Prevention of chronic rejection by pravastatin in a rat kidney transplant model.

Abstract

This study demonstrates the ability of pravastatin to inhibit chronic rejection in rat renal allografts. Pravastatin's pleiotropic effects of reducing intragraft inflammatory cytokines, inhibiting immune cell infiltration, and causing up-regulation of the antiapoptotic gene Bag-1 suggest that its ability to prevent transplant chronic rejection may be multifactorial.

Ezetimibe in Renal Transplant Patients with Hyperlipidemia Resistant to HMG-CoA Reductase Inhibitors

“…Anti-inflammatory effects may be greater with statin therapy as demonstrated in a recent comparison of C-reactive protein reductions versus eztimibe (20). Lastly, statins may reduce chronic allograft nephropathy (21) and due to mild immunosuppression provided by statin agents, acute rejection rates maybe lowered (22). No adverse events were reported by the patients nor discerned on laboratory measurements (liver functions, serum creatinine).…”

Combined Effects of Losartan and Pravastatin on Interstitial Inflammation and Fibrosis in Chronic Cyclosporine-Induced Nephropathy

“…Moreover, the functions of statins also extend to immunomodulation, as shown by their inhibition of the expression of class II major histocompatibility antigens and of natural killer cell activity (44). Indeed, experimental and clinical studies in cardiac and renal-transplant recipients demonstrate that administration of statins successfully decreases acute or chronic rejection episodes and improves graft survival (45)(46)(47). Thus, combined treatment of LSRT plus PRVT may provide additional renoprotection not only for chronic CsA-induced nephropathy but also for rejection episodes in transplant recipients receiving CsA.…”

Pioglitazone limits cyclosporine nephrotoxicity in rats

“…These actions lead to tubule-interstitial fibrosis and arteriolopathy [5][6][7]. It has been demonstrated by several groups in different experimental models that blocking some pathways of this cascade can actually limit CsA nephrotoxicity [8][9][10][11][12].…”