Prevalensi dan Evaluasi Kesesuaian Penggunaan Antibiotik pada Pasien dengan Infeksi Methicillin Resistant Staphylococcus Aureus di RSUP Dr. Soeradji Tirtonegoro Klaten

Nuryah, Atik; Yuniarti, Nunung; Puspitasari, Ika

doi:10.22146/farmaseutik.v15i2.47911

Cited by 15 publications

(14 citation statements)

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“…This study showed that male MRSA patients were 583 or 9.4% (range 32.5% -71.4%). The previous research supports the result of this study that there were more male MRSA patients (69.6%) [5]. It can be affected by several factors, such as poor hand hygiene rates in the male population compared to the female population, and it is also influenced by the hormone possessed by the female population, namely estrogen, which may affect the virulence factor Staphylococcus aureus bacteria [25].…”

Section: Mrsa Patients' Characteristicsupporting

confidence: 85%

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Vancomycin Monotherapy vs Alternative Antibiotics for MRSA Patients: A Systematic Review

Salsabil¹,

Rochmanti²,

Widodo³

2021

IJRP

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Background: MRSA (Methicillin-resistant Staphylococcus Aureus) has become a global epidemic at a high rate. MRSA is one of the most difficult infections to treat because of its resistance to several antibiotics. Nowadays, there are still many antibiotics for MRSA in the world. This study discusses antibiotic usage against MRSA infection. It expects to contribute to the third SDG in terms of infection therapy. Method: Seven studies used for this systematic review study were conducted through PubMed and ClinicalTrials.gov databases. Aims: This study compared MRSA patients treated with vancomycin monotherapy and alternative antibiotics. Result: The highest use alternative antibiotics besides vancomycin were linezolid with 27.8%, cotrimoxazole 8.1%, daptomycin was 6.7%, and combination vancomycin plus flucloxacillin was 3.2%. Treatment duration for MRSA, treated using vancomycin compared with alternative antibiotics, did not show a significant difference. Patients treated using vancomycin mostly had higher mortality than the alternative antibiotics. The most dominant age infected by MRSA is the elderly population. Gender dominated by males 59.4% (range from 32.5% to 71.4%). The main comorbidity of the patients was heart disease, diabetes mellitus, and lung disease. Conclusion: Alternative antibiotics mostly have lower mortality compared to vancomycin. Insignificant treatment duration appears between vancomycin and alternative antibiotics. Most patients with MRSA were elderly, male, and patients with comorbid heart disease, diabetes mellitus, and lung disease.

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Section: Mrsa Patients' Characteristicsupporting

confidence: 85%

“…Another study also conducted in Trivandrum, India, in 2018 showed that all MRSA isolates were sensitive to the linezolid and vancomycin [4]. In Indonesia, an analytical study conducted in 2019 showed that the antibiotic chloramphenicol is very sensitive for MRSA, although it is not under therapeutic guidelines for MRSA [5].…”

Section: Introductionmentioning

confidence: 99%

Vancomycin Monotherapy vs Alternative Antibiotics for MRSA Patients: A Systematic Review

Salsabil¹,

Rochmanti²,

Widodo³

2021

IJRP

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“…Berdasarkan hasil penelitian 2 sebelumnya prevalensi infeksi Methicillin Resistant Staphylococcus Aureus (MRSA) yang dilaksanakan di RSUP Dr. Soeradji Tirtonegoro Klaten, menunjukkan bahwa terjadi peningkatan infeksi dari periode 2015 hingga 2018. Peningkatan yang terjadi yaitu 7,69% di tahun 2015, 5,63% di tahun 2016, 10,81% di tahun 2017 dan 12,94% di tahun 2018 [2].…”

Section: Pendahuluanunclassified

Penggunaan Antibiotik Restriksi Pada Pasien Apendiks Akut, Batu Ginjal dan Cedera Kepala Ringan (CKR) di Bangsal Bedah RSUD H. Abdul Manap Kota Jambi Periode 2017-2019

