Preventing dyslipidemia by Chlorella pyrenoidosa in rats and hamsters after chronic high fat diet treatment

Cherng, Jong Yuh; Shih, Mei‐Fen

doi:10.1016/j.lfs.2004.10.055

Cited by 84 publications

(77 citation statements)

References 25 publications

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“…Numerous experimental reports showed that cholesterol and high dietary fat induce hypercholesterolemia in animal models. 37,38 Similar results were also observed with the high cholesterol diet animals have increase lipid status and increased lipid level act as indicator of establishment of hypercholesterolemia in animal models. HDL cholesterol is inversely connected with total cholesterol and several evidences are available regarding this fact.…”

Section: In Vitro Antioxidant Activity Of Vvme and Vvaesupporting

confidence: 72%

Antioxidant and Anti-Hypercholesterolemic Potential of Vitis vinifera Leaves

Devi¹,

Singh²

2017

Phcog J

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Background: Grapes (Vitis vinifera) are universally appreciated fruit for their delicacy, nutrition and accepted as functional food. The objective of the present study is to evaluate antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves extract. Methods: Qualitative and quantitative phytochemical screening of methanolic (VVME) and aqueous (VVAE) extract was carried out to identify the phytoconstituents. Antioxidant potential was evaluated by employing in-vitro and in vivo assays. The anti-hypercholesterolemic activity was evaluated by inducing hypercholesterolemia with high cholesterol diet for 21 days in experimental animals. Results: In VVME, total tannins, total flavonoids and total phenolic contents were found to be present in major amount. Both extract has significant in-vitro and in-vivo antioxidant efficacy. Different doses i.e. 100, 200 and 400 mg/kg of VVME and VVAE significantly attenuated the lipid levels. Moreover, VVME was found to be more effective as compared to VVAE and also, effectiveness was confirmed with histological results. Conclusion: It can be concluded that antioxidant and anti-hypercholesterolemic efficacy of Vitis vinifera might be due to presence of antioxidant property and active phytoconstituents.

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Section: In Vitro Antioxidant Activity Of Vvme and Vvaesupporting

confidence: 72%

Antioxidant and Anti-Hypercholesterolemic Potential of Vitis vinifera Leaves

Devi¹,

Singh²

2017

Phcog J

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“…Algae products have been shown experimentally to protect against atherosclerosis, dyslipidemia, and cancer progression (11)(12)(13). Edible algae such as purple laver (called "kim" in Korea, red alga Porphyra yezoensis ) and sea mustard ("miyeok", brown alga Undaria pinnatifida ) are also rich in biologically active substances.…”

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confidence: 99%

Algae Consumption and Risk of Type 2 Diabetes: Korean National Health and Nutrition Examination Survey in 2005

Lee

Kim

Vı́tek

et al. 2010

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe purpose of this study is to examine the relationship between dietary algae (seaweed) consumption and the risk of Type 2 diabetes mellitus in the Korean population. We analyzed data from the Korean National Health and Nutrition Examination Survey in 2005, a nationally representative survey. The study participants included 3,405 males and females aged 20-65 y. Participants were classified into four groups according to the quartiles of total algae consumption frequencies. Proportional odds models were used to assess the relationship between algae consumption and the risk of having diabetes or prediabetes, after adjustment for age, family history of diabetes, education, smoking, alcohol consumption, physical activity, body mass index, waist circumference, triglycerides, total energy intake and food group intakes. The frequency of algae consumption was positively correlated to the consumption of legumes, fruits, fish, and dairy products in both genders ( p Ͻ 0.001). The odds ratios (95% confidence interval) for diabetes vs. prediabetes vs. normoglycemia was 0.66 (0.43-0.99) for males and 0.80 (0.51-1.24) for females in the highest quartile of algae consumption compared to the lowest quartile. Our results suggest that dietary algae consumption may decrease the risk of diabetes mellitus in Korean men. A welldesigned prospective study is needed to confirm this association.

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“…Second, it has been reported to have certain beneficial physiological effects, such as y To whom correspondence should be addressed. Fax: +81-42-577-3020; E-mail: shinya-shibata@yakult.co.jp Abbreviations: ABC, ATP-binding cassette; CB, cholesterol + bile acid; CIF, Chlorella indigestible fraction; CP, Chlorella powder; CYP7A1, cholesterol 7-hydroxylase; CYP27A1, sterol 27-hydroxylase; FXR, farnesoid X receptor; HDL, high density lipoprotein; HNF-4, hepatocyte nuclear factor 4; HMGR, HMG-CoA reductase; LDL, low-density lipoprotein; LDLR, LDL receptor; LRH-1, liver receptor homolog-1; LXR, liver X receptor ; PCR, polymerase chain reaction; SHP, short heterodimer partner; SR-B1, scavenger receptor class B1; SREBP-2, sterol regulatory element-binding protein 2; TG, triglyceride hypocholesterolemic, [9][10][11][12] antihypertensive, 13) antioxidative, 14,15) and anti-tumor 16,17) activities in animal and human studies.…”

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confidence: 99%

“…12) However, the mechanism of the effect and the active components of Chlorella are not fully understood. Previously, we found that CP and an indigestible fraction of Chlorella had high bile acid-binding capacity in vitro and reduced serum and liver concentrations of cholesterol, decreased the concentration of fecal soluble bile acid, and enhanced the total amount of fecal neutral steroids in cholesterol-fed rats.…”

mentioning

confidence: 99%