Preventing pregnancy-induced hypertension: the role of calcium and magnesium

Kisters, Klaus; Gremmler, B.; Hausberg, Martin

doi:10.1097/01.hjh.0000194113.04604.31

Cited by 9 publications

(8 citation statements)

References 6 publications

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“…Mechanisms underlying the association between calcium, magnesium, vitamin C and b-carotene deficiency and increased risk of cesarean section remain largely obscure. Several studies have shown that magnesium, 33 vitamin C 34 and b-carotene 35 supplementation can decrease adverse obstetric outcomes and reduce risk of cesarean section. 36 In addition, higher rate of cesarean section in the control group in our study might be attributed to maternal hypertension at the end pregnancy.…”

Section: Discussionmentioning

confidence: 99%

The effect of DASH diet on pregnancy outcomes in gestational diabetes: a randomized controlled clinical trial

et al. 2014

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Section: Discussionmentioning

confidence: 99%

The effect of DASH diet on pregnancy outcomes in gestational diabetes: a randomized controlled clinical trial

et al. 2014

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“…Although evidence suggests a relationship between Ca 2+ intake and decreased incidence of hypertension, the protective mechanism is unclear. It has also been observed that patients with PE have decreased plasma concentrations of Ca 2+ ; however, recently, a study has shown that membrane Ca 2+ content is significantly increased despite the low plasma concentrations, suggesting altered membrane ion transport during PE [11]. Magnesium is one of the essential minerals needed by humans in relatively large amounts.…”

Section: Calcium Magnesium and Potassiummentioning

confidence: 99%

Interactions of Biologically Active Factors and Vascular Mediators During Hypertension in Pregnancy

Stennett¹,

Khalil²

2007

CHYR

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Normal pregnancy is associated with changes in the cardiovascular system, including vascular remodeling of the uterine and systemic circulation in order to meet the metabolic demands of the developing fetus. These cardiovascular changes are due to alterations in the amount/activity of vascular mediators such as nitric oxide, prostacyclin and endothelin in the endothelium; calcium and protein kinase C in the smooth muscle; and metalloproteases in the extracellular matrix. Hypertension in pregnancy is a major complication, and can lead to life threatening neurovascular disorders. It has been suggested that hypertension in pregnancy may develop from an inadequate invasion of cytotrophoblasts into the uterine artery, causing reduction in the uteroplacental perfusion pressure, and resulting in placental ischemia/hypoxia. This placental hypoxic state is thought to induce the release of various biologically active factors such as cytokines, reactive oxygen species, and hypoxia-inducible factors. Elevated plasma/tissue levels of these factors during pregnancy could cause vascular dysfunction, vasoconstriction and hypertension. The purpose of this review is to discuss the interactions between biologically active circulating factors and vascular mediators, released during preeclampsia as compared to those released in other conditions characterized by hypoxia, in order to provide insight into the sequence of events that leads to the development of hypertension in pregnancy.

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“…In this context changes in magnesium metabolism have been implicated in the pathogenesis of hypertension [9,10,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,36] Therefore it was of interest to study magnesium deficient patients with essential hypertension concerning CIMT.…”

Section: Introductionmentioning

confidence: 99%

Magnesium metabolism and cardiovascular diseases

Kisters¹,

Al-Tayar²,

Nguyen³

et al. 2011

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A magnesium defieieney is known to be involved in the pathogenesis of primary hypertension. In patients with essential hypertension intima media thickness is increased in about 70% (ELSA Study), In our study, we investigated 21 patients ( 10 female, 11 male, average age 56.3 ± 6,6 years) with untreated essential hypertension (Grades I and II according to WHO guidelines). All patients had a hypomagnesemia in serum (1,57 ±0.11 mg%). In all patients we found a significant increase in intima media thickness of arteria carotis communis (0,97 ± 0,08 mm) (r =-0.869, p< 0.0001). The results show that a magnesium defieieney in' patients with essential hypertension may be of speeial pathogenetie importance. In addition, the role of magnesium deficiency in the development of arteriosclerosis has to be diseussed. Furthermore, we demonstrated a eonnection between magnesium defieieney and an inereased intima media thickness. In this context, calcium antagonist therapy or magnesium supplementation may be of' advantage when treating intima media thickness in hypertension.

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Preventing pregnancy-induced hypertension: the role of calcium and magnesium

Cited by 9 publications

References 6 publications

The effect of DASH diet on pregnancy outcomes in gestational diabetes: a randomized controlled clinical trial

The effect of DASH diet on pregnancy outcomes in gestational diabetes: a randomized controlled clinical trial

Interactions of Biologically Active Factors and Vascular Mediators During Hypertension in Pregnancy

Magnesium metabolism and cardiovascular diseases

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