Preventing organ-specific chemotherapy toxicity

The Prevalance of Sensori-Neural Hearing Loss and Ototoxicity in Acute Myeloid Leukemia Patients

“…Specific ototoxicity of the chemotherapeutics used in AML has not been described and hearing loss after treatment for AML is likely related to the frequent use of aminoglycosides during neutropenic sepsis [5].…”

“…Anthracyclines present a risk of both early and late cardiotoxicity owing to selective toxicity of myocardial tissue, with a progressive dosedependent dilated cardiomyopathy that irreversibly evolves toward congestive heart failure [4,5].…”

Procedures for fertility preservation in female cancer patients

“…cryopreservation of embryos) are well established, while other procedures, like cryopreservation and later transplantation of oocytes and ovarian tissue are still in an experimental phase. Therefore, these latter procedures can be used only in controlled studies supervised by ethical committees, after careful evaluation of the potential risks and benefits [5][6]9]. A special evaluation is required by the fact that the risk of retransmission of tumor cells and consequently the risk of recurrence in association with transplantation of ovarian tissue is not completely known [1,[5][6][7][10][11].…”