Prevention of Accelerated Cell Aging in the Werner Syndrome

Davis, Terence; Haughton, Michele Fleur; Jones, Christopher J.; Kipling, David

doi:10.1196/annals.1354.031

Cited by 33 publications

(28 citation statements)

References 11 publications

(31 reference statements)

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“…There is no effective treatment for WS. It has been reported that p38 MAPK activation causes stress-induced premature senescence (SIPS) and p38 selective inhibitor molecule SB203580 may increase the growth and life span of fibroblasts (28,29). This data suggest that further studies are necessary to identify new targets for the treatment of premature aging.…”

Section: Discussionmentioning

confidence: 97%

Early Onset Werner Syndrome

Aydoğan¹,

Ünlütürk²,

Demir³

et al. 2015

tjem

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Section: Discussionmentioning

confidence: 97%

Early Onset Werner Syndrome

Aydoğan¹,

Ünlütürk²,

Demir³

et al. 2015

tjem

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“…For this reason "natural" ageing has also been described as a consequence of chronic inflammation. In fact the term "Inflame-Aging" has been coined based on experimental evidence that has been demonstrated in the context of characterizing the molecular events in the classical Werner´s progeria syndrome [91,92]. MSC in vivo recruitment to the synovial surface has recently been demonstrated in patients with osteoarthritis [93].…”

Section: Immunomodulationmentioning

confidence: 99%

Biology of Mesenchymal Stem Cells

Jakob¹,

Limbert²,

Schilling³

et al. 2008

CRR

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Mesenchymal stem cells (MSC) are derived from mesodermal precursor and are committed towards mesenchymal differentiation. They are scattered all over the organism, situated in bone, cartilage, adipose tissue and accompany organs for tissue regeneration and structural and functional support. MSC populations are not homogenous, their signature is variable according to their localization. A process called "epithelial mesenchymal transition" is fundamental for the development of mesoderm. Epithelial-mesenchymal interactions specify MSC and this may influence their regeneration potential. Multipotent adult MSC are used for research in tissue regeneration and engineering. Crude mixtures of bone marrow-derived MSC are clinically applied for tissue healing, but complex transplantable tissue engineered constructs are still under development. The role and regeneration potential of MSC in inflammation and ageing organisms remains to be characterized. The establishment of reprogrammed homogenous MSC cultures of high plasticity might allow developing these cells towards multiple cell-based therapeutic strategies. Many applications can be envisioned, e.g. regeneration of bone, cartilage and tendon or engineering of beta cells and neurons. Since homogenous MSC with high plasticity represent a promising tool for the treatment of many diseases, research in this area of adult stem cells should be supported with high priority.

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“…Intrinsic factors include telomeres which are shortened with each replication cycle until they reach a critical short length at which time they signal for apoptosis [4]. The effect of telomere shortening on aging is supported by the fact that they are shorter in patients with premature aging syndromes such as Werner syndrome [5]. DNA damage and defects in DNA repair mechanisms are also thought to play a role in aging.…”

Section: Introductionmentioning

confidence: 99%

Skin Manifestations of Internal Disease in Older Adults

Markus¹,

Perry²,

Lear³

2015

Curr Geri Rep

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The skin is the largest and most visible organ in the body and can give diagnostic clues of systemic illness. These clues often become obscured through the normal aging process. The purpose of this review is to give an overview of the normal skin changes seen with aging and then discuss new findings with regards to cutaneous signs of systemic disease in the elderly. We performed a literature search on cutaneous manifestations of internal disease and limited our search to articles published within the last 5 years. We then narrowed down the articles on conditions that primarily affect the adults over the age of 65; conditions commonly seen in the elderly as well as new findings which we felt were of great significance. Ultimately, we hope to update the reader on new cutaneous diagnostic tools of internal disease.

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Prevention of Accelerated Cell Aging in the Werner Syndrome

Cited by 33 publications

References 11 publications

Early Onset Werner Syndrome

Early Onset Werner Syndrome

Biology of Mesenchymal Stem Cells

Skin Manifestations of Internal Disease in Older Adults

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