Preventing taxane-related peripheral neuropathy, pain and nail toxicity: a prospective self-controlled trial comparing hilotherapy with frozen gloves in early breast cancer

Coolbrandt, Annemarie; Vancoille, K.; Dejaeger, Eddy; Peeters, H; Laenen, Annouschka; Neven, Patrick; Punie, Kevin; Wildiers, Hans

doi:10.1007/s10549-021-06477-0

Cited by 13 publications

(23 citation statements)

References 38 publications

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“…CIPN is acknowledged as a serious clinical problem wherefore international clinical practice guidelines on the prevention and treatment of CIPN have been developed [20][21][22]. There is however an overall lack of evidence supporting the use of preventive approaches for CIPN although cryotherapy seems promising [23]. Also, the evidence for efficacious treatment of established CIPN is limited, except for neuropathic pain [24].…”

Section: Discussionmentioning

confidence: 99%

Impact of persistent peripheral neuropathy on health-related quality of life among early-stage breast cancer survivors: a population-based cross-sectional study

Engvall

Gréen

Fredrikson

et al. 2022

Breast Cancer Res Treat

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Background We explored the impact of persistent sensory and motor taxane-induced peripheral neuropathy (TIPN) symptoms on health-related quality of life (HRQL) among early-stage breast cancer survivors (ESBCS). Methods A population-based cohort of 884 residual-free ESBCS received a postal questionnaire, including the EORTC chemotherapy-induced PN (CIPN20) and the EORTC QLQ-C30 instruments. Mean scores of QLQ-C30 scales among ESBCS with and without TIPN were calculated and adjusted for confounding factors (age, lifestyle factors, co-morbidities; linear regression analyses). Interpretation of QLQ-C30 results were based on guidelines. Results Response rate was 79%, and 646 survivors were included in the analysis. In median, 3.6 (1.5–7.3) years had elapsed post-taxane treatment. All TIPN symptoms had a significant impact on global QoL, which worsened with increased severity of TIPN. Between 29.5% and 93.3% of ESBCS with moderate-severe TIPN reported a clinical important impairment of functioning and personal finances, 64.3–85.7% reporting “difficulty walking because of foot drop,” and 53.1–81.3% reporting “problems standing/walking because of difficulty feeling ground under feet” had impaired functioning/finances. The difference in mean scores between affected and non-affected survivors was highest for “numbness in toes/feet” and “difficulty walking because of foot drop.” Moderate-severe “difficulty climbing stairs or getting out of chair because of weakness of legs” and “problems standing/walking because of difficulty feeling ground under feet” were associated with the largest clinically important differences on all scales. Conclusion Persistent sensory and motor TIPN is associated with clinically relevant impairment of global QoL, functioning, and personal finances among ESBCS, which increased with level of TIPN severity.

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Section: Discussionmentioning

confidence: 99%

Impact of persistent peripheral neuropathy on health-related quality of life among early-stage breast cancer survivors: a population-based cross-sectional study

Engvall

Gréen

Fredrikson

et al. 2022

Breast Cancer Res Treat

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“…Most of the articles studied were published in the last 3 years ( n = 9) [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. Six documents were published in the United States [ 18 , 25 , 26 , 27 , 28 , 29 ], and two were published in Turkey [ 17 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

Wellbeing and Complementary Therapies in Breast Cancer Peripheral Neuropathy Care: A Scoping Review Focused on Foot Health

Veiga-Seijo

Perez-Lopez

Fernandez-Lopez

et al. 2023

Cancers

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Background: Chemotherapy-induced peripheral neuropathy is a multidimensional health problem. Up to now, little evidence has been found concerning its impact on quality of life and foot health. Evaluation tools and prevention and treatment strategies must be reported. This study aimed to map the literature on the impact of this side effect on the wellbeing and foot health of people with breast cancer and to describe their main assessment strategies and complementary therapies. Methods: A scoping review was carried out while following the PRISMA-ScR and Arksey and O’Malley guidelines. Different databases (Cochrane Plus, Scopus, Web of Science, and Pubmed) were used. A total of 221 results were identified. Sixteen articles were included. Results: The thematic analysis obtained the following categories: the impact of peripheral neuropathy on quality of life and foot health, complementary therapies as a path for new strategies, and the need for clinicians and researchers to get involved in researching this side effect. Conclusions: Peripheral neuropathy has a negative impact on people’s quality of life. Implications for foot health and maintaining an active and healthy lifestyle have not been previously reported. Complementary therapies are recommended by scientific evidence, highlighting exercise. However, there is a need to develop more research that will help to incorporate them into evidence-based practice.

