Preventing cardiovascular heart disease: Promising nutraceutical and non-nutraceutical treatments for cholesterol management

The impact of probiotic yogurt consumption on lipid profiles in subjects with mild to moderate hypercholesterolemia: A systematic review and meta-analysis of randomized controlled trials

“…Treatment strategies to achieve optimal plasma cholesterol levels include both lifestyle and pharmacological interventions [32]. Statins, owing to their undisputed effectiveness in reducing plasma LDL-c levels, are the cornerstone of pharmacotherapy for hypercholesterolemia [33]. But the use of statins can be associated with musclerelated side effects, cognitive and memory problems, and new-onset diabetes in a dose-related manner [5].…”

Prevention and Treatment of Atherosclerosis: The Use of Nutraceuticals and Functional Foods

“…Berberine is being mostly studied in Asian subjects and is being marketed in the West for its hypocholesterolemic activities. Indeed, some reviews indicate that berberine can lower plasma cholesterol to an extent similar to that of statins, i.e., 20-30% (Johnston et al 2017). This effect is greater in subjects with higher basal cholesterolemia and also depends on individual genetics.…”

Nutraceuticals in the management of patients with statin‐associated muscle symptoms, with a note on real‐world experience

“…This may include isolated or assembled active food ingredients or a functional food . Several nutraceuticals (>40 in the literature) have been suggested to improve plasma lipid profiles, and their use as adjuncts to standard pharmacotherapy has been adopted and recommended by most international guidelines. In addition to their efficacy, their use also may be advantageous in terms of safety and tolerance, particularly in patients with documented SAMS …”