Prevention of aspecifically induced bronchoconstriction by PGI2 and 20-methyl-PGI2 in asthmatic patients

Plasma Prostaglandin Levels from Bronchial Asthmatic Patients Assayed by 9-Anthryldiazomethane-HPLC Method

“…Plasma levels of 6-keto-PGF1,, hydrolysis product of PGIz, were less in the patients with spontaneous attacks than those in the patients without the attacks. Even though it has been reported that inhaled PG12 has little intrinsic bronchodilator activity in bronchial asthmatic subjects (131, PG12 is also shown to prevent methacholine-induced bronchoconstriction (14,151. The decreased levels of PGIz may affect the asthmatic conditions.…”

Prostacyclin‐analogs

“…47 However, prostacyclin protected against allergen-induced bronchoconstriction in only 3 out of 10 patients. 48 Prostacyclin exerts a cytoprotective effect in ischemically damaged myocardial t i s s~e .~~,~~ which in addition to its vasodilatory and anti-aggregatory e f f e~t s~l ,~~ may be related to the inhibition of catecholamine release53 and a membrane stabilizing a~t i o n .~~,~~ Prostacyclin is also cytoprotective in the stomach where it protects the mucosa against erosion and reduces gastric acid secretion.…”

“…Cyclization of the acetylenic alcohol 46 followed by cleavage of the silyl ether with fluoride, Jones-Qxidafion and hydrolysis gave the 4,5-tetradehydro PGI, analog 47, whereas cyclization, hydrogenation, silyl ether cleavage, JonesOxidation, and hydrolysis afforded the cis-4,5-dehydro derivative 48. However, no biological data for 47 and 48 were rep~rted.…”

Effects of Prostacyclin and Beraprost on Ciliary Motilitγ of Rabbit Airway Epithelium

“…Therefore, it seems reasonable to speculate that the observed increase in CBF can be translated into enhanced mucociliary trans port, as predicted by theoretical models of mucociliary' pumping [14]. Application of prostacyclin has also been reported to relax airway smooth muscle [4] and prevent the bronchoconstrictor effect of ultrasonic mist and exercise in asthmatic sub jects [15]. However, physiological importance of endogenously released prostacyclin into the airways remains uncertain.…”