Preventing Cancer

Molokhia, Ehab; Perkins, Allen

doi:10.1016/j.pop.2008.07.009

Cited by 7 publications

(4 citation statements)

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“…Epidemiological studies have highlighted environmental factors as having a major role in the etiology of breast cancer. Genetic factors are obviously involved in carcinogenesis, but diet, as an environmental factor, is likely to have an influence on health [ 1 ], and particularly on tumor emergence [ 2 – 4 ]. For 40 years, differences in breast cancer incidence among women over the world and the influence of migrations on this incidence suggested that environmental factors such as dietary fat may play a role in this disease [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Polymeric nanocapsules prevent oxidation of core-loaded molecules: evidence based on the effects of docosahexaenoic acid and neuroprostane on breast cancer cells proliferation

Roy

Oliveira

Oger

et al. 2015

J Exp Clin Cancer Res

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BackgroundNanocapsules, as a delivery system, are able to target drugs and other biologically sensitive molecules to specific cells or organs. This system has been intensively investigated as a way to protect bioactives drugs from inactivation upon interaction with the body and to ensure the release to the target. However, the mechanism of improved activity of the nanoencapsulated molecules is far from being understood at the cellular and subcellular levels. Epidemiological studies suggest that dietary polyunsaturated fatty acids (PUFA) can reduce the morbidity and mortality from breast cancer. This influence could be modulated by the oxidative status of the diet and it has been suggested that the anti-proliferative properties of docosahexaenoic acid (DHA) are enhanced by pro-oxidant agents.MethodsThe effect of encapsulation of PUFA on breast cancer cell proliferation in different oxidative medium was evaluated in vitro. We compared the proliferation of the human breast cancer cell line MDA-MB-231 and of the non-cancer human mammary epithelial cell line MCF-10A in different experimental conditions.ResultsDHA possessed anti-proliferative properties that were prevented by alpha-tocopherol (an antioxidant) and enhanced by the pro-oxidant hydrogen peroxide that confirms that DHA has to be oxidized to exert its anti-proliferative properties. We also evaluated the anti-proliferative effects of the 4(RS)-4-F4t-neuroprostane, a bioactive, non-enzymatic oxygenated metabolite of DHA known to play a major role in the prevention of cardiovascular diseases. DHA-loaded nanocapsules was less potent than non-encapsulated DHA while co-encapsulation of DHA with H2O2 maintained the inhibition of proliferation. The nanocapsules slightly improves the anti-proliferative effect in the case of 4(RS)-4-F4t-neuroprostane that is more hydrophilic than DHA.ConclusionOverall, our findings suggest that the sensitivity of tumor cell lines to DHA involves oxidized metabolites. They also indicate that neuroprostane is a metabolite participating in the growth reducing effect of DHA, but it is not the sole. These results also suggest that NC seek to enhance the stability against degradation, enhance cellular availability, and control the release of bioactive fatty acids following their lipophilicities.

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Section: Introductionmentioning

confidence: 99%

Polymeric nanocapsules prevent oxidation of core-loaded molecules: evidence based on the effects of docosahexaenoic acid and neuroprostane on breast cancer cells proliferation

Roy

Oliveira

Oger

et al. 2015

J Exp Clin Cancer Res

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“…Genetic factors are obviously involved in carcinogenesis, but diet is an environmental factor that is likely to have an influence on health (1), and particularly on tumor emergence (2)(3)(4). It has been shown that n-3 polyunsaturated, long-chain fatty acids (PUFAs), such as docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA), are able to play an important preventive role in cardiovascular disease (5) and cancer (6).…”

Section: Introductionmentioning

confidence: 99%

Docosahexaenoic acid intake decreases proliferation, increases apoptosis and decreases the invasive potential of the human breast carcinoma cell line MDA-MB-231

