Prevention of blindness in diabetic retinopathy

Kohner, Eva M.; Barry, Peter J.

doi:10.1007/bf00252402

Cited by 51 publications

(10 citation statements)

References 34 publications

(35 reference statements)

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“…27 The greater prevalence of diabetic retinopathy in patients on insulin than in those on diet and oral antidiabetic drugs may primarily reflect the difference in severity of metabolic abnormality (Table 4), but a detrimental role of insulin per se adding to the development of retinopathy cannot be excluded. 28 -29 Because both diabetic maculopathy and proliferative retinopathy can be treated effectively by photocoagulation, 30 it has to be appreciated that all type I diabetic patients had been sent for laser treatment. The same attitude still needs to be developed concerning treatment of proliferative diabetic retinopathy in type II diabetic patients, in whom photocoagulation has been withheld in >50%.…”

Section: Treatmentmentioning

confidence: 99%

Diabetes Care in Rural Area: Clinical and Metabolic Evaluation

Derfler

Waldhäusl

Zyman³

et al. 1986

Diabetes Care

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To evaluate the efficacy of conventional diabetes care in a rural area, metabolic control and the presence of late complications were studied in 622 diabetic patients treated by general practitioners beyond the reach of diabetic centers. Seventy-three (12%) of the patients were classified as type I diabetics (age, 38.0 +/- 16.1 yr; duration of diabetes, 12.8 +/- 9.3 yr) and 549 as type II diabetics (age, 67.0 +/- 10.8 yr; duration of diabetes, 7.3 +/- 5.8 yr). Fifty-eight percent of type I diabetic patients administered insulin once daily and 42% twice daily, whereas most (83%) type II diabetics on insulin received only one insulin injection per day. Treatment of type II diabetic patients consisted of sulfonylureas (58%), diet alone (22%), insulin (18%), and biguanides or a combination of sulfonylurea with biguanides (2%). Poor therapeutic efficacy was observed in all patients, and postprandial hyperglycemia (blood glucose greater than 160 mg/dl) was predominant both in type I diabetics (86%) and in type II diabetics on insulin (80%) as well as off insulin (55%). HbA1c above normal (greater than 5.8%) was seen in 96% of type I and in 90 and 73% of type II diabetics with or without insulin therapy, respectively. Accompanying glucosuria was present in type I (73%) and in type II diabetics (on insulin, 71%; off insulin, 33%). Mean prevalence of late diabetic complications was greatest for insulin-treated patients (type I, type II with, and type II without insulin treatment: retinopathy, 41, 56, 22%; proteinuria, 13, 14, 3%; peripheral neuropathy, 21, 51, 12%), whereas macroangiopathy (16, 53, 31%) predominated in type II diabetic patients.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Treatmentmentioning

confidence: 99%

Diabetes Care in Rural Area: Clinical and Metabolic Evaluation

Derfler

Waldhäusl

Zyman³

et al. 1986

Diabetes Care

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“…Screening for diabetic retinopathy prevents blindness and is cost effective 1 2 3 4 5. Because of the inadequacies of current screening programmes, however, many diabetic patients never receive treatment before developing severe visual loss 6.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity and specificity of photography and direct ophthalmoscopy in screening for sight threatening eye disease: the Liverpool diabetic eye study

Harding

Broadbent

Neoh

et al. 1995

BMJ

250

181

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“…Diabetic retinopathy is one of the most serious causes of visual impairment and blindness in Western countries [1,2]. Al though extensive studies on this late compli cation of diabetes have been performed, its pathogenesis is still obscure.…”

Section: Introductionmentioning

confidence: 99%

Studies on the Retina of the Diabetic db/db Mouse

et al. 1989

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The genetically diabetic db/db mouse is a model of type-2 diabetes, where nephropathy and neuropathy, but not retinopathy were observed. The authors studied the retinas (trypsin digestion technique) of 16 db/db mice and 16 age-matched litter mates (db/m; controls), divided into five age groups. They noted a marked increase in the ratio of endothelial cells to intramural pericytes in diabetic mice compared to controls. This increase resulted from a selective and highly significant loss of pericytes in db/db mice (p < 0.05). Some strand-like and relatively acellular capillaries were also observed. The db/db mouse may represent an adequate model for studies on the pathogenesis of retinopathy.

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Prevention of blindness in diabetic retinopathy

Cited by 51 publications

References 34 publications

Diabetes Care in Rural Area: Clinical and Metabolic Evaluation

Diabetes Care in Rural Area: Clinical and Metabolic Evaluation

Sensitivity and specificity of photography and direct ophthalmoscopy in screening for sight threatening eye disease: the Liverpool diabetic eye study

Studies on the Retina of the Diabetic db/db Mouse

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