Prevalencia e impacto clínico de las enfermedades reumatológicas autoinmunitarias sistémicas en pacientes con silicosis

Pérez, José Jesús Blanco; Montiel, Victoria Arnalich; Salgado‐Barreira, Ángel; Moure, María Angel Alvarez; Díaz, Adriana Carolina Caldera; González, Rosendo Bugarín; Sanmartín, Abel Pallarés; Villar, Alberto Fernández; Barcala, Francisco Javier González

doi:10.1016/j.arbres.2020.04.012

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Silicosis remains a problem in developing countries, due to lack of preventive measures, but it also remains a major occupational health concern in developed countries, having an important economic and social impact on workers and the healthcare system 1 , 2 . Silica exposure has been associated with diverse pathologies in addition to silicosis, such as the increased risk of tuberculosis and nontuberculous mycobacterial disease, chronic obstructive pulmonary disease, lung cancer, chronic kidney disease and systemic autoimmune rheumatic disease (SARD) 3 , 4 . A diagnosis of silicosis is based on the combination of a history of silica dust exposure and matching radiological findings, along with the exclusion of other entities, such as tuberculosis, fungal infections, sarcoidosis, idiopathic pulmonary fibrosis and other interstitial pulmonary diseases.…”

Section: Introductionmentioning

confidence: 99%

Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers

Blanco-Pérez

Blanco‐Dorado

Rodrı́guez-Garcı́a

et al. 2021

Sci Rep

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Silicosis is a diffuse interstitial lung disease caused by sustained inhalation of silica and silicates. Several cytokines are activated by their inhalation and can mediate the process of pulmonary fibrosis. The identification of biomarkers could allow an early diagnosis before the development of radiological alterations and help monitor the evolution of patients. The objetive of this study was to determine the clinical significance of specific biomarkers, to estimate their association with the development, severity and/or progression of silicosis, and identify determinants of this evolution. We conducted a prospective observational study in patients attending the pulmonology clinic from 2009 to 2018. Serum levels of the following inflammatory mediators were assessed: interleukin-6 (IL-6), interleukin 2 receptor subunit alpha (IL2R) interleukin 1 beta (IL1B), interleukin-8 (IL-8), tumour necrosis factor-alpha (TNF-α), transforming growth factor-beta1 (TGF-β1), alpha-1 antitrypsin (AAT), C-reactive protein (CRP), lactate dehydrogenase (LDH) and ferritin in subjects exposed to silica, with and without silicosis. Association between those inflammatory mediators with lung function measurements and radiological severity of disease and their impact on prognosis were analysed. 337 exposed to silica (278 with silicosis) and 30 subjects in the control group were included. IL-8, α1AT, ferritin, CRP and LDH levels were higher in silicosis than in those exposed to silica without silicosis. IL-8, LDH and AAT levels were associated with progression of silicosis and IL-6, IL-8, LDH, AAT, ferritin, and CRP with vital status. The results of the ROC analysis indicated the potential of IL-8 as a biomarker in the presence of silicosis and for the prediction of mortality.

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Section: Introductionmentioning

confidence: 99%

Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers

Blanco-Pérez

Blanco‐Dorado

Rodrı́guez-Garcı́a

et al. 2021

Sci Rep

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“…La coincidencia en 5 de los 56 casos con una enfermedad reumatológica está en la línea de la reconocida asociación de las neumoconiosis, sobre todo la silicosis, con estas enfermedades, y su peor evolución, con mayor número de visitas al servicio de urgencias y mayor progresión en las silicosis (27) .…”

Section: Discussionunclassified

Enfermedad pulmonar intersticial difusa de posible origen laboral atendida en el Servicio Navarro de Salud. Navarra, España, 2017-2022

García López,

Jové Gómez,

Marin Martinez

et al. 2024

Arch Prev Riesgos Labor

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Introducción: La enfermedad pulmonar intersticial difusa (EPID) describe un amplio grupo de trastornos con inflamación y fibrosis pulmonar. La asbestosis y la silicosis son las principales causas por exposición laboral. El objetivo de este trabajo fue estimar la proporción de casos de posible origen laboral y describir la exposición, situación clínica y laboral. Método: Estudio longitudinal retrospectivo de los casos de EPID, en el período 2017-2022 en el Hospital Universitario de Navarra. Se completó la información con entrevista a los casos de posible origen laboral. Resultados: De un total de 1067 casos de EPID, 56 tuvieron un posible origen laboral, 5,2% (3,9-6,6 IC 95%) 36 (64,3%) correspondieron a asbestosis, 15 (26,8%) a silicosis y 5 (8,9%) a neumoconiosis no especificada. Las actividades más frecuentes en silicosis fueron “corte-tallado de piedra” y para asbestosis ”fabricación productos hierro”. La media de edad de los casos de asbestosis fue superior a los de silicosis (78,2 vs. 67,3 años), así como su afectación clínica. Cinco casos (8,9%) habían sido reconocidos como enfermedad profesional Conclusiones: La implementación de una herramienta informática en historia clínica ha hecho posible estimar la magnitud y valorar la evolución de las EPID laborales atendidas en el servicio nacional de salud. Las actividades económicas reflejan la estructura económica de riesgo de la región. Sin embargo, existe una falta de su reconocimiento como enfermedad profesional y suponen una carga de enfermedad respiratoria evitable.

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From Silicosis to Scleroderma: Erasmus Syndrome

Noboa,

Hernandez-Gonzales,

Lledó

et al. 2023

Open Respiratory Archives

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Prevalencia e impacto clínico de las enfermedades reumatológicas autoinmunitarias sistémicas en pacientes con silicosis

Cited by 4 publications

References 29 publications

Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers

Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers

Enfermedad pulmonar intersticial difusa de posible origen laboral atendida en el Servicio Navarro de Salud. Navarra, España, 2017-2022

From Silicosis to Scleroderma: Erasmus Syndrome

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