Prevention of Adhesions with Crystalloids during Laparoscopic Surgery in Mice

Elkelani, Osama; Molinas, Carlos Roger; Mynbaev, Ospan A.; Koninckx, Philippe

doi:10.1016/s1074-3804(05)60517-8

Cited by 29 publications

(21 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, Elkelani et al [14] confirmed that adhesiogenesis mechanisms were different after laparoscopy and laparotomy. For that purpose, CO 2 pneumoperitoneum appears like a cofactor in adhesion formation [9,15].…”

Section: Discussionmentioning

confidence: 99%

Efficiency of TachoSil® to prevent postsurgical adhesion development on laparoscopic rat model

Nohuz¹,

Darcha

Moreno³

et al. 2009

Gynecol Surg

View full text Add to dashboard Cite

The aim of this study was to evaluate the effectiveness of a fibrinogen and thrombin-coated hemostatic sponge (TachoSil®) in the prevention of postsurgical adhesions in a laparoscopic rat model and its histological effects on uterine and peritoneal parenchyma. Design was a prospective randomized blinded study. Setting was in International Laparoscopic Surgery Centre, ClermontFerrand, France. There were 100 sexually mature female Sprague-Dawley rats weighing 240 to 300 g and aged 6-8 weeks. A standardized severe surgical injury induced by scissors and 40-W bipolar coagulation in the rat uterine horn, corpus, and peritoneum was performed to induce adhesion formation. After trauma, group 1 (n=50) received no treatment and group 2 rats (n=50) received TachoSil® applied on injured areas. Twelve weeks after the procedure, repeat laparoscopy was performed and adhesions were scored according to their extent and severity. A hysterectomy and a peritoneal biopsy in the injured area were achieved by laparotomy in order to investigate on a possible earlier effect of TachoSil® on the uterine and peritoneal parenchyma in 49 rats of each group. TachoSil® group adhesion scores showed a significant decrease on the three injured areas: peritoneum (12.96 vs. 21.66), uterine horn (7.22 vs. 15.20), and uterine corpus (5.88 vs. 34.52). TachoSil® group also demonstrated a major decline of uterine fibrosis and inflammation. This study revealed that TachoSil®, an absorbable biomaterial, can reduce postoperative adhesions after laparoscopic surgery on a rat model. TachoSil® also prevents thermo-induced injuries on uterine parenchyma (less fibrosis and less inflammation).

show abstract

Section: Discussionmentioning

confidence: 99%

Efficiency of TachoSil® to prevent postsurgical adhesion development on laparoscopic rat model

Nohuz¹,

Darcha

Moreno³

et al. 2009

Gynecol Surg

View full text Add to dashboard Cite

show abstract

“…The experimental setup (i.e., animals, anesthesia, ventilation, laparoscopic surgery, and induction and adhesion scoring) has been described in detail elsewhere (4,5,(21)(22)(23)(24)(25). The model consisted of a bipolar lesion made at the begining of a 60 minutes pneumoperitoneum during laparoscopy.…”

Section: Materials and Methods Laparoscopic Mouse Model For Adhesion mentioning

confidence: 99%

Postoperative inflammation in the abdominal cavity increases adhesion formation in a laparoscopic mouse model

Corona

Verguts

Schonman

et al. 2011

Fertility and Sterility

Self Cite

View full text Add to dashboard Cite

“…The experimental setup (i.e., animals, anesthesia and ventilation, laparoscopic surgery, and induction and scoring of intraperitoneal adhesions) has been described in detail previously [49,[71][72][73][74][75][76][77]. Briefly, the model consisted of pneumoperitoneum-enhanced adhesions induced during laparoscopy by creation of a mechanical lesion.…”

Section: The Laparoscopic Mouse Model For Adhesion Formationmentioning

confidence: 99%

“…Some products have been demonstrated to decrease postoperative adhesions during laparoscopy including antibodies against vascular endothelial growth factor receptor 1 (VEGF-R1) [48], crystalloids [49,50], 4% icodextrin [50], ferric hyaluronate gel [50][51][52], Sepracoat [53], a crosslinked hyaluronan solution [54], and hyaluronate membrane [55].…”

mentioning

confidence: 99%

Effect of reactive oxygen species scavengers, antiinflammatory drugs, and calcium-channel blockers on carbon dioxide pneumoperitoneum-enhanced adhesions in a laparoscopic mouse model

Binda

Molinas²,

Bastidas

et al. 2007

Surg Endosc

View full text Add to dashboard Cite

show abstract

Prevention of Adhesions with Crystalloids during Laparoscopic Surgery in Mice

Cited by 29 publications

References 15 publications

Efficiency of TachoSil® to prevent postsurgical adhesion development on laparoscopic rat model

Efficiency of TachoSil® to prevent postsurgical adhesion development on laparoscopic rat model

Postoperative inflammation in the abdominal cavity increases adhesion formation in a laparoscopic mouse model

Effect of reactive oxygen species scavengers, antiinflammatory drugs, and calcium-channel blockers on carbon dioxide pneumoperitoneum-enhanced adhesions in a laparoscopic mouse model

Contact Info

Product

Resources

About