Prevention of allergic sensitization by environmental control

Simpson, Angela; Čustović, Adnan

doi:10.1007/s11882-009-0053-y

Cited by 23 publications

(15 citation statements)

References 47 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a group of 120 non-sensitised, high-risk infants, avoiding house dust mites by using mattress covers proved successful in preventing allergic asthma [102]; at 18 years old, this group still had a lower prevalence of asthma than the control group [103]. In sharp contrast, other trials found that allergen avoidance produced no or even deleterious effects [104][105][106]. Taken together, these studies fail to support a role for either allergen avoidance or allergen exposure in preventing the inception of allergic airway disease.…”

Section: Allergic Sensitisationmentioning

confidence: 99%

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

et al. 2014

View full text Add to dashboard Cite

Chronic obstructive respiratory disorders such as asthma and chronic obstructive pulmonary disease often originate early in life. In addition to a genetic predisposition, prenatal and early-life environmental exposures have a persistent impact on respiratory health. Acting during a critical phase of lung development, these factors may change lung structure and metabolism, and may induce maladaptive responses to harmful agents, which will affect the whole lifespan.Some environmental factors, such as exposure to cigarette smoke, type of childbirth and diet, may be modifiable, but it is more difficult to influence other factors, such as preterm birth and early exposure to viruses or allergens.Here, we bring together recent literature to analyse the critical aspects involved in the early stages of lung development, going back to prenatal and perinatal events, and we discuss the mechanisms by which noxious factors encountered early on may have a lifelong impact on respiratory health.We briefly comment on the need for early disease biomarkers and on the possible role of ''-omic'' technologies in identifying risk profiles predictive of chronic respiratory conditions. Such profiles could guide the ideation of effective preventive strategies and/or targeted early lifestyle or therapeutic interventions. @ERSpublications Early-life factors have a role in onset of asthma and COPD; early postnatal interventions may promote lung health http://ow.ly/BvUrx

show abstract

Section: Allergic Sensitisationmentioning

confidence: 99%

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

et al. 2014

View full text Add to dashboard Cite

show abstract

“…As described previously, the majority of school age children and adults with asthma have concomitant allergic sensitization, and a number of studies have associated allergic sensitization with asthma inception and severity. To date, efforts to decrease allergen exposures as a strategy to prevent allergen sensitization or asthma have been generally unsuccessful (54). This may be because of the difficulty in eliminating aeroallergen exposures, concomitant elimination of helpful microbial exposures, or because allergic sensitization is associated with the disease pathway but not causal.…”

Section: Prevention Of Rsv and Rv Early Life Lower Respiratory Tract mentioning

confidence: 99%

Asthma: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases

et al. 2014

View full text Add to dashboard Cite

Asthma is a common disease with enormous public health costs, and its primary prevention is an ambitious and important goal. Understanding of how host and environmental factors interact to cause asthma is incomplete, but persistent questions about mechanisms should not stop clinical research efforts aimed at reducing the prevalence of childhood asthma. Achieving the goal of primary prevention of asthma will involve integrated and parallel sets of research activities in which mechanism-oriented studies of asthma inception proceed alongside clinical intervention studies to test biologically plausible prevention ideas. For example, continued research is needed, particularly in young children, to uncover biomarkers that identify asthma risk and provide potential targets of intervention, and to improve understanding of the role of microbial factors in asthma risk and disease initiation. In terms of clinical trials that could be initiated now or in the near future, we recommend three interventions for testing: (1) preventing asthma through prophylaxis against respiratory syncytial virus and human rhinovirus infections of the airway; (2) immune modulation, using prebiotics, probiotics, and bacterial lysates; and (3) prevention of allergen sensitization and allergic inflammation, using anti-IgE. These interventions should be tested while other, more universal prevention measures that may promote lung health are also investigated. These potential universal lung health measures include prevention of preterm delivery; reduced exposure of the fetus and young infant to environmental pollutants, including tobacco smoke; prevention of maternal and child obesity; and management of psychosocial stress.

show abstract

“…Over the past 2 decades, knowledge of how to reduce exposure to indoor asthma triggers has increased dramatically. 7,[30][31][32][33][34][35][36][37][38][39][40][41] Single-trigger interventions generally ineffective Initial approaches for reducing trigger exposure focused on individual triggers. They generally have had minimal to no success.…”

Section: Interventions To Reduce Exposure To Triggersmentioning

confidence: 99%

Home is Where the Triggers Are: Increasing Asthma Control by Improving the Home Environment

Krieger

2010

Pediatric Allergy, Immunology, and Pulmonology

View full text Add to dashboard Cite

Asthma remains the most common chronic condition of childhood. Strong evidence has linked exposure to allergens and other triggers commonly found in homes to allergen sensitization and asthma incidence and morbidity. A growing body of evidence has demonstrated that a home visit strategy that includes an environmental component that addresses multiple triggers through multiple interventions is effective. Such home visits reduce exposure to triggers, decrease symptoms and urgent health-care use, and increase quality of life. To make home visits widely available will require health-care payor reimbursement, government and health plan funding, training and certification of home visitors, and active referrals from health-care providers. However, a strategy based solely on education and behavior change is limited, because it cannot adequately reduce exposures due to adverse housing conditions. Therefore, approaches that address substandard housing are needed. These include remediation of existing housing and construction of new asthma-friendly homes. Most studies of remediation have made relatively narrow and focused improvements, such as insulation, heating, or ventilation. Outcomes have been mixed. Studies of new asthma-friendly homes are in their infancy, with promising pilot data. Further investigation is needed to establish the effectiveness of improving housing. A final strategy is improving housing quality through policy change, such as implementation of healthy housing guidelines for new construction, enhancement and increased enforcement of housing codes, and assuring smoke-free multi-unit homes. The combination of home visits, improved housing construction, and policy change has great potential for reducing the global burden of asthma.

show abstract

Prevention of allergic sensitization by environmental control

Cited by 23 publications

References 47 publications

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

Asthma: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases

Home is Where the Triggers Are: Increasing Asthma Control by Improving the Home Environment

Contact Info

Product

Resources

About