Preventing intraperitoneal adhesions with atorvastatin and sodium hyaluronate/carboxymethylcellulose: a comparative study in rats

Lalountas, Miltiadis; Ballas, Konstantinos; Skouras, Christos; Asteriou, Christos; Kontoulis, Theodoros M.; Pissas, Dimitrios; Triantafyllou, Apostolos; Sakantamis, Athanasios K.

doi:10.1016/j.amjsurg.2009.06.026

Cited by 39 publications

(43 citation statements)

References 25 publications

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“…In our study, it was used the effect of flunixin meglumine 1.1 mg/kg on the postoperative adhesions and HA/CMC covered on the peritoneal defect. These results, as expected under guidance of previous result of the studies [7,10,11,[14][15][16][17][18] , have supported that both HA/CMC and flunixin meglumine decreases adhesion formation, as evaluated by the scoring of adhesion, fibrosis, and inflammatory compared with the control group (P<0.05), (Table 1). …”

Section: Discussionsupporting

confidence: 87%

“…There are many experimental models for the development of inflammatory and postoperative adhesions including the local peritoneal model, the damaged uterine horn, introduction of foreign objects in the abdominal and pelvic cavity, the direct mechanical intestinal damage, the ileal transection, the thermal damage, the large bowel anastomosis, the bacterial contamination, and the scraping models [16,17,19,20,22] . In this study, the parietal peritoneal model was chosen due to the similarities of the physiopathology after abdominal surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Various studies have pointed out that the adhesionforming process and mesotheliozation are completed after 7 to 14 days following surgery [10,17,23,26] . Therefore, it was chosen to wait 10 days before performing relaparotomy because other studies had shown high adhesion scores at the period of this time [4,5,27] .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it was chosen to wait 10 days before performing relaparotomy because other studies had shown high adhesion scores at the period of this time [4,5,27] . There have many adhesion scoring systems described by researchers in experimental models [4][5][6]16,17,22] . Macroscopical and histopathological evaluations were made according to semiquantitative scoring systems that had been described by Mazuji et al [24] and Hooker et al [25] .…”

Section: Discussionmentioning

confidence: 99%

“…A current interest to overcome adhesions have been focused on various combination of drugs [2,4,8,9,[17][18][19][20][21][22][23] . Therefore, it was to investigate the effect of HA/CMC, flunixin meglumine and their combination on the prevention of postoperative intraabdominal adhesions in rabbits.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Hyaluronic Acid/Carboxymethylcellulose and Flunixin Meglumine Combination on the Prevention of Postoperative Intraabdominal Adhesions: An Experimental Study in Rabbits

Köm¹

2013

Kafkas Univ Vet Fak Derg

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Despite the development in the knowledge concerning pathophysiology of abdominal cavity and improvement in surgical techniques, intraabdominal adhesions are one of the most common complications in surgery. The aim of this study was to determine the effects of hyaluronic acid/carboxymethylcellulose (HA/CMC) and flunixin meglumine combination on the prevention of postoperative intraabdominal adhesions in rabbits. All the surgery were made under aseptic condition under general anesthesia. A 2x2 cm area of parietal peritoneum was resected on the abdominal wall after median laparotomy. Twenty-four adult, male rabbits were divided into four groups equally. Groups were evaluated as C (control), S (HA/CMC), F (flunixin meglumine), and SF (HA/CMC and flunixin meglumine combination). No medication was given to the rabbits in group C. In S and SF groups, 3x3 cm of HA/CMC applied directly to peritoneal defect. In F and SF groups, flunixin meglumine was administred 1.1 mg/kg for 5 days intraperitoneally. Relaparotomy was performed 10 days after surgery. As a result of macroscopical and histopathological evaluations, the scores of adhesion in the S, F, and SF groups were significantly lower than those of the control group (P<0.05). Adhesion scores in SF group were lower as compared to S and F groups (P<0.05). It is observed that HA/CMC and flunixin meglumine combination can be used more effective on the prevention of postoperative intraabdominal adhesions in rabbits.

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Section: Discussionsupporting

confidence: 87%