Prevention and Treatment of Viral Hepatitis

Iber, Frank L.

doi:10.1001/archinte.1962.03620150060011

Cited by 18 publications

(5 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8 Age wise supplementation of calories and protein is very important for the growth of child for growth and also for recovery during illness. 7,9,10 In our study, in a series of 50 children recruited, majority children were male (80%). Only 10 (20%) were female.…”

Section: Discussionmentioning

confidence: 54%

Old dietary cultural practices leading to suboptimal nutritional intake of calories in children with acute viral hepatitis

Bharti

Neelu

2020

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Acute viral hepatitis (AVH) is one of the common infections in developing nation. Hepatotrophic virus causes AVH and most of the time it has self-limiting course. HAV is most common cause of AVH. Suboptimal dietary cultural practices are common in our nation. This study was done to know the impact of suboptimal dietary practices done in AVH.Methods: Observational study conducted with 50 children with AVH. Dietary assessment was done at three point of time. First During AVH, second, pre illness and then two weeks after nutritional counselling. Data of dietary modification done by parents/caregiver during AVH recorded. History of herbal medicine taken for treatment of AVH enquired.Results: HAV positive was (72%), HEV positivity was in 8 (16%) cases, hepatitis B was positive in 4 (8%) children and dual infection HAV+HEV was detected in 2 (4%) children. Many parents did dietary modification due to AVH and also by some local treating physicians, 18 (36%) patients were also on herbal medication for treatment of AVH. During AVH the mean calorie and protein requirement decreased from 96% to 54% and 92% to 43% respectively. Two weeks after nutritional counseling the mean calorie and protein intake increased from 54% to 88% and 43% to 84% respectively. This change in calorie and protein was statistically significant (p<0.01) Non-vegetarian diet preference was restarted in many of them after nutritional counseling.Conclusions: This observational study revealed that suboptimal dietary cultural practices are prevalent in India. Majority of children were on bland diet and receiving inadequate proteins and calories.

show abstract

Section: Discussionmentioning

confidence: 54%

Old dietary cultural practices leading to suboptimal nutritional intake of calories in children with acute viral hepatitis

Bharti

Neelu

2020

Int J Contemp Pediatr

View full text Add to dashboard Cite

show abstract

“…Adequate nutrition is important and a well‐balanced normal diet with increased calories and proteins needs to be taken to meet the energy demands of the tissue regeneration process [10,11]. While it is known that low fat diets are associated with extended and complicated illness [6] such diets are still widely used which could lengthen patient hospitalization and contribute to additional costs.…”

Section: Discussionmentioning

confidence: 99%

Dietary alterations due to perceptions in acute viral hepatitis lead to sub-optimal calorie intake and increased length of hospitalization

Sathiaraj

Chutke

Mahurkar

et al. 2010

Journal of Viral Hepatitis

View full text Add to dashboard Cite

Although there are no dietary restrictions recommended in acute viral hepatitis (AVH), there is an altered food intake, probably because of perceptions and traditional nutritional practices, leading to sub-optimal intake and poorer clinical outcome. Therefore, we aimed to determine nutritional intake of AVH patients before and after disease onset and to investigate if optimal intake following nutrition education shortened the length of hospitalization (LOH). Seventy-five patients with AVH were interviewed for foods consumed and avoided because of perceptions during illness. Nutrition education was given to all patients with meal plan. In-patients were monitored for their nutritional intake until discharge. All patients were followed up after 2 weeks to assess compliance to the plan. There was a statistically significant decrease in mean calorie and protein intake in AVH patients during illness [1314 kcal (standard deviation, SD 291) and 27.5 g (SD 8.84)] when compared with that before onset of the disease [1873 kcal (SD 246) and 51.5 g (SD 8.03); P < 0.0001]. Mean LOH in patients consuming a high calorie diet [6.28 days (SD 2.91)] was significantly lower than those consuming low calories [8.36 days (SD 2.59), P = 0.024]. Two-week follow up revealed that 70% of patients modified their diet to a balanced normal diet as per the given plan. Our study showed that AVH patients consumed sub-optimal calories because of perceptions and traditional nutritional practices. Nutrition education played a major role in achieving overall nutritional goals and in decreasing the LOH.

show abstract

“…In the acute phase of carbon tetrachloride injury, Aterman and Ahmad (1953) found that the degenerative changes in the liver cells of cortisonetreated rats were much more extensive than in untreated controls. In other types of liver injury, for example, human infective hepatitis, the therapeutic value of corticosteroids has been controversial (Iber and Mendeloff, 1962;Katz et al, 1962).…”

Section: Discussionmentioning

confidence: 99%

Effect of prednisolone on liver damage in rats induced by aflatoxin

Madhavan

1967

J. Pathol.

View full text Add to dashboard Cite

PLATES CXII AND CXIII THE susceptibility of the young albino rat to the hepatotoxic action of aflatoxin is markedly enhanced by feeding it on protein-deficient diets (Madhavan and Gopalan, 1965). The effect of prednisolone on this form of toxic liver injury is now reported. MATERIALS AND METHODSTwo experiments, each on a number of test groups as detailed below, were carried out on equal numbers of male and female 28-to 31-day-old stock weanling albino rats, each weighing about 40-50 g. Prednisolone acetate (Deltacortd) in aqueous solution was administered orally with a dropper to each animal in test groups 3,4,5 and 6 (see below); the dosage was 1 mg. per rat per day in experiment 1 and 0.2 mg. per rat per day in experiment 2.Pure crystalline aflatoxin (kindly supplied by Dr P. C. Spensely of the Tropical Products Institute, London) was dissolved in propylene glycol and also given orally with a dropper. Each rat in the test groups 1,2,3 and 4 (see below) received one daily drop containing 70 pg. of the toxin.Two diets were employed and these differed only in protein content, which was 20 per cent. in one and 5 per cent. in the other. The diets were adequate in other nutrients, and included lard ( 5 per cent.), corn starch, vitamin and salt mixtures. The protein source was casein. The detailed composition of the diet is given elsewhere (Madhavan and Gopalan).The different groups of animals in both experiments were given aflatoxin or prednisolone acetate or both, as described above, from the first day, according to the following plan : Group I-high protein diet +aflatoxin; Group 2-low protein diet +aflatoxin; Group 3-high protein diet +aflatoxin +prednisolone acetate; Group 4-low protein diet taflafoxin +prednisolone acetate: Group 5-high protein diet +prednisolone acetate: Group 6-low protein diet +prednisolone acetate; Group 7-high protein diet alone; Group 8-Iow protein diet alone.Care was taken to allot littermates to comparable groups as far as possible, each group consisting of 8-10 rats.The toxin and the steroid were given immediately before placing the diets in the rat cages.In experiment 1 it was found that there wereno differences between groups 5 and 7 and groups 6 and 8 in respect of growth, food intake and liver histology. Hence groups 7 and 8 were omitted in experiment 2. J. PATH. BACT.-VOL. (1967) 443 93

show abstract

Prevention and Treatment of Viral Hepatitis

Cited by 18 publications

References 72 publications

Old dietary cultural practices leading to suboptimal nutritional intake of calories in children with acute viral hepatitis

Old dietary cultural practices leading to suboptimal nutritional intake of calories in children with acute viral hepatitis

Dietary alterations due to perceptions in acute viral hepatitis lead to sub-optimal calorie intake and increased length of hospitalization

Effect of prednisolone on liver damage in rats induced by aflatoxin

Contact Info

Product

Resources

About