Prevention of Biofilm-Induced Capsular Contracture With Antibiotic-Impregnated Mesh in a Porcine Model

Abstract

Based on the findings from this study of a porcine model, the use of antibiotic-impregnated mesh reduces bacterial access to breast implants at the time of surgical insertion and may subsequently protect against subclinical infection and CC.

The Role of Bacterial Biofilms in Device-Associated Infection

“…78 A recent animal study of breast implant contracture has shown that the concurrent use of antibiotic-impregnated absorbable mesh produced significantly less biofilm and contracture in a porcine model. 83 A similar mesh was also utilized in a clinical study of cardiovascular implantable electronic devices to produce a significantly lower infection rate at a 2-month follow-up. 84 Antibacterial coatings have been used on catheters and drains to reduce the risk of deviceassociated infection.…”

An Innovative Procedure for the Treatment of Primary and Recurrent Capsular Contracture (CC) Following Breast Augmentation

“…1,4,7,[11][12][13][14] Recent evidence suggests that subclinical infection and the presence of a bacterial biofilm on the surface of the implant could be a likely major contributor to CC. [15][16][17] Interestingly, a high bacterial colonization rate of 61% to 66.7% has been detected in association with grade III and IV contractures, suggesting that bacterial stimuli may accelerate the process of inflammation and fibrosis. 18 In addition to skin bacteria that might contact the breast implant during insertion, endogenous breast flora expressed through the nipple represent a potential source for colonization of the implant surface, producing a nidus for subclinical infection and biofilm formation.…”

Effects of Medical Chitosan on Capsular Formation Following Silicone Implant Insertion in a Rabbit Model

“…To further investigate capsular contracture, researchers have used various animal models, including rabbits, rats, pigs, and monkeys [35][36][37][38][39]. Rabbits are commonly used as their capsules have a close resemblance with those of humans [40].…”