Prevention and control effects of edible fungi and their active ingredients on obesity: An updated review of research and mechanism

Wang, Guoze; Wang, Yi; Wang, Binbin; Su, Min; Shi, Zhongchao; Luo, Peng; Chen, Lei

doi:10.1016/j.jff.2023.105621

Cited by 7 publications

(2 citation statements)

References 100 publications

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“…As a critical prebiotic fungus in FBT, E. cristatum exhibited significant potential in restoring gut microbiota disorders and exerting anti-obesity effects [8]. Previous studies have indicated that several edible fungi can enhance energy expenditure by increasing lipid β-oxidation and promoting glucose metabolism [46,47]. However, there was no existing literature that described the fat-thermogenic effects of E. cristatum.…”

Section: Discussionmentioning

confidence: 99%

Eurotium cristatum from Fu Brick Tea Promotes Adipose Thermogenesis by Boosting Colonic Akkermansia muciniphila in High-Fat-Fed Obese Mice

Wang,

Li,

Yang

et al. 2023

Foods

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This study investigated the potential fat-thermogenic effects of Eurotium cristatum, and elucidated the underlying mechanisms. The 12-week administration of E. cristatum in HFD-fed obese mice reduced body weight and improved glucolipid metabolism disorders. The administration of E. cristatum also efficiently promoted thermogenesis by increasing the expression of UCP1 and PRDM16 in both interscapular brown adipose tissue (iBAT) and inguinal white adipose tissue (iWAT) of HFD-fed mice. Furthermore, E. cristatum shaped the gut microbiome by increasing the abundance of Parabacteroides and Akkermansia muciniphila, and also elevated the levels of cecal short-chain fatty acids, particularly propionate and acetate. Of note, A. muciniphila was highly negatively correlated with body weight gain (r = −0.801, p < 0.05) and the iWAT index (r = −0.977, p < 0.01), suggesting that A. muciniphila may play an important role in the thermogenic mobilization induced by E. cristatum. Continuous supplementation with A. muciniphila suppressed adipose accumulation, improved glucolipid metabolism, and enhanced the thermogenic activity of iWAT and iBAT. Collectively, our results propose that boosted A. muciniphila acts as a key microbe in tea-derived probiotic E. cristatum-mediated fat-thermogenic and anti-obesity effects.

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Section: Discussionmentioning

confidence: 99%

Eurotium cristatum from Fu Brick Tea Promotes Adipose Thermogenesis by Boosting Colonic Akkermansia muciniphila in High-Fat-Fed Obese Mice

Wang,

Li,

Yang

et al. 2023

Foods

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“…Edible herbs, also known as “food-medicine dual-use” foods, possess both dietary properties and pharmacological functions. According to traditional Chinese medicine (TCM) principles, specific combinations of medicinal foods can have synergistic effects [ 10 , 11 ]. Crataegus pinnatifida (CP), known as Shan Zha or hawthorn, is a popular functional food in China.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

Yuan,

Hu,

Yang

et al. 2024

Foods

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Obesity is a multifactorial chronic metabolic disease with multiple complications. Crataegus pinnatifida (CP) and Wolfiporia extensa (WE) are traditional functional foods with improving metabolic health properties. This study demonstrated the effect of CP and WE combination on ameliorating obesity induced by a high-fat diet (HFD). Moreover, the CP-WE food pair ameliorated HFD-induced metabolic disorders, including glucose intolerance, insulin resistance, hyperlipidemia, and hepatic steatosis. 16S rRNA gene amplicon sequencing and analysis revealed that CP combined with WE reshaped the composition of gut microbiota in HFD-fed mice. Furthermore, correlation analysis revealed a substantial association between the obesity-related parameters and the shifts in predominant bacterial genera influenced by the food pair intervention. In conclusion, this study demonstrated that the CP-WE food pair ameliorated HFD-induced obesity and reshaped gut microbiota composition, providing a promising approach to combat obesity through specific food combinations.

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Biological transformation of medicine and food homology hawthorn with Monascus ruber to enhance lipid-lowering function

Dong,

Cai,

Liao

et al. 2024

Food Bioscience

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Prevention and control effects of edible fungi and their active ingredients on obesity: An updated review of research and mechanism

Cited by 7 publications

References 100 publications

Eurotium cristatum from Fu Brick Tea Promotes Adipose Thermogenesis by Boosting Colonic Akkermansia muciniphila in High-Fat-Fed Obese Mice

Eurotium cristatum from Fu Brick Tea Promotes Adipose Thermogenesis by Boosting Colonic Akkermansia muciniphila in High-Fat-Fed Obese Mice

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

Biological transformation of medicine and food homology hawthorn with Monascus ruber to enhance lipid-lowering function

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