Prevention of asthma

Kaufman, Herbert S.; Frick, Oscar L.

doi:10.1111/j.1365-2222.1981.tb02173.x

Cited by 37 publications

(6 citation statements)

References 4 publications

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“…The study confirmed the higher incidence of atopy among males. The results for breast-feeding contradict the claimed protection role for it [8][9][10][11]. The result may be due to the subjects' self selection.…”

Section: Discussionmentioning

confidence: 60%

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An epidemiological study of atopy in children

Astarita

Harris²,

Fusco³

et al. 1988

Clin Experimental Allergy

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Summary A sample of 930 children, between 9 years and 15 years old from six Italian towns, were studied. Their family history of allergy, personal allergy and medical history, current allergy symptoms, exposure to environmental allergens, feeding as infants, and their parents’ occupations were recorded. They were skin‐prick tested (SPT) with a range of common allergens. A subject was defined as atopic if at least one SPT caused a weal greater than 3 mm diameter. The association between the recorded information and atopy was investigated by logistic multiple regression. Atopy was positively associated with: high density housing; medium or high exposure to environmental allergens; a history of rhinitis, asthma or atopic eczema; male gender; and a history of breast‐feeding. It was independent of infectious diseases, vaccinations and operations, social class and family history. Thus, there was no evidence of a genetic factor in atopy, other than sex.

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Section: Discussionmentioning

confidence: 60%

“…In children, infections and immunizations [7] have been claimed to worsen, and breast-feeding to reduce, allergy in some patients [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

An epidemiological study of atopy in children

Astarita

Harris²,

Fusco³

et al. 1988

Clin Experimental Allergy

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“…But there is still controversy regarding breast feeding and the development of allergic diseases in childhood [4-131. As recently reviewed [14], the disagreements mainly result from different methodological approaches and most of the prospective studies concur to indicate that exclusive breast feeding for a sufficient period of time significantly delays the onset and attenuates the symptoms of allergic diseases in highrisk newborns [3,[11][12][13]. The latter may be identified at birth on the basis of family history associated with either high IgE levels [15] and/or low T cell number in cord blood [ll].…”

Section: Presence Of Ige Suppressor Factors In Human Colostrummentioning

confidence: 99%

Presence of IgE suppressor factors in human colostrum

et al. 1986

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In spite of intensive investigations, the ability of breast feeding to delay and to attenuate atopic diseases in children remains debatable. This study documents a mechanism whereby breast feeding might interfere with the synthesis of IgE by breast-fed infants. Indeed, we show that colostrum contains IgE-binding factors (IgE-BF) capable of suppressing the in vitro synthesis of human IgE. Colostrum obtained from 15 donors was successively depleted of lipids and casein, filtered through Amicon XM50 membrane (mol. mass cut-off 50 kDa) and lyophilized. IgE-BF was demonstrated in such preparations by two different approaches, i.e. a classical rosette inhibition assay and Western blot analysis. In the first instance, lyophilized preparations of colostrum inhibited the binding of IgE-coated bovine erythrocytes to IgE recovered on the surface of RPMI 8866 lymphoblastoid cells. The rosette-inhibiting activity could be absorbed on IgE- but not on IgG-Sepharose 4B and it could be recovered in the eluate of IgE-Sepharose 4B. The molecular mass of IgE-BF was comprised between 10 to 20 kDa as estimated by gel filtration through a calibrated Sephadex G-75 column. After fractionation on 12% sodium dodecyl sulfate-polyacrylamide gel electrophoresis and transfer to nitrocellulose membrane, colostrum displayed one band of 14 kDa and reacted with radiolabeled IgE but not with IgG nor IgM. This 14-kDa band could be removed by absorbing colostrum with IgE- but not with IgG-Sepharose 4B. Most importantly, the colostrum IgE-BF suppressed the spontaneous in vitro synthesis of IgE by B lymphocytes derived from allergic donors without altering the production of IgM.

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“…Accumulating evidence exists to suggest that breast feeding may help protect infants from sudden infant death syndrome, 4 early infection, 5 –9 eczema, asthma and other atopic diseases 3 . 10 –13 In addition to the physical benefits of breast feeding, there has been growing interest in the extent to which breast feeding has social and cognitive benefits for children 14 –20 . In particular, considerable research attention has been given to the association between breast feeding and cognitive development.…”

Section: Introductionmentioning

confidence: 99%

Breast feeding and later psychosocial adjustment

Fergusson

1999

Paediatric Perinatal Epid

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The relationship between the duration of breast feeding and psychosocial outcomes measured between the ages of 15 and 18 years was examined in a birth cohort of 999 New Zealand children. During the period from birth to 1 year, information was collected on maternal breast-feeding practices. Between the ages of 15 and 18 years, sample members were assessed using a range of psychosocial measures, including measures of the quality of parent-child relationships, juvenile delinquency, substance abuse and mental health. Children who were breast fed for a longer duration were more likely to report higher levels of parental attachment and tended to perceive their mothers as being more caring and less overprotective towards them compared with bottle-fed children. No association was found between the extent of breast feeding and subsequent rates of juvenile offending, substance use and mental health in later life. Mothers who elected to breast feed were also more likely to be older, better educated, living with a partner, less likely to smoke during pregnancy, and to come from advantaged socio-economic backgrounds characterised by better living standards and a higher family income. Rates of breast feeding were also greater among mothers who gave birth to a first-born child of higher birthweight. After adjustment for these maternal and perinatal factors, the duration of breast feeding remained significantly associated with adolescent perceptions of maternal care, with increasing duration of breast feeding being associated with higher levels of perceived maternal care during childhood. It is concluded that: (a) it is unlikely that breast feeding is associated with reduced risks of psychiatric disorder in later life; (b) breast feeding may lead to closer parent-child relationships; and (c) it is unlikely that the association between breast feeding and cognitive development is mediated by intervening processes relating to improved psychosocial adjustment in breast-fed children.

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Prevention of asthma

Cited by 37 publications

References 4 publications

An epidemiological study of atopy in children

An epidemiological study of atopy in children

Presence of IgE suppressor factors in human colostrum

Breast feeding and later psychosocial adjustment

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