Prevention and Management of Influenza in Pregnancy

Beigi, Richard H.

doi:10.1016/j.ogc.2014.08.002

Cited by 17 publications

(20 citation statements)

References 52 publications

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“…Much less is known about viruses that may not readily vertically transmit during pregnancy, like HSV-2 and influenza H1N1. However, such viruses may still impact maternal and fetal morbidity and mortality by infecting gestational tissues and modulating local innate immune responses(47–52). The results presented in this study indicate a herpes viral infection, that infects but does not cross the placenta (36, 39), sensitizes human FM tissue to low levels of bacterial LPS, giving rise to an exaggerated inflammatory IL-1β response.…”

Section: Discussionmentioning

confidence: 99%

Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation

Cross

Potter

Aldo

et al. 2017

The Journal of Immunology

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Chorioamnionitis, premature rupture of fetal membranes (FM), and subsequent preterm birth are associated with local infection and inflammation, particularly interleukin 1 beta (IL-1β) production. While bacterial infections are commonly identified, other microorganisms may play a role in the pathogenesis. Since viral pandemics, such as influenza, Ebola and Zika are becoming more common, and pregnant women are at increased risk of associated complications, this study evaluated the impact viral infection had on human FM innate immune responses. This study shows that a herpes viral infection of FMs sensitizes the tissue to low levels of bacterial lipopolysaccharide (LPS), giving rise to an exaggerated IL-1β response. Using an ex vivo human FM explant system and an in vivo mouse model of pregnancy, we report that the mechanism by which this aggravated inflammation arises is through the inhibition of the TAM receptor, MERTK, and activation of the inflammasome. The TAM receptor ligand, growth arrest specific 6 (GAS6), re-establishes the normal FM response to LPS by restoring and augmenting TAM receptor and ligand expression, and by preventing the exacerbated IL-1β processing and secretion. These findings indicate a novel mechanism by which viruses alter normal FM immune responses to bacteria, potentially giving rise to adverse pregnancy outcomes.

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Section: Discussionmentioning

confidence: 99%

Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation

Cross

Potter

Aldo

et al. 2017

The Journal of Immunology

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show abstract

“…[1][2][3][4] Pregnant women may be more susceptible to or more severely affected by certain viral pathogens, including influenza, because of pregnancy-related immunologic and anatomic/physiologic alterations. 5 Pregnant women with influenza are also at increased risk of premature labor and delivery. 6 Similarly, children aged below 5 years are at high risk of influenza-related complications, which may result in severe illness, hospitalization, and death.…”

Section: Introductionmentioning

confidence: 99%

Encouraging Influenza Vaccination Among Text4baby Pregnant Women and Mothers

Jordan

Bushar

Kendrick³

et al. 2015

American Journal of Preventive Medicine

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“…In addition to maternal complications, including hospitalization, cardiorespiratory complications, and death, maternal influenza infection is associated with increased incidence of spontaneous abortion, fetal death, preterm birth, and low-birthweight infants ( 4 ). Consequently, the Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practice recommends vaccination with inactivated influenza virus for all women who will be pregnant or postpartum during influenza season.…”

mentioning

confidence: 99%