Prevention and Control Are Not a Regional Matter: A Spatial Correlation and Molecular Linkage Analysis Based on Newly Reported HIV/AIDS Patients in 2021 in Jiangsu, China

Yuan, Defu; Liu, Shanshan; Ouyang, Fei; Ai, Wei; Shi, Lingen; Liu, Xiaoyan; Qiu, Tao; Zhou, Ying; Wang, Bei

doi:10.3390/v15102053

Cited by 5 publications

(1 citation statement)

References 19 publications

(19 reference statements)

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“…Currently, the country has reached 86%, 76% and 71% of these targets, respectively, indicating substantial advancements in the HIV/AIDS response. 9 The establishment of targets in China both focuses on the epidemiological characteristics of AIDS and also aims to provide comprehensive care and protection for the individual health of patients with HIV/AIDS. Improving the health-related quality of life (HRQOL) of HIV-infected individuals has become a key objective of HIV prevention and control efforts for the future.…”

Section: Open Accessmentioning

confidence: 99%

Real experience of caregivers of patients with HIV/AIDS from the perspective of iceberg theory: a qualitative research

Tang,

Ren,

Wang

et al. 2024

BMJ Open

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ObjectiveThis study aimed to investigate the caregiving behaviours and supportive needs of caregivers of patients with HIV/AIDS and provide a basis for healthcare institutions to carry out caregiver interventions.DesignA purposive sampling method was used to select 11 caregivers of patients with HIV/AIDS in the Infectious Disease Department of a tertiary hospital in Nanjing, China, to conduct semistructured interviews. Colaizzi analysis was used to collate and analyse the interview data.SettingAll interviews were conducted at a tertiary hospital specialising in infectious diseases in Nanjing, Jiangsu Province.ParticipantsWe purposively sampled 11 caregivers of people with HIV/AIDS, including nine women and two men.ResultsAnalysing the results from the perspective of iceberg theory, three thematic layers were identified: behavioural, value and belief. The behavioural layer includes a lack of awareness of the disease, physical and mental coping disorders, and an increased sense of stigma; the values layer includes a heightened sense of responsibility, the constraints of traditional gender norms, the influence of strong family values and the oppression of public opinion and morality and the belief layer includes the faith of standing together through storms and stress.ConclusionHealthcare professionals should value the experiences of caregivers of patients with HIV/AIDS and provide professional support to improve their quality of life.

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Section: Open Accessmentioning

confidence: 99%

Real experience of caregivers of patients with HIV/AIDS from the perspective of iceberg theory: a qualitative research

Tang,

Ren,

Wang

et al. 2024

BMJ Open

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HIV Services Uptake Among People Living with HIV in Jiangsu Province, China: A Cross-Sectional Study

Ai,

Shi,

Tan

et al. 2024

AIDS Behav

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Combining molecular transmission network analysis and spatial epidemiology to reveal HIV-1 transmission pattern among the older people in Nanjing, China

Xu,

Jiang,

Jiang

et al. 2024

Virol J

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Background In China, the problem of HIV infection among the older people has become increasingly prominent. This study aimed to analyze the pattern and influencing factors of HIV transmission based on a genomic and spatial epidemiological analysis among this population. Methods A total of 432 older people who were aged ≥ 50 years, newly diagnosed with HIV-1 between January 2018 and December 2021 and without a history of ART were enrolled. HIV-1 pol gene sequence was obtained by viral RNA extraction and nested PCR. The molecular transmission network was constructed using HIV-TRACE and the spatial distribution analyses were performed in ArcGIS. The multivariate logistic regression analysis was performed to analyze the factors associated with clustering. Results A total of 382 sequences were successfully sequenced, of which CRF07_BC (52.3%), CRF01_AE (32.5%), and CRF08_BC (6.8%) were the main HIV-1 strains. A total of 176 sequences entered the molecular network, with a clustering rate of 46.1%. Impressively, the clustering rate among older people infected through commercial heterosexual contact was as high as 61.7% and three female sex workers (FSWs) were observed in the network. The individuals who were aged ≥ 60 years and transmitted the virus by commercial heterosexual contact had a higher clustering rate, while those who were retirees or engaged other occupations and with higher education degree were less likely to cluster. There was a positive spatial correlation of clustering rate (Global Moran I = 0.206, P < 0.001) at the town level and the highly aggregated regions were mainly distributed in rural area. We determined three large clusters which mainly spread in the intra-region of certain towns in rural areas. Notably, 54.5% of cases in large clusters were transmitted through commercial heterosexual contact. Conclusions Our joint analysis of molecular and spatial epidemiology effectively revealed the spatial aggregation of HIV transmission and highlighted that towns of high aggregation were mainly located in rural area. Also, we found vital role of commercial heterosexual contact in HIV transmission among older people. Therefore, health resources should be directed towards highly aggregated rural areas and prevention strategy should take critical persons as entry points. Supplementary Information The online version contains supplementary material available at 10.1186/s12985-024-02493-w.

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Prevention and Control Are Not a Regional Matter: A Spatial Correlation and Molecular Linkage Analysis Based on Newly Reported HIV/AIDS Patients in 2021 in Jiangsu, China

Cited by 5 publications

References 19 publications

Real experience of caregivers of patients with HIV/AIDS from the perspective of iceberg theory: a qualitative research

Real experience of caregivers of patients with HIV/AIDS from the perspective of iceberg theory: a qualitative research

HIV Services Uptake Among People Living with HIV in Jiangsu Province, China: A Cross-Sectional Study

Combining molecular transmission network analysis and spatial epidemiology to reveal HIV-1 transmission pattern among the older people in Nanjing, China

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