Prevention of Cerebrospinal Fistulae and Reduction of Epidural Scar with New Surgical Hemostat Device in a Porcine Laminectomy Model

Abstract

CoStasis and Tissucol have comparable effectiveness in sealing CSF leaks immediately and at 3 weeks after complete laminectomy. CoStasis demonstrated comparable performance to Tissucol with less epidural scar formation than primary suture alone.

Reduction in postlaminectomy epidural adhesions in sheep using a fibrin sealant‐based medicated adhesion barrier

“…34 This is further supported by the finding that Tissu-col TM (Tisseel TM ) fibrin sealant not only allowed for effective dural sealing but also reduced scar formation at the surgery site in a porcine laminectomy model. 35 Although these findings are encouraging, fibrin sealant alone is not sufficient to constitute an effective means of preventing long-term epidural adhesion formation and combination with other potential antiadhesive agents may be required.…”

An Interlaminotomy New Zealand White Rabbit Model to Evaluate Novel Epidural Strategies

“…canine, [17][18][19] porcine, 20,21 and murine models, 22,23 have been used to study the formation and prevention of epidural scar formation. The rabbit laminectomy model is an established surgical procedure 9,10 because it is both cost effective and saves time.…”

Análisis de las complicaciones de la cirugía de la hernia discal lumbar

“…Las complicaciones intraoperatorias descritas son: desgarro de la duramadre 6,8,17,42,49 lesión de estructuras retroperitoneales 5,19,21,24,25,27,33,37,39,40,45,46 y lesión de una raíz raquídea 10, 11,40 . Las complicaciones postoperatorias descritas, vinculadas directamente al procedimiento son: infecciones 3,4,7,11,14,26,28,29,30,36,39,41,43 , fístula de LCR 12,22 , pseudomeningocele 2,9,16,22,31,35,38,47 , hematoma epidural 11,13,32,34,44 , síndrome de Ogilvie 1,18,48 , y síndrome de cola de caballo postoperatorio 11,…”