Prevalencia del síndrome metabólico (criterios del ATP-III). Estudio de base poblacional en áreas rural y urbana de la provincia de Segovia

Martı́nez-Larrad, Marı́a Teresa; Fernández-Pérez, Cristina; González-Sánchez, José Luis; López, Alicia; Fernández-Álvarez, Josefa; Riviriego, Jesús; Serrano-Rı́os, Manuel

doi:10.1157/13080210

Cited by 79 publications

(24 citation statements)

References 23 publications

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“…This figure is higher than that found in the general population of the United States (34.5%) 17 and Spain (10.2---23%) 18,19 and is also higher than that found in other studies performed with patients with PAD (41---58.5%). 10---13 Nevertheless, in patients with incapacitating claudication and/or critical arterial ischemia, a much higher prevalence of MS has been found Figure 2 Achievement of the therapeutic objectives for LDL-cholesterol levels (<100 mg/dL), blood pressure (<140/90 mmHg) and glycated hemoglobin (in patients with diabetes, <7.0%), according to the presence or absence of metabolic syndrome, after adjusting for risk factors and comorbidity.…”

Section: Discussioncontrasting

confidence: 66%

Metabolic syndrome in patients with peripheral arterial disease

Estirado

Lahoz

Laguna

et al. 2014

Revista Clínica Española (English Edition)

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Section: Discussioncontrasting

confidence: 66%

Metabolic syndrome in patients with peripheral arterial disease

Estirado

Lahoz

Laguna

et al. 2014

Revista Clínica Española (English Edition)

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“…This study comprises 801 non related Caucasian men (n = 433, 54.05%) and women (n = 368, 45.95%) who were recruited by a simple random sampling approach from a cross-sectional population-based epidemiological survey in Spain, aimed at investigating the prevalence of anthropometric and physiological parameters related to obesity and other components of MS [30,31]. Participants with previous diagnosis of type 1 diabetes were excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

WWOX gene is associated with HDL cholesterol and triglyceride levels

Sáez¹,

González‐Pérez²,

Martı́nez-Larrad

et al. 2010

BMC Med Genet

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BackgroundAltered lipid profile, and in particular low HDL and high triglyceride (TG) plasma levels, are within the major determinants of cardiovascular diseases. The identification of quantitative trait loci (QTL) affecting these lipid levels is a relevant issue for predictive purposes. The WWOX gene has been recently associated with HDL levels. This gene is located at chromosome 16q23, a region previously linked to familial combined hyperlipidemia (FCHL) and HDL. Our objective is to perform a genetic association analysis at the WWOX gene region with HDL, TG and TG/HDL ratio.MethodsA quantitative association analysis performed in 801 individuals selected from the Spanish general population.ResultsFor HDL levels, two regions of intron 8 display clustering of positive signals (p < 0.05) but none of them was associated in the haplotypic analysis (0.07 ≤ p ≤ 0.165). For TG levels not only intron 8 but also a 27 kb region spanning from the promoter region to intron 4 are associated in this study. For the TG/HDL genetic association analysis, positive signals are coincident with those of the isolated traits. Interestingly, haplotypic analysis at the 5' region showed that variation in this region modified both HDL and TG levels, especially the latter (p = 0.003).ConclusionsOur results suggest that WWOX is a QTL for both TG and HDL.

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“…This study includes cross-sectional epidemiological analyses in a sample of 768 non-diabetic unrelated Caucasian men (nZ352) and non-pregnant women (nZ416) recruited by a simple random sampling approach from a target population of 63 417 inhabitants in rural and urban areas of the province of Segovia, in Central Spain (Castilla-León), aimed at investigating the prevalence of anthropometric and physiological variables related to IR, obesity, and MS (5). From an original sample of 2992 men and non-pregnant women, 1166 agreed to participate.…”

Section: Populationmentioning

confidence: 99%

Lipid accumulation product: a powerful marker of metabolic syndrome in healthy population

Taverna

Martı́nez-Larrad

Frechtel

et al. 2011

European Journal of Endocrinology

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116

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Objective: The metabolic syndrome (MS) is a cluster of cardiometabolic factors, which predisposes to diabetes and cardiovascular disease (CVD). Early detection of high-risk individuals for MS using accurate measures of insulin resistance (IR) could improve detection and prevention of CVD and diabetes. The aim of this study was to explore the ability of lipid accumulation product (LAP), compared with traditional measures of IR, to identify MS. Design: In total, 768 Spanish adults were recruited. MS was assessed using the revised criteria of National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATP III) and International Diabetes Federation (IDF). Measures of IR such as homeostasis model assessment of IR and LAP, an index of lipid accumulation based on a combination of waist circumference and serum triglycerides, were calculated. Receiver operating characteristic analysis was performed in order to detect the parameter with the best predictive capability for MS. Results: The prevalence of MS-NCEP/ATP III and MS-IDF was 15.1 and 20.5% for men respectively, and 15.4 and 17.5% for women. LAP showed the highest diagnostic accuracy for MS-NCEP/ATP III (area under the curve 0.91 and 0.90 among males and females) and MS-IDF (0.88 for both males and females). This was confirmed by internal validation using 20 000 bootstrap samples. Among males and females, different LAP cut-off values exhibited high sensitivity (78-85%) and specificity (78-85%) for MS-NCEP/ATP III and MS-IDF identification with elevated efficiency (proportion of positives and negatives classified correctly by the testZ78-85%). When the sample was stratified according to decades of life, LAP exhibited a slightly lower performance among women than men, especially for MS-IDF detection. Conclusions: In non-diabetic adults LAP has a strong and reliable diagnostic accuracy for MS-IDF and, especially, MS-NCEP/ATP III among females and, in particular, among males from Spain.

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Prevalencia del síndrome metabólico (criterios del ATP-III). Estudio de base poblacional en áreas rural y urbana de la provincia de Segovia

Cited by 79 publications

References 23 publications

Metabolic syndrome in patients with peripheral arterial disease

Metabolic syndrome in patients with peripheral arterial disease

WWOX gene is associated with HDL cholesterol and triglyceride levels

Lipid accumulation product: a powerful marker of metabolic syndrome in healthy population

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