Preventing Multidrug-Resistant Bacterial Transmission in the Intensive Care Unit with a Comprehensive Approach: A Policymaking Manual

Schinas, Georgios; Polyzou, Elena; Spernovasilis, Nikolaos; Gogos, Charalambos; Dimopoulos, George; Akinosoglou, Karolina

doi:10.3390/antibiotics12081255

Cited by 9 publications

(6 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MRSA infections present formidable challenges in clinical settings and communities due to their limited therapeutic options [ 56 ]. Addressing MRSA necessitates a comprehensive approach encompassing meticulous infection control strategies, vigilant surveillance, and the judicious use of alternative antibiotics [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Green synthesis of silver nanoparticle using pollen extract from Tetragonisca angustula a stingless bee

Santos,

Batista,

Cerqueira

et al. 2024

Discover Nano

View full text Add to dashboard Cite

This study explores the green synthesis of silver nanoparticles (AgNPs) using a methanolic extract of fermented pollen from Tetragonisca angustula, a species of stingless bees. The AgNPs exhibit spherical morphology, low charge values, and suspension stability, with their unique composition attributed to elements from the pollen extract. Antioxidant assays show comparable activity between the pollen extract and AgNPs, emphasizing the retention of antioxidant effects. The synthesized AgNPs demonstrate antimicrobial activity against multidrug-resistant bacteria, highlighting their potential in combating bacterial resistance. The AgNPs exhibit no toxic effects on Drosophila melanogaster and even enhance the hatching rate of eggs. The study underscores the innovative use of stingless bee pollen extract in green synthesis, offering insights into the varied applications of AgNPs in biomedicine.

show abstract

Section: Discussionmentioning

confidence: 99%

Green synthesis of silver nanoparticle using pollen extract from Tetragonisca angustula a stingless bee

Santos,

Batista,

Cerqueira

et al. 2024

Discover Nano

View full text Add to dashboard Cite

show abstract

“…Staying updated on research and innovations in infection control further enhances these measures. Regularly updating a tailored plan is essential for healthcare facilities [33] .…”

Section: Discussionmentioning

confidence: 99%

Environmental Metagenomic Analysis of "ESKAPE" Pathogens in the Pediatric Intensive Care Unit of General Hospital Yogyakarta Indonesia

Rizki,

Murni,

Aman

et al. 2024

Prog Micobes Mol Biol

View full text Add to dashboard Cite

Healthcare-associated infections (HAIs) are infections that occur while receiving health care, develop in a hospital or other healthcare facility, and first appear 48 hours or more after hospital admission, or within 30 days after having received health care. HAIs are linked to high mortality rates, prolonged stays, increased hospital overhead costs, and financial burdens on patients. Bacterial transmission from medical personnel or the environment, or patient-to-patient contact are all potential causes of these infections. A molecular epidemiology approach is needed to examine the contribution of risk factors and the distribution of "ESKAPE" pathogens within the hospital environment. In this study, we conducted a comprehensive analysis of the distribution of ESKAPE bacterial pathogens in the environment of pediatric intensive care units over a 30-day time interval using shotgun metagenomics. We collected samples from handwashing sinks, the floor around patients, and ventilator screens and tubes in the pediatric intensive care unit (PICU) of General Hospital, Yogyakarta, Indonesia in March 2022. We determine taxonomic profiles and also detect resistome, and virulome distribution of ESKAPE pathogens on various environmental surfaces through shotgun metagenomic sequencing. The microbiomes of the floor, sink, and mechanical ventilator exhibit a diverse composition of microbial communities, featuring significant species richness based on Shannon and Simpson’s index. These microbiomes encompass a wide array of microbial species, including ESKAPE bacterial pathogens, as well as profiles related to resistome and virulome. ESKAPE pathogens, especially Acinetobacter baumannii, predominated in the PICU environment. Most virulome have been associated with metabolism/nutrition and adhesion. Noteworthy findings include resistome genes characterized by mechanisms like efflux pumps (MDR) and alterations in antibiotic targets.

show abstract

“…The issue of CD contamination in hospitals can be effectively tackled through a comprehensive approach that includes multiple strategies. These strategies may include promoting the responsible use of antibiotics, implementing effective infection control practices, enhancing environmental cleaning, providing education and training on infection prevention, using probiotics, adopting early detection methods, and isolating affected patients [64].…”

Section: Discussionmentioning

confidence: 99%

A Real-World Study on the Clinical Characteristics, Outcomes, and Relationship between Antibiotic Exposure and Clostridioides difficile Infection

Vintila,

Arseniu,

Morgovan

et al. 2024

Antibiotics

View full text Add to dashboard Cite

Clostridioides difficile is a Gram-positive bacteria that causes nosocomial infections, significantly impacting public health. In the present study, we aimed to describe the clinical characteristics, outcomes, and relationship between antibiotic exposure and Clostridioides difficile infection (CDI) in patients based on reports from two databases. Thus, we conducted a retrospective study of patients diagnosed with CDI from Sibiu County Clinical Emergency Hospital (SCCEH), Romania, followed by a descriptive analysis based on spontaneous reports submitted to the EudraVigilance (EV) database. From 1 January to 31 December 2022, we included 111 hospitalized patients with CDI from SCCEH. Moreover, 249 individual case safety reports (ICSRs) from EVs were analyzed. According to the data collected from SCCEH, CDI was most frequently reported in patients aged 65–85 years (66.7%) and in females (55%). In total, 71.2% of all patients showed positive medical progress. Most cases were reported in the internal medicine (n = 30, 27%), general surgery (n = 26, 23.4%), and infectious disease (n = 22, 19.8%) departments. Patients were most frequently exposed to ceftriaxone (CFT) and meropenem (MER). Also, in the EV database, most CDI-related ADRs were reported for CFT, PIP/TAZ (piperacillin/tazobactam), MER, and CPX (ciprofloxacin). Understanding the association between previous antibiotic exposure and the risk of CDI may help update antibiotic stewardship protocols and reduce the incidence of CDI by lowering exposure to high-risk antibiotics.

show abstract

Preventing Multidrug-Resistant Bacterial Transmission in the Intensive Care Unit with a Comprehensive Approach: A Policymaking Manual

Cited by 9 publications

References 88 publications

Green synthesis of silver nanoparticle using pollen extract from Tetragonisca angustula a stingless bee

Green synthesis of silver nanoparticle using pollen extract from Tetragonisca angustula a stingless bee

Environmental Metagenomic Analysis of "ESKAPE" Pathogens in the Pediatric Intensive Care Unit of General Hospital Yogyakarta Indonesia

A Real-World Study on the Clinical Characteristics, Outcomes, and Relationship between Antibiotic Exposure and Clostridioides difficile Infection

Contact Info

Product

Resources

About