Prevention and Control of Cardiovascular Diseases: What Works?

Gaiță, Dan; Sperling, Laurence

doi:10.1007/978-3-319-22357-5_19

Cited by 1 publication

(1 citation statement)

References 33 publications

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“…The clinical therapies and preventive measures for CVDs have become one of the highest expenditures in health care systems around the world in the efforts to combat all forms of NCDs (Laslett, et al, 2012). However, the incidence and mortality of CVDs continue to rise rapidly worldwide, and even the treatment strategies toward managing traditional risk factors, such as lipid levels and blood pressure, show significant beneficial effects in the secondary prevention of CVDs (Gaita & Sperling, 2015). CVD risk factors, such as hypertension, hyperglycemia, Type II diabetes, dyslipidemia, atherosclerosis, and metabolic syndrome, are now more prevalent in adults and even in adolescents into the 21st century (Alvarez, Vieira, Sichieri, & Veiga, 2011;Eisenmann, 2003).…”

Section: A C C E P T E Dmentioning

confidence: 99%

Prenatal inflammation exposure-programmed cardiovascular diseases and potential prevention

Deng

Song

Nie

et al. 2018

Pharmacology & Therapeutics

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In recent years, the rapid development of medical and pharmacological interventions has led to a steady decline in certain noncommunicable chronic diseases (NCDs), such as cancer. However, the overall incidence of cardiovascular diseases (CVDs) has not seemed to decline. CVDs have become even more prevalent in many countries and represent a global health threat and financial burden. An increasing number of epidemiological and experimental studies have demonstrated that maternal insults not only can result in birth defects but also can cause developmental functional defects that contribute to adult NCDs. In the current review, we provide an overview of evidence from both epidemiological investigations and experimental animal studies supporting the concept of developmental reprogramming of adult CVDs in offspring that have experienced prenatal inflammation exposure (PIE) during fetal development (PIE-programmed CVDs), a disease-causing event that has not been effectively controlled. This review describes the epidemiological observations, data from animal models, and related mechanisms for the pathogenesis of PIE-programmed CVDs. In addition, the potential therapeutic interventions of PIE-programmed CVDs are discussed. Finally, we also deliberate the need for future mechanistic studies and biomarker screenings in this important field, which creates a great opportunity to combat the global increase in CVDs by managing the adverse effects of inflammation for prepregnant and pregnant individuals who are at risk for PIE-programmed CVDs.

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