Preventing and Treating Colic

Indrio, Flavia; Dargenio, Vanessa Nadia; Giordano, Paola; Francavilla, Ruggiero

doi:10.1007/5584_2018_315

Cited by 8 publications

(6 citation statements)

References 72 publications

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“…A lower diversity and stability of the gut microbiota was reported in subjects with IC during the first 2 weeks of life . These alterations suggest that a state of gut dysbiosis might play a role in the expression of IC symptoms, modulating various neural, endocrine, immune and humoral signalling pathways …”

Section: Introductionmentioning

confidence: 99%

“…4,5 These alterations suggest that a state of gut dysbiosis might play a role in the expression of IC symptoms, modulating various neural, endocrine, immune and humoral signalling pathways. [4][5][6] Considering that dysbiosis could play a role in the pathogenesis of IC, there is an interest in gut microbiota modulation, including the use of probiotics, for the management of IC. Bifidobacterium animalis subsp.…”

Section: Introductionmentioning

confidence: 99%

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The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB‐12^® in infant colic: A randomised, double blind, placebo‐controlled trial

Nocerino

Filippis

Cecere

et al. 2019

Aliment Pharmacol Ther

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Summary Background The pathogenesis of infant colic is poorly defined. Gut microbiota seems to be involved, supporting the potential therapeutic role of probiotics. Aims To assess the rate of infants with a reduction of ≥50% of mean daily crying duration after 28 days of intervention with the probiotic Bifidobacterium animalis subsp. lactis BB‐12® (BB‐12). Secondary outcomes were daily number of crying episodes, sleeping time, number of bowel movements and stool consistency. Methods Randomized controlled trial (RCT) on otherwise healthy exclusively breastfed infants with infant colic randomly allocated to receive BB‐12 (1 × 109 CFU/day) or placebo for 28 days. Gut microbiota structure and butyrate, beta‐defensin‐2 (HBD‐2), cathelicidin (LL‐37), secretory IgA (sIgA) and faecal calprotectin levels were assessed. Results Eighty infants were randomised, 40/group. The rate of infants with reduction of ≥50% of mean daily crying duration was higher in infants treated with BB‐12, starting from the end of 2nd week. No infant relapsed when treatment was stopped. The mean number of crying episodes decreased in both groups, but with a higher effect in BB‐12 group (−4.7 ± 3.4 vs −2.3 ± 2.2, P < 0.05). Mean daily stool frequency decreased in both groups but the effect was significantly higher in the BB‐12 group; stool consistency was similar between the two groups. An increase in Bifidobacterium abundance (with significant correlation with crying time reduction), butyrate and HBD‐2, LL‐37, sIgA levels associated with a decrease in faecal calprotectin level were observed in the BB‐12 group. Conclusions Supplementation with BB‐12 is effective in managing infant colic. The effect could derive from immune and non‐immune mechanisms associated with a modulation of gut microbiota structure and function.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB‐12^® in infant colic: A randomised, double blind, placebo‐controlled trial

Nocerino

Filippis

Cecere

et al. 2019

Aliment Pharmacol Ther

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“…The prevalence of IC was reported to be 15%-30%. Besides, it is more common in families experiencing childcare for the first time (3)(4)(5). They not only have periods of abdominal pain, excessive crying, and insomnia in early infancy but also may experience behavioral and mood disorders, hyperactivity, and migraine at older ages (6,7).…”