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“…In the case of breast cancer, taxane chemotherapy stands out because it plays a fundamental role in its treatment and produces side effects that affect body organs in which the foot is involved. Thus, this study particularly emphasizes foot health since previous research highlighted dermatological and neuropathic side effects [16], such as nail toxicities (40%) [17], hand-foot syndrome [18] or peripheral neuropathy (58.4%) [17,19]. In fact, it has been highlighted the importance of extremities' effects on the quality of life in this population [17].…”

Section: Introductionmentioning

confidence: 86%

“…In addition to the above, it is essential to identify and manage skin problems not only so that the quality of life of people with cancer is ensured [17] but also so that modi cations in treatment doses are minimal, as indicated by scienti c evidence [16]. The present study reveals that of the people who had their treatment dose suspended or reduced, 36.2% was due to problems with their feet, which indicates that this aspect is not yet assured.…”

Section: Structural Skin Nail Conditions and Peripheral Neuropathymentioning

confidence: 99%

“…Thus, this study particularly emphasizes foot health since previous research highlighted dermatological and neuropathic side effects [16], such as nail toxicities (40%) [17], hand-foot syndrome [18] or peripheral neuropathy (58.4%) [17,19]. In fact, it has been highlighted the importance of extremities' effects on the quality of life in this population [17]. Nevertheless, little is known about how these therapies impact people's foot health and, consequently, their quality of life.…”

Section: Introductionmentioning

confidence: 97%

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Foot health and quality of life in women with breast cancer undergoing chemotherapy: a cross-sectional study. Working towards a holistic care approach.

Veiga-Seijo

Pértega-Díaz

Perez-Lopez

et al. 2023

Preprint

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Background. Chemotherapy is one of the most widely used therapies for breast cancer, triggering important repercussions on people’s quality of life. However, little research has been undertaken about podiatric adverse effects. This study aimed was to determine the prevalence of podiatric pathology developed in people with breast cancer who receive chemotherapy. Methods. Observational, descriptive, and cross-sectional study was conducted in the Oncology service of the A Coruña University Hospital (northwest Spain). People with breast cancer and undergoing chemotherapy treatment of legal age (≥18), who signed the informed consent (n=117) were included. Sociodemographic, comorbidity, disease and foot health variables, as well as two self-administered questionnaires (Foot Health Status Questionnaire and Foot Function Index) were studied. The current ethical-legal aspects were followed. Results. Foot health problems were highly prevalent, highlighting nail color changes (60.3%), onychocryptosis (39.7%), xerosis (62.1%), plantar fasciitis (12.9%), and neuropathic symptoms (75.2%). Some foot pain was presented in 77.8% of the sample, predominantly at nail level (15.4%) or sole of the foot and nail (14.5%). Most participants described their foot health as fair or poor (56.4%) and felt limited in walking (65.8%). The lowest score for the Foot Health Status Questionnaire was footwear (32.5±42.1). Conclusions. Foot health adverse effects represent worrisome problems in women with breast cancer undergoing chemotherapy, due to their high prevalence and negative implications on quality of life. These problems are critical as they may have implications for stopping or reducing chemotherapy. All these results call for the development of more research to contribute to the care and wellbeing of people with cancer who receive treatments such as chemotherapy. Thus, this line of research is a new path to be developed by the podiatry community.

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Preventing taxane-related peripheral neuropathy, pain and nail toxicity: a prospective self-controlled trial comparing hilotherapy with frozen gloves in early breast cancer

Cited by 13 publications

References 38 publications

Impact of persistent peripheral neuropathy on health-related quality of life among early-stage breast cancer survivors: a population-based cross-sectional study

Impact of persistent peripheral neuropathy on health-related quality of life among early-stage breast cancer survivors: a population-based cross-sectional study

Wellbeing and Complementary Therapies in Breast Cancer Peripheral Neuropathy Care: A Scoping Review Focused on Foot Health

Foot health and quality of life in women with breast cancer undergoing chemotherapy: a cross-sectional study. Working towards a holistic care approach.

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