Preventing endophthalmitis after cataract surgeries

A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitis

“…Gatifloxacin (GAT), a fourth-generation fluoroquinolone with good photostability, was chosen as the target drug in this study given its being a broad-spectrum antibiotic without a definite phototoxic effect [ 45 ]. It has showed efficient prevention and treatment on endophthalmitis [ 5 , 46 , 47 ] and its minimal inhibitory concentrations (MIC 90 ) against the most common cause of POE, staphylococcus epidermidis (S. epidermidis) [ 48 ], was 0.25–2 μg/mL [ 49 , 50 ]. GAT also shows great solubility and inert properties in some photosensitive chemicals, so it can be well distributed in the polymer matrix by adjusting the ingredients of the mixture for photocuring.…”