Prevention and control of neglected tropical diseases: overview of randomized trials, systematic reviews and meta-analyses

Kappagoda, Shanthi; Ioannidis, John P. A.

doi:10.2471/blt.13.129601

Cited by 32 publications

(24 citation statements)

References 55 publications

(45 reference statements)

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“…The estimated 1 billion of the world's poorest population is affected by NTDs that comprise parasitic, bacterial and viral agents causing 534,000 deaths per year [24]. The NTDs are highly endemic in rural regions and in low-income countries with an average income less than US$2 a day.…”

Section: Strategies For Mitigationmentioning

confidence: 99%

Introductory Chapter: Neglected Tropical Waterborne Infectious Diseases - Strategies for Mitigation

Saxena¹,

Kumar²,

Haikerwal³

et al. 2018

Water Challenges of an Urbanizing World

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Section: Strategies For Mitigationmentioning

confidence: 99%

Introductory Chapter: Neglected Tropical Waterborne Infectious Diseases - Strategies for Mitigation

Saxena¹,

Kumar²,

Haikerwal³

et al. 2018

Water Challenges of an Urbanizing World

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“…So far NTDs had received miniscule treatment and research funding compared to better‐known infections such as HIV/AIDS, tuberculosis and malaria. According to WHO, NTDs affect more than one billion of the world’s poorest people each year, causing an estimated 534 000 deaths, mainly in socioeconomically disadvantaged areas with tropical and subtropical climates . One of these conditions is Chagas disease (CD): a protozoan infection produced by Trypanosoma cruzi , which in 80% of cases is transmitted by triatomine insects, with other transmission routes being oral, blood‐borne, vertical, via organ transplantation and as a result of laboratory accidents.…”

Section: Introductionmentioning

confidence: 99%

Infection by Strongyloides stercoralis in immigrants with Chagas disease: evaluation of eosinophilia as screening method in primary care

Dopico¹,

Rando‐Matos²,

Solsona³

et al. 2020

Tropical Med Int Health

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objectives To evaluate co-infection of Strongyloides stercoralis and Trypanosoma cruzi and to assess eosinophilia as a screening test for the detection of S. stercoralis infection in patients with Chagas disease (CD).methods A retrospective diagnostic validation study was performed on serum samples from primary care patients diagnosed with CD in the southern Barcelona metropolitan area. All samples with eosinophilia (n = 87) and a random sample of non-eosinophilic sera (n = 180) were selected. Diagnosis of CD was based on positive serology by means of two tests: ORTHOâ T. cruzi ELISA test, and BIO-FLASHâ Chagas or Bioelisa CHAGAS. SCIMEDX ELISA STRONGY-96 was used to diagnose strongyloidiasis.results Strongyloides stercoralis serology was positive in 15% of patients of whom 95% showed eosinophilia, vs. 21% of those with negative serology (P < 0.001), with differences in the mean eosinophil count (0.49 vs. 0.27 9 10 9 /l). Only 1.1% of patients with CD but without eosinophilia presented positive serology for S. stercoralis, whereas 44% of patients with CD and eosinophilia did (P < 0.001). Sensitivity and specificity values for eosinophilia were thus 95% and 79%, respectively. PPV was 42.5% and NPV, 98.9%.conclusions The prevalence of co-infection by T. cruzi and S. stercoralis is not negligible and has probably been underestimated for years in many areas, due to frequently subclinical infections. Therefore, serology seems mandatory for these patients and the use of eosinophilia as initial screening could facilitate the task, decreasing the number of analyses to be performed.Sustainable Development Goals (SDGs): SDG 3 (good health and well-being), SDG 9 (industry, innovation and infrastructure), SDG 17 (partnerships for the goals)

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“…Asimismo, son una causa importante de morbimortalidad, pues afectan a más de mil millones de personas, generan 534 000 muertes y representaron en 2010 el 1 % de la carga mundial de Años de Vida Ajustados por Discapacidad (AVAD), sin contar la malaria (5,6). Se ha demostrado el incremento de la susceptibilidad al tracoma y el empeoramiento de su curso en personas infectadas con VIH, tuberculosis o malaria, lo que evidencia un vínculo notable entre el tracoma y otras enfermedades (7).…”

Section: Introductionunclassified

Tracoma: de lo básico a lo clínico

Carvajal-Fernández

Villegas-Mesa

Quintero-Gutiérrez

et al. 2017

iatreia

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RESUMENEl tracoma es una de las Enfermedades Tropicales Desatendidas; lo producen los serotipos A, B, Ba y C de la bacteria intracelular Chlamydia trachomatis, adquirida a partir de la diseminación directa por contacto ocular, propagación indirecta por fómites, transmisión por moscas que buscan los ojos y contacto con los dedos contaminados con secreciones oculares y nasales. En la actualidad es la principal causa de ceguera prevenible en el mundo, representa el 1,4 % de los casos totales y genera el deterioro visual de 1,8 millones de personas, de las cuales 500 000 tienen ceguera. Se calcula que hay 51 países endémicos distribuidos en África, Asia, Latinoamérica y Oceanía. En América hay focos activos en Brasil, México, Guatemala y Colombia. Las manifestaciones oculares iniciales son epífora, inyección conjuntival y secreción mucopurulenta; con el curso crónico se producen queratitis, entropión, triquiasis y opacidades corneales. El diagnóstico es básicamente clínico. Para eliminar esta enfermedad, la Organización Mundial de la Salud formuló el Programa Global para la Eliminación del Tracoma para 2020, basado en la implementación de la estrategia SAFE, consistente en cirugía para evitar complicaciones, tratamiento antibiótico, higiene facial y corporal y mejoramiento de las condiciones ambientales.

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Prevention and control of neglected tropical diseases: overview of randomized trials, systematic reviews and meta-analyses

Cited by 32 publications

References 55 publications

Introductory Chapter: Neglected Tropical Waterborne Infectious Diseases - Strategies for Mitigation

Introductory Chapter: Neglected Tropical Waterborne Infectious Diseases - Strategies for Mitigation

Infection by Strongyloides stercoralis in immigrants with Chagas disease: evaluation of eosinophilia as screening method in primary care

Tracoma: de lo básico a lo clínico

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