Prevalencia, tipo de epilepsia y uso de fármacos antiepilépticos en atención primaria

Fernández-Suárez, E; Villa-Estébanez, R; García-Martínez, A.N.; Ja, Fidalgo-González; Aa, Zanabili Al-Sibbai; Salas-Puig, Javier

doi:10.33588/rn.6012.2015038

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…One of the interesting observations was the unsuitable use of combinations of CBZ and OXC which is not recommended depending on the indications, target receptor and side effects. The use of CBZ in our study, partially matched a previous primary care study which reported it as the second choice [19]. In one study addressing only idiopathic generalized epilepsy, LMT was prescribed in 3% of the cases and this conforms to our findings [25].…”

Section: Discussionsupporting

confidence: 89%

Clinical Characteristics and Current Medical Practice in a Group of Sudanese Patients with Epilepsy: A Cross Sectional Hospital Based-Study

Elsayed¹,

Issa²,

Mahmoud³

et al. 2021

CRCM

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Introduction: The epilepsy classification in under developed countries faces many difficulties in reporting, work-up and management strategies. Exploring local practice in general hospitals will positively add to the welfare of patients with epilepsy. The objectives of this study were to assess the current medical practice in epilepsy work up and to study the selection of AEDs as per ILAE guidelines. Methods: This was a cross sectional-retrospective hospital based study, conducted between April and September 2016 in Omdurman Teaching Hospital, Khartoum, Sudan. Patients aged 18 years old and above were enrolled. Epilepsy was defined as having at least two non-provoked seizures in the least 6 months in a patient who was assessed by clinical review and electroencephalogram (EEG). Epilepsy was classified as generalized, focal or unclassified. Medications refer to all internationally licensed antiepileptic medications (AEDs) in 2016. Results: One hundred adult Sudanese patients were enrolled for this study. The most common event described during the ictal phase was tongue biting in 50% of participants followed by body stiffness in 46%. Epilepsy was classified as generalized in 84%, focal in 11% and unclassified in 5% patients. In generalized epilepsy, the MRI detected 23.3% abnormal findings higher than the CT which detected 14.8% (4/27), p value = 0.032. In focal epilepsy, the CT detected 75% abnormal findings higher than the MRI which detected 33.3%, p value = 0.02. The AEDs used were as follows: Carbamazepine (CBZ) 48%, Na valproate (VP) 33%, Lamotrigine

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Section: Discussionsupporting

confidence: 89%

Clinical Characteristics and Current Medical Practice in a Group of Sudanese Patients with Epilepsy: A Cross Sectional Hospital Based-Study

Elsayed¹,

Issa²,

Mahmoud³

et al. 2021

CRCM

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“…Sci. 2021, 22, 3358 2 of 16 active form of epilepsy is around 5-10 people in 1000 [1][2][3]. Epileptics are at an increased risk of death (about 1.6-4.1 times higher compared to the general population), which is associated with epileptic seizures, epileptic state, suicide, or sudden unexpected death in epilepsy (SUDEP) [4].…”

Section: Introductionmentioning

confidence: 99%

Effect of Chronic Administration of 5-(3-chlorophenyl)-4-Hexyl-2,4 -Dihydro-3H-1,2,4-Triazole-3-Thione (TP-315)—A New Anticonvulsant Drug Candidate—On Living Organisms

Makuch-Kocka

Andres-Mach

Zagaja

et al. 2021

IJMS

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About 70 million people suffer from epilepsy—a chronic neurodegenerative disease. In most cases, the cause of the disease is unknown, but epilepsy can also develop as the result of a stroke, trauma to the brain, or the use of psychotropic substances. The treatment of epilepsy is mainly based on the administration of anticonvulsants, which the patient must most often use throughout their life. Despite significant progress in research on antiepileptic drugs, about 30% of patients still have drug-resistant epilepsy, which is insensitive to pharmacotherapy used so far. In our recent studies, we have shown that 4-alkyl-5-aryl-1,2,4-triazole-3-thiones act on the voltage-gated sodium channels and exhibit anticonvulsant activity in an MES (maximal electroshock-induced seizure) and 6Hz test in mice. Previous studies have shown their beneficial toxic and pharmacological profile, but their effect on a living organism during chronic use is still unknown. In the presented study, on the basis of the previously conducted tests and the PAMPA (parallel artificial membrane permeability assay) BBB (blood–brain barrier) test, we selected one 1,2,4-triazole-3-thione derivative—TP-315—for further studies aimed at assessing the impact of its chronic use on a living organism. After long-term administration of TP-315 to Albino Swiss mice, its effect on the functional parameters of internal organs was assessed by performing biochemical, morphological, and histopathological examinations. It was also determined whether the tested compound inhibits selected isoforms of the CYP450 enzyme system. On the basis of the conducted tests, it was found that TP-315 does not show nephrotoxic nor hepatotoxic effects and does not cause changes in hematological parameters. In vitro tests showed that TP-315 did not inhibit CYP2B6, CYP2D6, CYP3A4, or CYP3A5 enzymes at the concentration found in the serum of mice subjected to long-term exposure to this compound.

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“…This result was in line with prior research involving Asian and African studies [ 48 , 49 ]. However, other studies observed a higher proportion of focal seizures [ 32 , 50 , 51 ]. This discrepancy was ascribed to patients' and observers' inadequate detection of the early focal symptoms, which causes them to miss the onset and become aware of the patient's broad convulsion [ 52 ].…”

Section: Reviewmentioning

confidence: 85%

“…Furthermore, in other investigations, the degree of control over epileptic seizures was not altered by the administration of novel ASMs [ 58 , 59 ]. In earlier research, monotherapy was employed at a frequency of 48.6% to 60% [ 47 , 50 , 51 ].…”

Section: Reviewmentioning

confidence: 99%

Demographics, Clinical Characteristics, and Management Strategies of Epilepsy in Saudi Arabia: A Systematic Review

Almuqairsha,

Al-Harbi,

Alaidah

et al. 2024

Cureus

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Epilepsy accounts for a large part of the global burden of neurological disorders. This review aimed to assess the demographics, clinical characteristics, and management of patients with epilepsy in Saudi Arabia based on studies published from 2018 to 2023. A systematic review was carried out using PubMed, Medline, Embase, and Cochrane Library from January 2018 to January 2023, where key terms related to the epidemiology, clinical characteristics, treatment, and management strategy of epilepsy in Saudi Arabia were used to search for related studies. All relevant articles published in this period in the English language were included, and data about authors, year of the study, sample size, study design, demographic characteristics, clinical characteristics, and treatment strategy were collected. A male preponderance, a 6-24.9% family history of epilepsy, an equal distribution of focal and tonic-clonic epilepsy, EEG abnormalities of 19.7-70%, and a higher prevalence of monotherapy regimens were the main findings of this review.

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Prevalencia, tipo de epilepsia y uso de fármacos antiepilépticos en atención primaria

Cited by 5 publications

References 25 publications

Clinical Characteristics and Current Medical Practice in a Group of Sudanese Patients with Epilepsy: A Cross Sectional Hospital Based-Study

Clinical Characteristics and Current Medical Practice in a Group of Sudanese Patients with Epilepsy: A Cross Sectional Hospital Based-Study

Effect of Chronic Administration of 5-(3-chlorophenyl)-4-Hexyl-2,4 -Dihydro-3H-1,2,4-Triazole-3-Thione (TP-315)—A New Anticonvulsant Drug Candidate—On Living Organisms

Demographics, Clinical Characteristics, and Management Strategies of Epilepsy in Saudi Arabia: A Systematic Review

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