Section: Contextmentioning

confidence: 99%

Parental Factors Affecting the Incidence of Infantile Colic: A Systematic Review

et al. 2021

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Context: Infantile Colic (IC) is an essential problem in infancy that is influenced by factors related to infants and parents. The parental factors associated with colic have not been comprehensively assessed. Objectives: The present systematic review was conducted to investigate the parental factors affecting the incidence of IC. Data Sources: Databases, including PubMed, Web of Science, Scopus, Science Direct, Google scholar, as well as Scientific Information Database (SID), and Magiran (Iranian websites) were searched to identify all eligible papers concerning parental factors affecting infantile CI. The registration number of this study was CRD42020163518 in the PROSPERO database. Study Selection: A total of 423 relevant articles published up to the end of December 2019 were assessed. The selected articles were screened based on duplicated, eligibility criteria, and quality appraisal. The main inclusion criteria were observational studies and articles in Persian and English languages. Data Extraction: The Mesh keywords and Boolean operators included (“risk factors” OR “causality”) AND (“parents” OR “fathers” OR “mothers”) AND (“infant”) AND (“colic”). Consequently, 18 papers were thoroughly studied and the related data were extracted. Two researchers independently performed the data extraction and quality assessment based on the STROBE checklist from the observational studies. The information of selected studies was recorded in a table, i.e. consisted of authors’ names, purpose, design, population, and main results. Results: Final articles consisted of 10 prospective, 6 cross-sectional, and 2 case-control studies. Eventually, the effective factors were placed in 6 categories, as follows: psychological factors, physical factors, taking medications, perinatal factors, family’s socioeconomic status, and maternal diet. The most important characteristics predisposing to IC were parental depression, anxiety, smoking, maternal history of migraine, young age, primiparity, low family support, high socioeconomic status, high-risk pregnancies, and delivery, taking antibiotics, as well as the consumption of celery, onions, and bananas. Conclusions: Various parental factors affect the incidence of colic. Identifying these risk factors and accurate planning can be beneficial in the prevention and treatment of IC.

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“…It is a behavioral manifestation in 1-4-months-old infants that often results in excessive crying and restlessness. 2 , 3 The prevalence of colic was reported to be 2%-73% worldwide. 3 , 4 In Iran, a prevalence rate of 20% was reported in 2008, 5 no new statistics on the disorder are available in Iran.…”

Section: Introductionmentioning

confidence: 99%

Psychometric Assessment of Infant Colic Scale in Iranian Population

Montazeri,

Hasanpour,

Mirghafourvand

et al. 2023

J Caring Sci

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Introduction: Infant colic, causing excessive crying, poses anxiety for parents and a challenge for pediatricians and nurses. The Infant Colic Scale (ICS) serves to assess the severity and causal factors of colic. Despite its significance, the psychometric properties of ICS have not been evaluated in the Iranian population. This study seeks to address this gap by assessing the psychometric properties of ICS in Iran. Methods: A sample of 220 mothers with 2–16-week-old term infants diagnosed with infantile colic was selected through convenience sampling. Following forward and back-translation, the face validity, content validity, and construct validity of ICS were systematically evaluated. Reliability was examined through both internal consistency (Cronbach’s alpha) and test-retest stability methods. Results: Content validity index (CVI) and content validity ratio (CVR) values for ICS were 0.94 and 0.81, respectively. The good fit indices confirmed the validity of the five-factor structure. Cronbach’s alpha coefficient and intraclass correlation coefficient (ICC) were 0.71 and 0.94, respectively. Conclusion: The Persian version of ICS is a valid and reliable tool, suitable for assessing infantile colic in the Iranian population. Future studies and clinical practice can utilize this tool to identify major causes of this disorder in the Iranian context.

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Preventing and Treating Colic

Cited by 8 publications

References 72 publications

The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB‐12^® in infant colic: A randomised, double blind, placebo‐controlled trial

The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB‐12^® in infant colic: A randomised, double blind, placebo‐controlled trial

Parental Factors Affecting the Incidence of Infantile Colic: A Systematic Review

Psychometric Assessment of Infant Colic Scale in Iranian Population

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Preventing and Treating Colic

Cited by 8 publications

References 72 publications

The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB‐12® in infant colic: A randomised, double blind, placebo‐controlled trial

The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB‐12® in infant colic: A randomised, double blind, placebo‐controlled trial

Parental Factors Affecting the Incidence of Infantile Colic: A Systematic Review

Psychometric Assessment of Infant Colic Scale in Iranian Population

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Product

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The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB‐12^® in infant colic: A randomised, double blind, placebo‐controlled trial

The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB‐12^® in infant colic: A randomised, double blind, placebo‐controlled trial