Andriani¹,

Rahmadevi²,

Fauziah³

2021

Pharmasci

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Tingginya prevalensi penyakit infeksi di Indonesia menyebabkan penggunaan antibiotik meningkat. Penggunaan antibiotik yang tidak tepat dapat menyebabkan terjadinya resiko terhadap resistensi antibotik. Penelitian ini bertujuan untuk mengetahui persentase penggunaan antibiotik restriksi pada pasien apendiks akut, batu ginjal dan cedera kepala ringan (CKR) di bangsal bedah Rumah Sakit Umum Daerah H. Abdul Manap Kota Jambi periode 2017 – 2019. Penelitian ini merupakan penelitian observasional yang di analisa secara deskriptif dengan pengambilan data secara retrospektif pada rekam medis pasien apendiks akut, batu ginjal dan CKR yang mendapat terapi antibiotik sesuai dengan kriteria inklusi. Hasil penelitian ini menunjukkan bahwa dari 117 pasien didapatkan sebanyak 36 sampel yang memenuhi kriteria inklusi. Persentase penggunaan antibiotik restriksi terbanyak adalah ciprofloxacin (21,3%) sedangkan levofloxacin (9,4 %). Persentase antibiotik restriksi pada diagnosa apendiks akut yaitu (29%) di tahun 2017, (28%) tahun 2018 dan (31%) tahun 2019 pasien, untuk diagnosa batu ginjal (42%) tahun 2017, (54%) tahun 2018 dan (50%) tahun 2019, sedangkan diagnosa CKR (22%) tahun 2017, (16%) tahun 2018 dan (18%) tahun 2020. Berdasarkan hasil tersebut dapat disimpulkan penggunaan antibiotik terbanyak adalah ciprofloxacin 21,3%, persentase penggunaan antibiotik restriksi pada diagnosa apendiks akut, batu ginjal dan CKR terjadi peningkatan dan penurunan.

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“…Staphylococcus aureus is a gram-positive facultative anaerobic bacterium that acts as a commensal organism and an important opportunistic pathogen for humans, which can cause bacteremic sepsis, endocarditis, pneumonia, osteomyelitis, arthritis, and skin diseases [1][2][3][4]. A study in Dr. Soeradji Tirtonegoro's hospital revealed that isolates were resistant to tetracycline antibiotics (64.8%), erythromycin (53.7%), and cloxacillin (40.7%) [5].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial test of ethanol extract of "Cocor-Bebek" leaves (Kalanchoe pinnata) against the growth of Staphylococcus aureus and Salmonella typhi

Sudayasa¹,

Dewi²,

Ariasnitra³

et al. 2022

GSC Biol. and Pharm. Sci.

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This study aims to determine the antibacterial effect of the Ethanol Extract of Cocor bebek leaves (Kalanchoe pinnata) on the growth of Staphylococcus aureus and Salmonella typhi. The study is a true experimental, using a posttest only control group design with the independent variable being the extract of cocor bebek leaves (Kalanchoe pinnata). This study found that extracts of cocor bebek leaves (Kalanchoe pinnata) with a concentration of 7.5% and 15% had no inhibitory power, while at concentrations of 30% and 60% had weak inhibitory power as the minimum inhibitory power, and a concentration of 100% had inhibitory power, and strong on the growth of Staphylococcus aureus bacteria. Meanwhile for the growth of Salmonella typhi, a concentration of 7.5% from 3 repetitions had an average inhibition zone of 1.2 mm. for a concentration of 15% has an average inhibition zone diameter of 3 repetitions of 2.2 mm. concentration of 30% from 3 rolls has an average inhibition zone of 12.6 mm. for a concentration of 60% has an average inhibition zone of 3 repetitions of 19.8mm. There is antibacterial activity of ethanolic extract of cocor bebek leaf (Kalanchoe pinnata) against the growth of Staphylococcus aureus and Salmonella typhi.

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Prevalensi dan Evaluasi Kesesuaian Penggunaan Antibiotik pada Pasien dengan Infeksi Methicillin Resistant Staphylococcus Aureus di RSUP Dr. Soeradji Tirtonegoro Klaten

Cited by 15 publications

References 0 publications

Vancomycin Monotherapy vs Alternative Antibiotics for MRSA Patients: A Systematic Review

Vancomycin Monotherapy vs Alternative Antibiotics for MRSA Patients: A Systematic Review

Penggunaan Antibiotik Restriksi Pada Pasien Apendiks Akut, Batu Ginjal dan Cedera Kepala Ringan (CKR) di Bangsal Bedah RSUD H. Abdul Manap Kota Jambi Periode 2017-2019

Antibacterial test of ethanol extract of "Cocor-Bebek" leaves (Kalanchoe pinnata) against the growth of Staphylococcus aureus and Salmonella typhi

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