Prevention and Control Strategies to Counter Dengue Virus Infection

Abstract

Dengue is currently the highest and rapidly spreading vector-borne viral disease, which can lead to mortality in its severe form. The globally endemic dengue poses as a public health and economic challenge that has been attempted to suppress though application of various prevention and control techniques. Therefore, broad spectrum techniques, that are efficient, cost-effective, and environmentally sustainable, are proposed and practiced in dengue-endemic regions. The development of vaccines and immunotherapies have introduced a new dimension for effective dengue control and prevention. Thus, the present study focuses on the preventive and control strategies that are currently employed to counter dengue. While traditional control strategies bring temporary sustainability alone, implementation of novel biotechnological interventions, such as sterile insect technique, paratransgenesis, and production of genetically modified vectors, has improved the efficacy of the traditional strategies. Although a large-scale vector control strategy can be limited, innovative vaccine candidates have provided evidence for promising dengue prevention measures. The use of tetravalent dengue vaccine (CYD-TDV) has been the most effective so far in treating dengue infections. Nonetheless, challenges and limitation hinder the progress of developing integrated intervention methods and vaccines; while the improvement in the latest techniques and vaccine formulation continues, one can hope for a future without the threat of dengue virus.

Dengue viruses circulating in Indonesia: A systematic review and phylogenetic analysis of data from five decades

“…Multiple traditional measures and strategies have been employed for dengue prevention and control, but most of these are compliance‐ and community involvement–dependent strategies which are hindered by poor compliance and absence of active local community involvement . Modern, integrated vector management approaches using novel biological control approaches such as paratransgenesis, sterile insect techniques, and production of genetically modified vectors, are urgently needed as well as innovative vaccine candidates. Our data presented in this study may be important for dengue vaccine development, particularly with regard to future vaccine composition.…”

Flavonoids as efficient scaffolds: Recent trends for malaria, leishmaniasis, Chagas disease, and dengue

“…However, during the febrile phase, liberal oral fluid administration and antipyretic treatment with paracetamol as required is recommended (WHO, ; WHO, ). At present, the main method to control or prevent the transmission of DENV is to combat vector mosquitoes by covering, emptying, and cleaning domestic water storage containers on a weekly basis, applying appropriate insecticides to water storage outdoor containers, and using personal household protection such as window screens, long‐sleeved clothes, insecticide‐treated materials, coils, and vaporizers (Rather et al, ; WHO, ).…”

Small-scale field assessment of efficacy of the autodissemination approach against Aedes sp. in an urban area

“…The immature larvae of these species can be found in a such as tires, artificial containers, can, bamboo stumps, and leaves. Among the control measures implemented against these species are through biological strategies (larvivorous fish and copepods), social mobilization, and chemicals [6]. Chemicals used in larvicide and adulticide target different life stages of mosquitoes.…”