Prevention of colorectal cancer by once-only sigmoidoscopy

Atkin, Wendy; Northover, John; Cuzick, Jack; Whynes, David K.

doi:10.1016/0140-6736(93)90499-7

Cited by 326 publications

(158 citation statements)

References 25 publications

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“…1 However, the majority of these deaths are preventable through routine screening, beginning at 50 years of age, as outlined and recommended in clinical practice guidelines. [2][3][4][5][6][7][8] Although screening has been found to be cost effective, screening rates are generally low for the entire US population, with only about half of adults 50 years of age or older being screened according to guidelines in 2004. 9 In comparison with non-Hispanic whites in the United States, African Americans suffer disproportionately higher incidence (62.3 vs 52.6 per 100,000) and far are limited in number and have primarily used focus group methodology consisting of study populations not adherent to screening guidelines.…”

Section: Introductionmentioning

confidence: 99%

Colorectal Cancer Screening and African Americans: Findings from a Qualitative Study

2008

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Section: Introductionmentioning

confidence: 99%

Colorectal Cancer Screening and African Americans: Findings from a Qualitative Study

2008

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“…flexible sigmoidoscopy for persons older than 50 years), the protocol followed ultimately depends on the specific communityof physicians (33). While a screening method using sigmoidoscopy can prevent deaths by colorectal cancer (34)(35)(36), up to 40%of colorectal neoplasms maygo undetected (37). Further consensus amongphysicians maybe obtained if rather than sigmoidoscopy, weadopted another strategy in which patients whohave tested positive on the Immunohemostick test are then subjected to a total colonoscopy.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of Detection of Colorectal Neoplasia Using an Immnochemical Occult Blood Test in Symptomatic Referred Patients. Comparison of Retrospective and Prospective Studies.

et al. 2000

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Objective In this study the sensitivity and specificity of immunochemical tests for colorectal neoplasia were evaluated in retrospective and prospective studies. Methods Four types of fecal blood tests -a chemical test (Hemoccult II) and three different immunochemical tests including a test which detects hemoglobin and transferrin-were performedin the retrospective study. In the prospective study the test for hemoglobin and transferrin was used for all patients that underwent total colonoscopy. Patients One hundred seven patients with colorectal neoplasia, 57 with gastroduodenal bleeding, and 62 with normal digestive tracts were examinedretrospectively. One thousand two hundred and ninety-eight nonspecifically symptomatic patients whose endoscopic examination was negative for hemorrhagic lesions in the upper digestive tract were examined prospectively.Results In the retrospective study, sensitivities for the detection of colorectal cancers and adenomaswith diameters^10 mmusing the tests which detect hemoglobin and transferrin were 98%and 89%, respectively. These were the highest sensitivity among the four tests. The specificity of this test was 97%, which was higher than that of the Hemoccult II test. In the prospective study, the sensitivities of the tests for hemoglobin and transferrin for the detection of colorectal cancers and adenomaswith diameters^10 mmwere 79%and 33%, respectively. The specificity was 95%.Conclusions The test for hemoglobin and transferrin showed the highest sensitivity and specificity for colorectal neoplasia in the retrospective study. The sensitivity and specificity of this test were not so high in the prospective study, but they may be clinically applicable in the evaluation of patients with various nonspecific symptoms. (Internal Medicine 39: 701-706, 2000)

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“…The rationale behind using FS as a screening Review tool in CRC hinges on observations that distal CRC are more common than proximal CRC; sigmoidoscopy and polypectomy prevent the development of distal CRC; and proximal colonic lesions are frequently associated with advanced distal disease [56][57][58]. Its usage is usually in a two-stage model, with FS used in conjunction with colonoscopy for initial FS-positive patients.…”

Section: Flexible Sigmoidoscopymentioning

confidence: 99%