Prevention of bacterial biofilm formation on orthodontic brackets by non-crosslinked chitosan coating

Wang, Yue; Xu, Jingchen; Chen, Yu; Zhou, Xueer; Chang, Liang; Li, Jun; Peng, Qiang

doi:10.1016/j.ijbiomac.2023.126283

Cited by 9 publications

(5 citation statements)

References 31 publications

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“…All samples were immersed in 75% ethanol for 30 min and then irradiated with UV light for another 30 min before the antibacterial test . The bacterial suspension was individually mixed with various scaffolds in a 48-well plate and cocultured at 37 °C for 24 h in an incubator . After processing, the bacterial solutions with scaffolds were subjected to irradiation with an NIR laser for 15 min.…”

Section: Methodsmentioning

confidence: 99%

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Photothermal and Photodynamic Synergistic Effect of the MXene/SnS₂ Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity

Shuai,

Long,

Sun

et al. 2024

ACS Appl. Polym. Mater.

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Bacterial infection is a severe challenge faced by artificial bone transplantation, which might cause delayed bone healing or even transplant failure. Photodynamic therapy (PDT) has garnered widespread attention as a treatment for infections due to its noninvasiveness, few side effects, and high spatiotemporal selectivity. Nevertheless, owing to the bacterial membrane obstacle, it is difficult for exogenous reactive oxygen species (ROS) to penetrate into bacteria, which leads to an unsatisfactory antibacterial effect. Herein, a heterojunction of Ti 2 C 3 nanosheets/tin disulfide (MXene/SnS 2 ) is designed, which integrates photothermal and photodynamic properties. Then, MXene/SnS 2 was incorporated into a poly-L-lactic acid powder (PLLA) matrix to fabricate an artificial bone scaffold with selective laser sintering (SLS) technology. Under near-infrared laser irradiation, SnS 2 can strengthen the near-infrared light absorption of MXene to generate local hyperthermia, thus enhancing bacterial membrane permeability. Meanwhile, MXene/SnS 2 enhances charge transfer and inhibits electron−hole pair separation, thereby generating more ROS that can penetrate the bacterial interior. The results indicated that this antibacterial strategy has effective antibacterial activity, and the antibacterial rate reached over 90%. Overall, this research presents an attractive antibacterial strategy for implant-related infection.

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Section: Methodsmentioning

confidence: 99%

“…27 The bacterial suspension was individually mixed with various scaffolds in a 48-well plate and cocultured at 37 °C for 24 h in an incubator. 28 After processing, the bacterial solutions with scaffolds were subjected to irradiation with an NIR laser for 15 min. A dark control group was maintained without irradiation.…”

Section: Physicochemical Characterizationsmentioning

confidence: 99%

Photothermal and Photodynamic Synergistic Effect of the MXene/SnS₂ Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity

Shuai,

Long,

Sun

et al. 2024

ACS Appl. Polym. Mater.

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“…The antibacterial activity of the FA-PC (molar ratio 1:1) against Gram-negative pathogens E. coli and P. aeruginosa was examined by CFU counting-based quantification as previously reported [34][35][36]. The FA-PC water solution was prepared the same as above.…”

Section: Antibacterial Activity Of Fa-pcmentioning

confidence: 99%

Reversing the Natural Drug Resistance of Gram-Negative Bacteria to Fusidic Acid via Forming Drug–Phospholipid Complex

