Prevention Conference V

Greenland, Philip; Abrams, Jonathan; Aurigemma, Gerard P.; Bond, M. Gene; Clark, Luther T.; Criqui, Michael H.; Crouse, John R.; Friedman, Lawrence M.; Fuster, Valentín; Herrington, David M.; Kuller, Lewis H.; Ridker, Paul M.; Roberts, William C.; Stanford, William; Stone, Neil J.; Swan, H.J.C.; Taubert, Kathryn A.; Wexler, Lewis

doi:10.1161/01.cir.101.1.e16

Cited by 665 publications

(173 citation statements)

References 80 publications

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“…In adults, cIMT measurement is considered a valid and reliable assessment of atherosclerotic burden (15,28) that can predict coronary atherosclerosis and its clinical sequelae, such as myocardial infarction and stroke (14,28). In fact, the Atherosclerosis Risk in Communities study demonstrated that among adults aged 45-64 years without clinical coronary heart disease at baseline, those with a cIMT $1 mm had a significantly increased hazard for development of coronary heart disease (5.07 for women [95% CI, 3.08-8.36] and 1.85 for men [95% CI, 1.28-2.69]) over the next 4-7 years compared with those with a cIMT ,1 mm (29).…”

Section: Discussionmentioning

confidence: 99%

Carotid Intima-Media Thickness in Children with CKD

Brady¹,

Schneider²,

Flynn³

et al. 2012

Clinical Journal of the American Society of Nephrology

102

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SummaryBackground and objectives In adults, increased carotid intima-media thickness (cIMT) as assessed by ultrasonography is a valid predictor of cardiovascular events. Children with CKD are known to be at increased cardiovascular risk. This study sought to identify cardiovascular risk factors associated with increased cIMT in children with CKD. Results The median cIMT was 0.43 mm (interquartile range, 0.38-0.48) compared with 0.41 mm in healthy controls (P=0.03 for difference). After multivariable adjustment, the median cIMT was 0.02 mm (95% confidence interval [CI], 0.01-0.05) larger than that of the healthy controls. In a multivariable linear regression analysis, dyslipidemia and hypertension were associated with 0.05 mm (95% CI, 0.01-0.08) and 0.04 mm (95% CI, 0.003-0.08) greater mean cIMT, respectively. Body mass index, CKD etiology, GFR, birth weight, pubertal status, calcium, phosphorus, sex, and race were not associated with cIMT.Conclusions cIMT is significantly elevated among children with CKD, as is the prevalence of other cardiovascular risk factors. Of these risk factors, hypertension and dyslipidemia are significantly associated with increased cIMT.

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Section: Discussionmentioning

confidence: 99%

Carotid Intima-Media Thickness in Children with CKD

Brady¹,

Schneider²,

Flynn³

et al. 2012

Clinical Journal of the American Society of Nephrology

102

View full text Add to dashboard Cite

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“…[4][5][6] Although ultrasound measurement of CIMT has been recommended as a clinical screening tool, its use has been limited to research studies or selected institutions, in part because of labor-and time-intensive measurement protocols. 7 An analysis package that allows straightforward and efficient measurement of CIMT, while maintaining accuracy and reproducibility, could be a useful clinical tool.…”

mentioning

confidence: 99%

Validation of a Carotid Intima-Media Thickness Border Detection Program for Use in an Office Setting

Gepner

Korcarz

Aeschlimann

et al. 2006

Journal of the American Society of Echocardiography

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Background: A unique semiautomated border detection program (BDP) designed for use on a personal computer was evaluated to determine whether: (1) carotid intima-media thickness (CIMT) measurements were bioequivalent to a reference laboratory; and (2) it would allow a novice (NOV) reader with no medical training to accurately and reproducibly measure CIMT. Methods: Far-wall CIMT was measured blindly and in duplicate by an experienced and NOV reader using BDP and by a reference laboratory.

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“…In each patient the Ankle-Brachial Index (ABI) was evaluated by a senior physician according to current recommendations and carefully standardized procedures were followed in the non-invasive vascular diagnostic lab of the Lipid Clinic [10] and [22]. Briefly, with the patient in supine position, BP cuffs were applied to both upper and lower limbs and the systolic BP was measured using an 8-Mhz Doppler probe and an ultrasonic Doppler flow detector.…”

Section: Ankle-brachial Indexmentioning

confidence: 99%

Implications of routinely measuring Ankle-Brachial Index (ABI) among patients attending at a Lipid Clinic

Sona

Comba

Brescianini

et al. 2009

European Journal of Internal Medicine

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The definitive versionisavailableat:La versione definitiva è disponibile alla URL: [http://www.sciencedirect.com/science/article/pii/S0953620508002677?via=ihub] Implications of routinely measuring Ankle-Brachial Index (ABI) among patients attending at a Lipid Clinic Alessandro Sona, Monica Comba, Alessia Brescianini, Laura Corsinovi, Mauro Zanocchi, Gianfranco Fonte, Mario BoCorresponding author contact information, E-mail the corresponding author Abstract BackgroundLow (≤ 0.90) Ankle Brachial Index (ABI) values identify patients at high risk for cardiovascular (CV) disease and mortality. Implications for CV risk classification from routinely measuring ABI in the context of a Lipid Clinic have not been fully investigated. We aimed to evaluate whether and to what extent routine ABI determination on top of conventional risk prediction models may modify CV risk classification. MethodsConsecutive asymptomatic non-diabetic individuals free from previous CV events attending for a first visit at a Lipid Clinic underwent routine ABI determination and conventional CV risk classification according either to national CUORE model (including age, gender, smoking, total and high density lipoprotein cholesterol, systolic blood pressure and current use of blood pressure lowering drugs) and SCORE model for low risk countries. ResultsIn the overall sample (320 subjects, mean age 64.8 years) 77 subjects (24.1%) were found to have low ABI value. Forty-two of 250 subjects (16.8%) and 47 of 215 individuals (21.3%) at low or moderate risk according to the CUORE and SCORE models, respectively, were found to have low ABI values, and should be reclassified at high risk. ConclusionIn a series of consecutive asymptomatic individuals in a Lipid Clinic, we observed a high prevalence of low ABI values among subjects deemed at low or moderate risk on conventional prediction models, leading to CV high-risk reclassification of roughly one fifth of patients. These findings reinforce recommendations for routine determination of ABI at least within referral primary prevention settings.

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Prevention Conference V

Cited by 665 publications

References 80 publications

Carotid Intima-Media Thickness in Children with CKD

Carotid Intima-Media Thickness in Children with CKD

Validation of a Carotid Intima-Media Thickness Border Detection Program for Use in an Office Setting

Implications of routinely measuring Ankle-Brachial Index (ABI) among patients attending at a Lipid Clinic

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