Preventing hair loss during adriamycin therapy

Lovejoy, Nancy C.

doi:10.1097/00002820-197904000-00005

Cited by 15 publications

(41 citation statements)

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“…Therefore, we excluded it from the final analysis. In addition, one article was added through manual search of the bibliographies of relevant articles, resulting in a total of 17 trials being included in the meta‐analysis and analyzed to calculate the RRs (Fig. ) , , …”

Section: Resultsmentioning

confidence: 99%

“…Table shows the general characteristics of the 17 trials included in the final analysis , , . Scalp cooling was investigated in 10 studies, , scalp compression in one study, a combination of cooling and compression in three studies and topical minoxidil in two studies . Panicum miliaceum was investigated once .…”

Section: Resultsmentioning

confidence: 99%

“…This method involves an inflatable tourniquet used to reduce the blood supply to the scalp during the time of peak plasma concentration of chemotherapeutics. It can be used alone or in combination with scalp cooling . However, these methods seems to be rarely used for prevention of CIA at the present time, and the method alone has not been studied clinically since 1978 …”

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confidence: 99%

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Efficacy of interventions for prevention of chemotherapy‐induced alopecia: A systematic review and meta‐analysis

Shin

Kim

et al. 2014

Intl Journal of Cancer

117

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Chemotherapy-induced alopecia (CIA) is a highly distressing event for cancer patients, and hence, we here aimed to assess the efficacy of various interventions in the prevention of CIA. We searched PubMed, EMBASE and the Cochrane Library, from June 20, 2013 through August 31, 2013. Two of the authors independently reviewed and selected clinical trials that reported the efficacy of any intervention for prevention of CIA compared with that of controls. Two authors extracted data independently on dichotomized outcome in terms of CIA occurrence. Relative risks (RRs) and 95% confidential intervals (CIs) were calculated for efficacy of CIA prevention by using random-effect or fixed-effect models. Out of 691 articles retrieved, a total of eight randomized controlled trials and nine controlled clinical trials involving 1,098 participants (616 interventions and 482 controls), were included in the final analyses. Scalp cooling, scalp compression, a combination of cooling and compression, topical minoxidil and Panicum miliaceum were used as interventions. The participants were mainly breast cancer patients receiving doxorubicin-or epirubicin-containing chemotherapy. Scalp cooling, which is the most popular preventive method, significantly reduced the risk of CIA (RR 5 0.38, 95% CI 5 0.32-0.45), whereas topical 2% minoxidil and other interventions did not significantly reduce the risk of CIA. No serious adverse effects associated with scalp cooling were reported. Our results suggest that scalp cooling can prevent CIA in patients receiving chemotherapy. However, the long-term safety of scalp cooling should be confirmed in further studies.Chemotherapy-induced alopecia (CIA) is a common and stressful adverse effect associated with chemotherapy. 1 CIA generally starts at 1-3 weeks after the first cycle of chemotherapy, and is aggravated after subsequent cycles. 2 Fortunately CIA is spontaneously recovered after 3-6 months in usual cases. 3 However, not a few patients suffer from permanent CIA, and many patients experience changes in hair color, texture and growth rate even after regrowth of hairs. 4 The occurrence and severity of CIA is dependent on the chemotherapeutic dose, administration schedule and other protocols. 5 Various cytotoxic chemotherapeutics can cause CIA. The chemotherapeutics target all rapidly proliferating cells, and consequently damage not only tumor cells but also the hair follicles. At any given time, approximately 90% of the hair follicles in the human scalp are in the anagen stage, and these hair matrix cells proliferate fast. The apoptosis of these cells caused by cytotoxic chemotherapeutics results in hair shedding, which is called anagen effluvium. 6 Although CIA is generally reversible 3-6 months postchemotherapy, it commonly causes psychosocial stress to the patients, including negative changes in body image, sexuality, self-esteem and disturbances in social relationships. The fear of hair loss and the associated distress may even result in cancer patients refusing proper chemotherapy treatment. 7 ...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Efficacy of interventions for prevention of chemotherapy‐induced alopecia: A systematic review and meta‐analysis

Shin

Kim

et al. 2014

Intl Journal of Cancer

117

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“…The recommendation was to maintain the compression at a level between 40 and 70 mm Hg above systolic blood pressure. This approach ensures maximum protection of hair follicles, as well as taking into account the possibility of pressure variation in a scope similar to pressure noted in patients in the perioperative period [7]. The method was typically used in patients without arterial hypertension or severe atheromatosis, with cancer types other than leukaemia and without brain metastases [7].…”

Section: Scalp Compressionmentioning

confidence: 99%

“…The scalp compression method was used in mono-and combination chemotherapy with cyclophosphamide, vin-cristine, methotrexate, doxorubicin and teniposide [7,[10][11][12]. Even though the method was demonstrated to have a moderately protective effect, it needs to be noted that the studies were performed in small groups of patients and, more importantly, some of them lacked random patient assignment or objective criteria for the assessment of severity of hair loss.…”

Section: Scalp Compressionmentioning

confidence: 99%

Hair loss as a consequence of cancer chemotherapy – physical methods of prevention. A review of the literature

Dąbrowski¹

2011

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Therapeutic Properties of Nardostachys jatamansi and Its Applications in Post-Chemotherapy-Induced Hair Loss in Cancer Patients

Azhagu Saravana Babu,

Vajiha Aafrin,

Goyali

et al. 2023

Bioprospecting of Tropical Medicinal Plants

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Preventing hair loss during adriamycin therapy

Cited by 15 publications

References 0 publications

Efficacy of interventions for prevention of chemotherapy‐induced alopecia: A systematic review and meta‐analysis

Efficacy of interventions for prevention of chemotherapy‐induced alopecia: A systematic review and meta‐analysis

Hair loss as a consequence of cancer chemotherapy – physical methods of prevention. A review of the literature

Therapeutic Properties of Nardostachys jatamansi and Its Applications in Post-Chemotherapy-Induced Hair Loss in Cancer Patients

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