Liu,

Lai,

et al. 2024

Bioengineering

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Drug resistance substantially compromises antibiotic therapy and poses a serious threat to public health. Fusidic acid (FA) is commonly used to treat staphylococcal infections, such as pneumonia, osteomyelitis and skin infections. However, Gram-negative bacteria have natural resistance to FA, which is almost restrained in cell membranes due to the strong interactions between FA and phospholipids. Herein, we aim to utilize the strong FA–phospholipid interaction to pre-form a complex of FA with the exogenous phospholipid. The FA, in the form of an FA–phospholipid complex (FA-PC), no longer interacts with the endogenous membrane phospholipids and thus can be delivered into bacteria cells successfully. We found that the water solubility of FA (5 µg/mL) was improved to 133 µg/mL by forming the FA-PC (molar ratio 1:1). Furthermore, upon incubation for 6 h, the FA-PC (20 µg/mL) caused a 99.9% viability loss of E. coli and 99.1% loss of P. aeruginosa, while free FA did not work. The morphology of the elongated bacteria cells after treatment with the FA-PC was demonstrated by SEM. The successful intracellular delivery was shown by confocal laser scanning microscopy in the form of coumarin 6-PC (C6-PC), where C6 served as a fluorescent probe. Interestingly, the antibacterial effect of the FA-PC was significantly compromised by adding extra phospholipid in the medium, indicating that there may be a phospholipid-based transmembrane transport mechanism underlying the intracellular delivery of the FA-PC. This is the first report regarding FA-PC formation and its successful reversing of Gram-negative bacteria resistance to FA, and it provides a platform to reverse transmembrane delivery-related drug resistance. The ready availability of phospholipid and the simple preparation allow it to have great potential for clinical use.

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“…Non-crosslinked chitosan was deposited by freeze-drying from previously dissolved chitosan in 2% (w/v) acetic acid at different concentrations (1.0, 2.5, 5.0, and Metals 2023, 13, 1955 59 of 87 10 mg/mL). Promising results were obtained, as S. mutans bacterial adhesion decreased by up to 99.6% for coated brackets [511].…”

mentioning

confidence: 94%

Corrosion of Fixed Orthodontic Appliances: Causes, Concerns, and Mitigation Strategies

Fróis,

Santos,

Louro

2023

Metals

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The orthodontic supply market is a prosperous billion-dollar industry, driven by an increasing demand for orthodontic appliances. The supremacy of metallic first-generation biomaterials is evident for manufacturing brackets, archwires, bands, and other components due to their well-recognized chemical inertness, spontaneous passivation, biocompatibility, and favorable mechanical properties combination. However, the oral cavity is the ultimate corrosion-promoting environment for any metallic material. In this work, the general picture of the intraoral degradation of fixed orthodontic appliances is first addressed, from the causes to the harmful effects and their oral clinical implications. Current mitigation strategies are also pointed out, including the alloys’ bulk composition adjustment combined with new and advanced manufacturing processes and/or their surface treatment or coating deposition. The versatile use of thin films and coatings stands out with different deposition technologies: Many in vivo and in vitro efforts have been devoted to oral aging, from monolithic to composite architectures and micro- to nano-scale materials, to meet the best and safest oral practice demands. Unfortunately, literature data suggest that even the existing commercially available protective coatings have drawbacks and are fallible. Further multidisciplinary research is still required to effectively mitigate the corrosion behavior of fixed orthodontic appliances.

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Prevention of bacterial biofilm formation on orthodontic brackets by non-crosslinked chitosan coating

Cited by 9 publications

References 31 publications

Photothermal and Photodynamic Synergistic Effect of the MXene/SnS₂ Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity

Photothermal and Photodynamic Synergistic Effect of the MXene/SnS₂ Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity

Reversing the Natural Drug Resistance of Gram-Negative Bacteria to Fusidic Acid via Forming Drug–Phospholipid Complex

Corrosion of Fixed Orthodontic Appliances: Causes, Concerns, and Mitigation Strategies

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Prevention of bacterial biofilm formation on orthodontic brackets by non-crosslinked chitosan coating

Cited by 9 publications

References 31 publications

Photothermal and Photodynamic Synergistic Effect of the MXene/SnS2 Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity

Photothermal and Photodynamic Synergistic Effect of the MXene/SnS2 Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity

Reversing the Natural Drug Resistance of Gram-Negative Bacteria to Fusidic Acid via Forming Drug–Phospholipid Complex

Corrosion of Fixed Orthodontic Appliances: Causes, Concerns, and Mitigation Strategies

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Product

Resources

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Photothermal and Photodynamic Synergistic Effect of the MXene/SnS₂ Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity

Photothermal and Photodynamic Synergistic Effect of the MXene/SnS₂ Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity