“…Despite this clear-cut efficacy, clinical testing of this potent agent has expanded only slowly because of dose-related hepatotoxicity observed in the rabbit (Fischer et al, 1974), rhesus monkey (Webster et al, 1975;Dyrszka et al, 1976), and baboon (Morrissey et al, 1975). There is now strong evidence implicating lithocholic acid, the principal bacterial metabolite of chenic acid, as the major factor in chenic acid induced liver injury (Palmer, 1972;Fischer et al, 1974;Morrissey et al, 1975;Salen et al, 1975;Webster et al, 1975;Dyrszka et al, 1976;Gadacz et al, 1976).…”