Preventing viral infections with polymeric virus catchers: a novel nanotechnological approach to anti-viral therapy

Sankarakumar, Niranjani; Tong, Yen Wah

doi:10.1039/c3tb00009e

Cited by 33 publications

(13 citation statements)

References 32 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of this, MIPs generally have lower specificity and sensitivity than antibodies (Tothill, 2009). This is not to say that MIPs for viruses have not been successfully produced (Bolisay et al, 2007;Sankarakumar, 2013). Like antibodies, MIPs can be applied onto sensor systems (Ge et al, 2013;PauláGleeson, 2013), and MIP-based sensors are growing in interest to researchers because of their potential in bringing down the cost of sensors.…”

Section: Introductionmentioning

confidence: 96%

Comparative investigations for adenovirus recognition and quantification: Plastic or natural antibodies?

Altıntaş

Pocock

Thompson

et al. 2015

Biosensors and Bioelectronics

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 96%

Comparative investigations for adenovirus recognition and quantification: Plastic or natural antibodies?

Altıntaş

Pocock

Thompson

et al. 2015

Biosensors and Bioelectronics

View full text Add to dashboard Cite

“…Tong and Sankarakumar suggested the use of imprinted polymers. Accordingly, a one-stage mini-emulsion polymerization, as illustrated in Figure 17, could be used to entrap viruses instead of inhibiting their activity [150]. Notably, this method is virus-specific, depending on the imprinted polymer matching a specific virus.…”

Section: Escherichia Coli Bmentioning

confidence: 99%

Polymers in the Medical Antiviral Front-Line

2020

View full text Add to dashboard Cite

Antiviral polymers are part of a major campaign led by the scientific community in recent years. Facing this most demanding of campaigns, two main approaches have been undertaken by scientists. First, the classic approach involves the development of relatively small molecules having antiviral properties to serve as drugs. The other approach involves searching for polymers with antiviral properties to be used as prescription medications or viral spread prevention measures. This second approach took two distinct directions. The first, using polymers as antiviral drug-delivery systems, taking advantage of their biodegradable properties. The second, using polymers with antiviral properties for on-contact virus elimination, which will be the focus of this review. Anti-viral polymers are obtained by either the addition of small antiviral molecules (such as metal ions) to obtain ion-containing polymers with antiviral properties or the use of polymers composed of an organic backbone and electrically charged moieties like polyanions, such as carboxylate containing polymers, or polycations such as quaternary ammonium containing polymers. Other approaches include moieties hybridized by sulphates, carboxylic acids, or amines and/or combining repeating units with a similar chemical structure to common antiviral drugs. Furthermore, elevated temperatures appear to increase the anti-viral effect of ions and other functional moieties.

show abstract

“…The essential differences between bulk polymerization and emulsion polymerization methods are the much lower monomer/template usage in the latter case and the addition of surfactant/stabilizer for the emulsion polymerization. Sankarakumar and Tong employed miniemulsion polymerization to prepare virus‐imprinted NPs. In this technique, the viral template, which was not soluble in imprinting polymerization mixture, was covalently attached to support NPs, and molecular imprinting was further applied on the surface of NPs using methacrylate and acrylic acid as functional monomers and EGDMA as a hydrophobic cross‐linker.…”

Section: Molecular Imprinting Of Proteinsmentioning

confidence: 99%

Biomacromolecule template-based molecularly imprinted polymers with an emphasis on their synthesis strategies: a review

Zahedi

Ziaee

Abdouss

et al. 2016

Polym. Adv. Technol.

View full text Add to dashboard Cite

Molecular imprinting is an efficient tool for generating synthetic acceptors with specific recognition sites, which are mimed from template structures via polymerization. The final products of this strategy lead to high‐performance polymers with active recognition sites for a range of various applications in terms of extraction and separation, characterization and recognition, biomedicine, biosensors, and drug delivery. Molecular imprinting of biomacromolecules synthesizes a series of matrices that may be referred to as biomolecularly imprinted polymers (BMIPs). In this review article, an overview of different methods for fabricating BMIPs with an emphasis on novel polymerization schemes along with potential challenges is discussed. Additionally, selected applications of BMIPs will be briefly highlighted derived from the latest research papers. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

Preventing viral infections with polymeric virus catchers: a novel nanotechnological approach to anti-viral therapy

Cited by 33 publications

References 32 publications

Comparative investigations for adenovirus recognition and quantification: Plastic or natural antibodies?

Comparative investigations for adenovirus recognition and quantification: Plastic or natural antibodies?

Polymers in the Medical Antiviral Front-Line

Biomacromolecule template-based molecularly imprinted polymers with an emphasis on their synthesis strategies: a review

Contact Info

Product

Resources

About