Preventing Chemotherapy-Induced Nausea and Vomiting with Netupitant/Palonosetron, the First Fixed Combination Antiemetic: Current and Future Perspective

Aapro, Matti; Zhang, Li; Yennurajalingam, Sriram; LeBlanc, Thomas W.; Schwartzberg, Lee S.

doi:10.2217/fon-2018-0872

Cited by 10 publications

(8 citation statements)

References 92 publications

(207 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chemotherapy is one of the main means of cancer treatment at present. CINV, one of the common clinical complications of chemotherapy, is a complicated process mediated by several factors such as serotonin, substance P and dopamine 15. Nausea and vomiting occurring within 24 hrs after chemotherapy is acute CINV, which is caused by the binding of serotonin to 5-HT3 receptors in peripheral vagal afferents in the intestine 15.…”

Section: Discussionmentioning

confidence: 99%

“…CINV, one of the common clinical complications of chemotherapy, is a complicated process mediated by several factors such as serotonin, substance P and dopamine 15. Nausea and vomiting occurring within 24 hrs after chemotherapy is acute CINV, which is caused by the binding of serotonin to 5-HT3 receptors in peripheral vagal afferents in the intestine 15. If not treated in advance, patients will have serious nausea and vomiting after taking chemotherapeutic drugs, which will have adverse effects on patients in the followed treatment.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of ondansetron and [6]-gingerol on pica and gut microbiota in rats treated with cisplatin

Feng¹,

Cheng²,

Meng³

et al. 2019

DDDT

View full text Add to dashboard Cite

Purpose [6]-gingerol is one of the main components of ginger with many biological activities. In this study, the effects of ondansetron and [6]-gingerol on pica and gut microbiota in rats injected with cisplatin were evaluated. Materials and methods Rat model of cisplatin-induced pica was established, and the effects of ondansetron and [6]-gingerol on the gut microbiota were further studied by 16S rDNA gene analysis. Results The results showed that the total intake of kaolin of the rats injected with cisplatin was significantly increased, and treatment of ondansetron and [6]-gingerol in advance could significantly ameliorate the pica induced by cisplatin. The body weight of the rats injected with cisplatin was decreased compared with the control group. The 16S rDNA gene analysis has shown that ondansetron, [6]-gingerol and cisplatin could increase the relative abundance of Bacteroidetes and decrease Firmicutes on phylum level. Conclusion [6]-gingerol was as effective as ondansetron in the treatment of pica induced by cisplatin in rats, and it seemed that [6]-gingerol had the potential to ameliorate the alteration of gut microbiome, but it needs further study.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of ondansetron and [6]-gingerol on pica and gut microbiota in rats treated with cisplatin

Feng¹,

Cheng²,

Meng³

et al. 2019

DDDT

View full text Add to dashboard Cite

show abstract

“…19,20 Moreover, the co-administration of netupitant and palonosetron shows no changes in pharmacokinetic parameters as compared with single administration. 21…”

Section: Nk 1 -Rasmentioning

confidence: 99%

Management of Chemotherapy-Induced Nausea and Vomiting (CINV): A Short Review on the Role of Netupitant-Palonosetron (NEPA)

Lorusso

Russo

Giotta

et al. 2020

View full text Add to dashboard Cite

Introduction Antineoplastic drugs may induce several side effects, including chemotherapy-induced nausea and vomiting (CINV). Two neurotransmitters play a central role in mediating the emetic response: serotonin acting on the 5HT3 receptor and the substance P targeting the NK1 receptor. Indeed, a combination of a 5HT3 receptor antagonist (5HT3-RA) and a NK1 receptor antagonist (NK1-RA) together with dexamethasone has been shown to be very effective. In fact, this combination is actually widely used and recommended for CINV prophylaxis for highly emetogenic cisplatin-based adriamycin/cyclophosphamide (AC) and carboplatin-based regimens. NEPA (netupitant/palonosetron) is the only fixed combination antiemetic available and it is composed by the long-lasting second-generation 5HT3-RA palonosetron and the highly selective NK1-RA netupitant. Aim The aims of this short review were to analyze the role of NEPA in CINV prophylaxis and management taking in account the risk factors related to the patient and to the antineoplastic treatment. Evidence Review CINV development is not only correlated to the emetogenic potential of the antineoplastic drugs but is also very influenced by the patient characteristics and history, such as gender, age, alcohol intake, nausea during pregnancy and motion sickness. In pivotal and post-registration studies, NEPA has demonstrated to be effective and safe in both highly and moderately emetogenic chemotherapy. Conclusion A proper assessment of both chemotherapy- and patient-related risk factors is paramount to properly evaluate an appropriate prophylaxis of CINV and NEPA by simplifying the therapy, guarantees fully adherence to antiemetic guidelines, and consequently improves the control of CINV, especially in high risk patients.

show abstract

“…The complexity of NK 1 RA-based regimens' administration schedules differs on the basis of their individual pharmacologic properties. A graphic representation of the administration schedule of NK 1 RA-based regimens for the prevention of CINV associated with HEC and MEC is shown in Figure 2 [78].…”

Section: Administration Schedulementioning

confidence: 99%

Neurokinin-1 receptor antagonists: review of their role for the prevention of chemotherapy-induced nausea and vomiting in adults

Karthaus

Schiel

Ruhlmann

et al. 2019

Expert Review of Clinical Pharmacology

View full text Add to dashboard Cite

Introduction: The addition of neurokinin-1 receptor antagonists (NK 1 RAs) to standard prophylaxis of 5-hydroxytryptamine-3 RA (5-HT 3 RA) plus dexamethasone more effectively prevents chemotherapyinduced nausea and vomiting (CINV) associated with highly and moderately emetogenic chemotherapy. Areas covered: This review presents the evidence base for the use of oral and intravenous (IV) NK 1 RAs, focusing on the pharmacologic and clinical properties as a class, and highlighting differences between agents. A PubMed literature search was conducted from 2000 to 2018. Expert opinion: Adherence to international antiemetic guidelines remains a clinical challenge. Strategies to simplify antiemetic regimens and facilitate their administration may improve compliance and treatment outcomes. The use of fixed-combination antiemetics offers clinical utility, in combining an NK 1 RA with a 5-HT 3 RA in a single oral dose. The use of long-lasting NK 1 RAs and administering CINV prophylaxis closer to the time of chemotherapy may also assist with guideline and treatment compliance, diminishing the need for home-based administration, and potentially reducing resource utilization. The availability of IV and oral formulations of NK 1 RAs and NK 1 RA-5-HT 3 RA fixed combinations offers further utility, particularly for those patients unsuited for oral administration. However, safety considerations with respect to injection site toxicity and hypersensitivity reactions of the new NK 1 RA IV formulations deserve close attention.

show abstract

Preventing Chemotherapy-Induced Nausea and Vomiting with Netupitant/Palonosetron, the First Fixed Combination Antiemetic: Current and Future Perspective

Cited by 10 publications

References 92 publications

<p>Effects of ondansetron and [6]-gingerol on pica and gut microbiota in rats treated with cisplatin</p>

<p>Effects of ondansetron and [6]-gingerol on pica and gut microbiota in rats treated with cisplatin</p>

<p>Management of Chemotherapy-Induced Nausea and Vomiting (CINV): A Short Review on the Role of Netupitant-Palonosetron (NEPA)</p>

Neurokinin-1 receptor antagonists: review of their role for the prevention of chemotherapy-induced nausea and vomiting in adults

Contact Info

Product

Resources

About