Antibiotics which Target the Wolbachia Endosymbionts of Filarial Parasites: A New Strategy for Control of Filariasis and Amelioration of Pathology

“…Host inflammatory reactions to dead O. volvulus larvae (microfilariae, MF) in the skin and eyes causes skin disease, Sowda or leopard skin, and visual impairment. In Africa, 500,000 cases of visual impairment, of which 270,000 cases resulted in blindness, are the direct result of O. volvulus, making onchocerciasis the second most frequent cause of preventable blindness in sub-Saharan Africa [3,4]. It should be noted that the cases of blindness reported here do not reflect the success of the vector control programme for onchocerciasis which concluded in 2002.…”