Prevention and treatment of venous thromboembolism

Kakkar, Chandan

doi:10.1016/0268-9499(90)90219-a

Cited by 7 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 When venography or radiolabelled fibrinogen is used in asymptomatic postoperative patients, more than 20% of them are found to have evidence of DVT. 2,3 In acute setting, a thrombus in deep veins can lead to development of pulmonary embolism (PE). Such an episode can be fatal, and often, this is the first manifestation of a venous thromboembolic event (VTE).…”

Section: Introductionmentioning

confidence: 99%

Incidence of Postoperative Deep Venous Thrombosis Is Higher among Cardiac and Vascular Surgery Patients as Compared with General Surgery Patients

Aziz

Patel

Ortenzi

et al. 2015

Annals of Vascular Surgery

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Incidence of Postoperative Deep Venous Thrombosis Is Higher among Cardiac and Vascular Surgery Patients as Compared with General Surgery Patients

Aziz

Patel

Ortenzi

et al. 2015

Annals of Vascular Surgery

View full text Add to dashboard Cite

“…Specific tests disclose deep venous thrombosis in about a quarter of all patients who have had general surgery and in about half of those who have had orthopaedic surgery 1. Most such thromboses are subclinical and resolve completely when mobility is restored (though a few produce permanent valvular damage and chronic venous insufficiency), but some may embolise to the lungs, producing slight, substantial, or fatal effects.…”

Section: Introductionmentioning

confidence: 99%

Collaborative overview of randomised trials of antiplatelet therapy - III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients

1994

BMJ

471

View full text Add to dashboard Cite

Objective : To determine the efficacy of antiplatelet therapy as prophylaxis against deep venous thrombosis or pulmonary embolism in surgical and high risk medical patients. Design : Overviews of all randomised trials of antiplatelet therapy that could have been available by March 1990 and in which deep venous thrombosis was assessed systematically. Setting : 53 trials (total 8400 patients) of an average of two weeks of antiplatelet therapy versus control in general or orthopaedic surgery; nine trials (600 patients) of antiplatelet therapy versus control in other types of immobility; 18 trials (1000 patients) of one antiplatelet regimen versus another. Results : Overall, a few weeks of antiplatelet therapy produced a highly significant (2P < 0.00001) reduction in deep venous thrombosis. 25% of patients allocated antiplatelet therapy versus 34% of appropriately adjusted controls had deep venous thrombosis detected by systematic fibrinogen scanning or venography, representing prevention in about 90 patients per 1000 allocated antiplatelet therapy. There was an even greater proportional reduction in pulmonary embolism: such emboli were detected among 47 (1.0%) antiplatelet allocated patients versus an adjusted control total of 129 (2.7%), representing prevention among about 17 patients per 1000 treated (2P < 0.00001). In analyses confined to surgical trials, the proportional reductions were similar and separately significant for nonfatal pulmonary embolism (0.7% antiplatelet therapy upsilion 1.8% control; 2P < 0.00001) and for deaths attributed to pulmonary embolism (0.2% upsilion 0.9%; 2P = 0.0001). There was a slight but non - significant excess of deaths from other causes (1.0% upsilion 0.7%), which made the difference in total mortality non-significant, though still favourable (1.2% upsilion 1.5%). Information on adding antiplatelet therapy to heparin was limited but, at least for pulmonary embolism, suggested more protection from the combination than from heparin alone. Conclusion : It had previously been supposed that antiplatelet therapy did not influence venous thromboembolism, and many surgeons and physicians do not use it routinely for thromboprophylaxis, even for patients who are at substantial risk of deep venous thrombosis or pulmonary embolism. These results indicate that antiplatelet therapy - either alone or, for greater effect, in addition to other proved forms of thromboprophylaxis (such as subcutaneous heparin) - should be considered.

show abstract

“…Sie ist jedoch mit einer hohen Morbidität und Sterblichkeit assoziiert (Dreißigtageletalität 18,7 vs. 3,3 % ohne Lungenarterienembolie, [76]). Tendenziell scheinen Lungenarterienembolien nach Bypass-oder kombinierten Klappen-Bypass-Operationen häufiger aufzutreten als nach isolierten Klappeneingriffen [90].…”

Section: Lungenarterienembolienunclassified

Gefäßerkrankungen und -komplikationen im Rahmen von Herzoperationen

Lüders

Reinecke

2015

Z Herz- Thorax- Gefäßchir

View full text Add to dashboard Cite

Prevention and treatment of venous thromboembolism

Cited by 7 publications

References 0 publications

Incidence of Postoperative Deep Venous Thrombosis Is Higher among Cardiac and Vascular Surgery Patients as Compared with General Surgery Patients

Incidence of Postoperative Deep Venous Thrombosis Is Higher among Cardiac and Vascular Surgery Patients as Compared with General Surgery Patients

Collaborative overview of randomised trials of antiplatelet therapy - III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients

Gefäßerkrankungen und -komplikationen im Rahmen von Herzoperationen

Contact Info

Product

Resources

About