Preventative Effect of a Flavonoid, Enzymatically Modified Isoquercitrin on Ocular Symptoms of Japanese Cedar Pollinosis

Hirano, Tôru; Kawai, Masao; Arimitsu, Junsuke; Ogawa, Masako; Kuwahara, Yusuke; Hagihara, Keisuke; Shima, Yoshihito; Narazaki, Masashi; Ogata, Atsushi; Koyanagi, Mihoko; Kai, Tomoko; Shimizu, Ryosuke; Moriwaki, Masamitsu; Suzuki, Yukio; Ogino, Satoshi; Kawase, Ichiro; Tanaka, Toshio

doi:10.2332/allergolint.08-oa-0070

Cited by 43 publications

(29 citation statements)

References 39 publications

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confidence: 99%

“…Flavonoids, such as apple polyphenols, Pycnogenol ® and isoquercitrin, have been applied in the prevention of seasonal allergy [39][40][41]. Although the cohort of the studies was small, flavonoid intake over a long period seems to be effective for the relief of allergic symptoms [39][40][41]. In the case of cocoa, further studies need to be performed to establish its anti-allergic dose in humans, although following the conversion of animal doses into human equivalent doses [42], the 10% cocoa diet was equivalent to 0.908 g cocoa/kg human per day.…”

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confidence: 99%

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A diet enriched with cocoa prevents IgE synthesis in a rat allergy model

Abril-Gil¹,

Massot-Cladera²,

Pérez-Cano³

et al. 2012

Pharmacological Research

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Previous studies in young rats reported the impact of cocoa intake on healthy immune status and allow suggesting it may have a role in the prevention of some immune-mediated diseases. The aim of this study was to ascertain the effect of a cocoa diet in a model of allergy in young rats. Three-week-old Brown Norway rats were immunized by i.p. injection of ovalbumin (OVA) with alum as adjuvant and Bordetella pertussis toxin. During the next 4 weeks rats received either a cocoa diet (containing 0.2% polyphenols, w/w) or a standard diet. Animals fed a standard diet showed high concentrations of anti-OVA IgG1, IgG2a, IgG2b and high anti-OVA IgE titres, which is the antibody involved in allergic response. In contrast, animals fed a cocoa diet showed significantly lower concentrations of anti-OVA IgG1 and IgG2a antibodies. Interestingly, the cocoa diet prevented anti-OVA IgE synthesis and decreased total serum IgE concentration. Analysis of cytokine production in lymph node cells at the end of the study revealed that, in this compartment, the cocoa diet decreased the tumor necrosis factor (TNF) -α and the interleukin (IL) -10 secretion but not IL-4 production. In conclusion, a cocoa-enriched diet in young rats produces an immunomodulatory effect that prevents anti-allergen IgE synthesis, suggesting a potential role for cocoa flavonoids in the prevention or treatment of allergic diseases. 3

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confidence: 99%

mentioning

confidence: 99%

A diet enriched with cocoa prevents IgE synthesis in a rat allergy model

Abril-Gil¹,

Massot-Cladera²,

Pérez-Cano³

et al. 2012

Pharmacological Research

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“…Anterior ocular inflammation may be due to the up-regulation of COX-2 (Oka et al, 2004), and certain chalcone derivatives were reported to potently inhibit iNOS-catalyzed NO production by iNOS down-regulation and/or iNOS inhibition, depending on their chemical structure . Besides, quercetin, also a flavonoid as chalcones, was shown to relieve ocular symptoms caused by cedar pollinosis in japanese patients (Hirano et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Chalcones from Myracrodruon urundeuva are efficacious in guinea pig ovalbumin-induced allergic conjunctivitis

Albuquerque¹,

Leal²,

Bandeira³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The objective of the study was to verify the effects of dimeric chalcones (urundeuvines A, B, and C) from Myracrodruon urundeuva Allemão, Anacardiaceae (a Brazilian anti-inflammatory species), on an allergic conjunctivitis model. Male guinea-pigs were sensitized with two intraperitoneal injections of ovalbumin (10 μg dissolved in 0.5 mL saline and emulsified in 0.5 mL Freund's adjuvant), at days 0 and 7. At day 24, the animals were submitted to an ocular instillation (right eyes) with ovalbumin. At the next day, the animals were treated with chalcones (0.5 mg, three times a day for 7 days), 0.1% fluormetalone acetate (0.05 mg, as the reference drug) or saline. After anesthesia of the animals, enucleations of their corneas and conjunctivas were carried out for morphometric and histological analyses, at days 1, 3 and 7. Their radical scavenging activity and action on myeloperoxidase were also determined. We demonstrated that chalcones from M. urundeuva stem barks presented anti-inflammatory and antioxidant effects, and drastically inhibited the MPO activity, pointing them as candidates for the treatment of allergic conjunctivitis and other inflammatory conditions.

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“…We therefore examined whether flavonoids might be effective for symptoms associated to Japanese cedar pollinosis (JCP) 29,30 . The flavonoid used in our study was enzymatically modified isoquercitrin (EMIQ), which is a mixture of quercetin glycosides and consists of isoquercitrin and its maltooligosaccharides.…”

Section: Intervention Studies In Humansmentioning

confidence: 99%

Flavonoids as complementary medicine for allergic diseases: current evidence and future prospects

Tanaka¹

2013

OA Alternative Medicine

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Preventative Effect of a Flavonoid, Enzymatically Modified Isoquercitrin on Ocular Symptoms of Japanese Cedar Pollinosis

Abstract: Intake of the quercetin glycoside EMIQ proved to be effective for the relief of ocular symptoms caused by Japanese cedar pollinosis.

Cited by 43 publications

References 39 publications

A diet enriched with cocoa prevents IgE synthesis in a rat allergy model

A diet enriched with cocoa prevents IgE synthesis in a rat allergy model

Chalcones from Myracrodruon urundeuva are efficacious in guinea pig ovalbumin-induced allergic conjunctivitis

Flavonoids as complementary medicine for allergic diseases: current evidence and future prospects

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