Blanckaert

Ulmann²,

Mimouni³

et al. 2010

Int J Oncol

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Abstract. Breast cancer is the most common cancer in women in industrialized countries. Environmental factors, such as differences in diet are likely to have an important influence on cancer emergence. Among these factors, n-3 polyunsaturated-fatty acids, such as docosahexaenoic acid (DHA), are good candidates for preventing breast cancer. Here we investigate the effect of DHA on the human breast cancer cell line MDA-MB-231 and show that DHA incorporation i) has an anti-proliferative effect, ii) induces apoptosis via a transient increase in caspase-3 activity and the promotion of nuclear condensation, and iii) reduces the invasive potential of MDA-MB-231 cells. To conclude, DHA may have beneficial effects as a result of slowing the proliferation of tumor cells, and minimizing their metastatic potential. IntroductionFor several decades, genetic and environmental factors have been explored in order to elucidate the appearance of tumors. Genetic factors are obviously involved in carcinogenesis, but diet is an environmental factor that is likely to have an influence on health (1), and particularly on tumor emergence (2-4). It has been shown that n-3 polyunsaturated, long-chain fatty acids (PUFAs), such as docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA), are able to play an important preventive role in cardiovascular disease (5) and cancer (6). This conclusion is based partly on the observation that the incidence of these diseases is lower in Japanese people, whose diet is seafood based, resulting in a more balanced ratio between n-3 and n-6 PUFA than that of the Western diet (7). Even though this resource may be depleted in the future by the overharvesting of n-3 PUFA rich fish, it could be replaced by using marine microalgae, which have been identified as an important alternative source of DHA and EPA (8,9). Breast cancer is one of the cancers most frequently observed in industrialized countries, and the one with the highest incidence in women. Epidemiological studies have shown that the rate of breast cancer is 4 to 5 times higher in Western countries than in Japan (1,10). The mechanism by which DHA and EPA could provide protection against the appearance of a tumor, or directly influence cancer cells by reducing their malignancy, remains unclear, since cohort studies do not reveal any correlation between fat intake and breast cancer (1). Nevertheless, some evidence hints that DHA not only acts as an anti-proliferative agent by lengthening the cell cycle between the G2/M transition (11), but is also a proapoptotic factor, increasing caspase-3 and Bax (12,13). In addition, DHA has been shown to affect cell proliferation, whatever its source (i.e., fish oil or microalgae) (14). It has also been shown that the n-3 PUFAs and DHA, in particular, can act on lipid peroxidation as well as on the proteins implicated in the ROS mechanism leading to cell death (15,16).In this study, the effects of two concentrations of DHA (20 and 100 μM) were investigated on the human breast cancer cell line MDA-MB-231. DHA incorpo...

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“…CM dietary herbs (supplements) or Chinese herbal medicine may play a crucial role in preventing the incidence, recurrence, and metastasis of breast cancer. Many experimental studies have demonstrated that some foods representative of the CM classifications could reduce the risk of cancer [30–32], and that there is a relationship between the use of CM herbs or related Chinese herbal medicine and the reduced incidence of breast cancer [33]. …”

Section: Discussionmentioning

confidence: 99%

Relationship between Chinese medicine dietary patterns and the incidence of breast cancer in Chinese women in Hong Kong: a retrospective cross-sectional survey

et al. 2017

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BackgroundThis retrospective cross-sectional study aimed to investigate the relationship between Chinese medicine (CM) dietary patterns (hot, neutral, and cold) and the incidence of breast cancer among Chinese women in Hong Kong.MethodsBreast cancer cases (n = 202) and healthy controls (n = 202) were matched according to demographics. Chinese women residing in Hong Kong for the past 7 years were recruited by media advertisements (e.g., via newspapers, radio, and posters). The control participants were recruited by convenience sampling from health workshops held in clinics and communities of 15 districts of Hong Kong. After completing test–retest reliability, all participants were asked to complete diet pattern questionnaires about their food preferences and dietary patterns. The Student’s unpaired t test, Chi square test, and logistic regression were conducted using SPSS software.ResultsThree major CM dietary patterns were identified: hot, neutral, and cold. The participants with breast cancer exhibited a stronger preference for hot food than the control group (Chi square test, P < 0.001). A higher frequency of breast cancer was associated with a higher frequency of dining out for breakfast (4–5 times per week, Chi square test, P = 0.015; 6–7 times per week, Chi square test, P < 0.001) and lunch (4–5 times per week, Chi square test, P < 0.001; 6–7 times per week, Chi square test, P = 0.006). The participants with no history of breast cancer consumed CM supplements and Guangdong soups (1–2 times per week, Chi square test, P = 0.05; >3 times per week, Chi square test, P < 0.001) more frequently than those with breast cancer.ConclusionsNon-breast cancer participants adopted a neutral (healthy and balanced) dietary pattern, and consumed CM supplements and Guangdong soups more frequently.Electronic supplementary materialThe online version of this article (doi:10.1186/s13020-017-0138-9) contains supplementary material, which is available to authorized users.

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Preventing Cancer

Cited by 7 publications

References 50 publications

Polymeric nanocapsules prevent oxidation of core-loaded molecules: evidence based on the effects of docosahexaenoic acid and neuroprostane on breast cancer cells proliferation

Polymeric nanocapsules prevent oxidation of core-loaded molecules: evidence based on the effects of docosahexaenoic acid and neuroprostane on breast cancer cells proliferation

Docosahexaenoic acid intake decreases proliferation, increases apoptosis and decreases the invasive potential of the human breast carcinoma cell line MDA-MB-231

Relationship between Chinese medicine dietary patterns and the incidence of breast cancer in Chinese women in Hong Kong: a retrospective cross-sectional survey

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